Product image of Magenlom (Omeprazole) supplied by GNH India

Magenlom

Active Ingredient:
Omeprazole
Origin:
EU

Magenlom (Omeprazole)

Omeprazole, the active ingredient in Magenlom, is a proton pump inhibitor presented as an oral dosage form for oral use. It is employed to reduce gastric acid production in adults with conditions such as gastro‑oesophageal reflux disease, peptic ulcer disease, and other acid‑related disorders.

GNH India supplies Magenlom as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Bennett Pharmaceuticals Sa

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Indications & Clinical Uses

Omeprazole is a proton pump inhibitor used to manage disorders associated with excess gastric acid secretion.

  • Gastro‑oesophageal reflux disease (GERD): reduces acid exposure, relieving heartburn and regurgitation.
  • Peptic ulcer disease: promotes ulcer healing by maintaining a higher gastric pH.
  • Helicobacter pylori eradication regimens: enhances the effectiveness of antibiotic therapy by suppressing acid.
  • Zollinger‑Ellison syndrome: controls hyper‑secretion of gastric acid in this rare endocrine condition.

How It Works

  • Omeprazole irreversibly binds to the H+/K+ ATPase enzyme (gastric proton pump) located on the secretory surface of parietal cells. By inhibiting this final step of acid production, it markedly reduces basal and stimulated gastric acid secretion, leading to an increased gastric pH and facilitating healing of acid‑related mucosal injury.

Side Effects

Adverse reactions to omeprazole can range from mild to severe. Awareness of common and serious events helps clinicians monitor therapy.

Common Side Effects

  • Headache: mild to moderate intensity.
  • Diarrhea: watery stools occurring intermittently.
  • Nausea: occasional feeling of queasiness.
  • Abdominal pain: mild cramping or discomfort.

Serious or Rare Side Effects

  • Severe allergic reactions (anaphylaxis): rapid onset of rash, swelling, and breathing difficulty.
  • Clostridioides difficile infection: persistent watery diarrhea with abdominal pain.
  • Low magnesium levels (hypomagnesemia): muscle cramps, seizures, or cardiac arrhythmia.
  • Bone fracture risk: increased incidence of hip, wrist, or spine fractures with long‑term use.
  • Stevens‑Johnson syndrome: painful skin lesions and mucosal involvement.

Precautions & Warnings

When prescribing omeprazole, consider the following safety measures.

  • Assess renal function: adjust use in patients with severe renal impairment.
  • Monitor magnesium levels: especially during prolonged therapy.
  • Use lowest effective dose: limit duration to the shortest period necessary.
  • Avoid long‑term use unless clearly indicated: reassess need periodically.
  • Store at room temperature: keep in the original container, protect from moisture and direct sunlight.

Avoid Interactions

Omeprazole may alter the pharmacokinetics of several co‑administered medicines.

Major Interactions (Avoid)

  • Clopidogrel: reduced antiplatelet effect, increasing cardiovascular risk.
  • Atazanavir: decreased absorption, leading to sub‑therapeutic antiviral levels.
  • Methotrexate: increased systemic exposure, raising toxicity potential.

Moderate Interactions (Monitor Closely)

  • Warfarin: possible elevation of INR, requiring more frequent coagulation monitoring.
  • Digoxin: may increase serum concentrations, necessitating dose adjustment.

Frequently Asked Questions

Magenlom, containing omeprazole, is used to treat conditions caused by excess stomach acid, including gastro‑oesophageal reflux disease (GERD), peptic ulcer disease, Helicobacter pylori eradication regimens, and Zollinger‑Ellison syndrome. By lowering acid production, it helps relieve symptoms such as heartburn and promotes healing of ulcerated tissue.

Omeprazole works by irreversibly inhibiting the H+/K+ ATPase enzyme, also known as the gastric proton pump, on the surface of parietal cells in the stomach. This blockade stops the final step of acid secretion, leading to a sustained increase in gastric pH and reduction of both basal and stimulated acid output.

The appropriate dose of Magenlom is determined by the prescribing healthcare professional based on the specific indication, patient age, renal function, and treatment duration. Dosage regimens are individualized and should follow the prescriber’s instructions and local clinical guidelines.

Safety data for omeprazole in pregnancy and lactation are limited. It should only be used if the potential benefit justifies any potential risk to the fetus or infant. Healthcare providers should evaluate the risk‑benefit profile for each patient and consider alternative therapies when appropriate.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity of Magenlom. GNH India works with hospitals, pharmacies, and procurement teams worldwide, and will request verification of trade or institutional credentials before providing pricing, availability, shipping details, and any necessary import documentation.

Magenlom (omeprazole) belongs to the proton pump inhibitor (PPI) class, which provides more potent and longer‑lasting acid suppression than H2‑receptor antagonists such as ranitidine. Compared with newer PPIs, omeprazole has a well‑established efficacy and safety profile, making it a common first‑line option for acid‑related disorders.

Magenlom should be stored at room temperature, below 25 °C (77 °F). Keep the product in its original packaging, protect it from moisture and direct sunlight, and ensure the container is tightly closed to maintain stability.

Magenlom is taken orally, usually as a tablet or capsule, with a glass of water. It can be taken with or without food, but for optimal absorption it is often recommended to swallow the dose at least 30 minutes before a meal. Follow the prescriber’s instructions regarding timing and frequency.

Serious risks, though uncommon, include severe allergic reactions such as anaphylaxis, Clostridioides difficile‑associated diarrhea, low magnesium levels leading to muscle cramps or cardiac arrhythmias, increased risk of bone fractures with long‑term use, and rare skin reactions like Stevens‑Johnson syndrome. Patients should seek immediate medical attention if they experience any of these symptoms.

Magenlom should be avoided in patients with known hypersensitivity to omeprazole or any component of the formulation. Caution is advised for individuals with severe liver disease, those taking medications that have major interactions (e.g., clopidogrel, atazanavir, methotrexate), and patients requiring long‑term acid suppression without clear indication.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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