Product image of Magnence (Magnesium) supplied by GNH India

Magnence

Active Ingredient:
Magnesium
Origin:
EU

Magnence (Magnesium)

Magnesium, the active ingredient in Magnence, is a mineral supplement presented as an oral tablet for oral use. It helps correct magnesium deficiency and supports normal neuromuscular function, electrolyte balance, and energy metabolism in adults and children when indicated. The supplement is formulated to provide bioavailable magnesium ions that act as cofactors in numerous enzymatic reactions throughout the body.

GNH India supplies Magnence as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, adhering to EU manufacturing standards and providing consistent product quality for global distribution.

Manufacturer / TM Owner

Kora Corporation Limited

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Indications & Clinical Uses

Magnence is used to address conditions related to low magnesium levels and associated muscular symptoms.

  • Magnesium deficiency: restores normal magnesium concentrations and helps prevent related symptoms.
  • Hypomagnesemia: corrects low serum magnesium and supports cardiovascular and neuromuscular stability.
  • Muscle cramps: reduces frequency and intensity of involuntary muscle contractions by improving electrolyte balance.

How It Works

  • Magnence supplies elemental magnesium that dissociates into Mg2+ ions after oral absorption. These ions serve as essential cofactors for over 300 enzymatic reactions, including those involved in ATP synthesis, protein translation, and ion channel regulation. By replenishing intracellular magnesium stores, the supplement stabilizes neuronal excitability, modulates calcium influx in muscle cells, and contributes to proper electrolyte homeostasis, thereby supporting neuromuscular and metabolic functions.

Side Effects

Oral magnesium supplementation may be associated with a range of adverse reactions, most of which are mild and dose‑related.

Common Side Effects

  • Diarrhea: loose stools occurring with higher intestinal magnesium concentrations.
  • Abdominal cramping: discomfort or pain in the stomach area.
  • Nausea: feeling of queasiness or urge to vomit.
  • Flatulence: increased intestinal gas.
  • Metallic taste: transient alteration in mouth sensation.

Serious or Rare Side Effects

  • Hypermagnesemia: elevated serum magnesium causing muscle weakness, low blood pressure, or cardiac arrhythmia.
  • Severe allergic reaction: rash, itching, swelling, or difficulty breathing.
  • Persistent vomiting: may lead to dehydration and electrolyte imbalance.
  • Renal impairment exacerbation: worsening kidney function in susceptible individuals.

Precautions & Warnings

When considering Magnence, several safety measures and patient‑specific factors should be evaluated.

  • Assess renal function: avoid use or adjust dose in patients with severe kidney disease.
  • Review concomitant medications: magnesium can interact with certain drugs affecting absorption.
  • Monitor serum magnesium: check levels in patients receiving long‑term therapy.
  • Caution in pregnancy: use only if benefits outweigh potential risks, as data are limited.
  • Avoid in known hypersensitivity: discontinue if allergic reactions occur.
  • Store at ambient temperature: keep below 25 °C, retain in original container, protect from moisture and direct sunlight.

Avoid Interactions

Magnence may alter the pharmacokinetics or pharmacodynamics of several medicines, requiring attention to potential interactions.

Major Interactions (Avoid)

  • Bisphosphonates: magnesium reduces oral absorption; separate dosing by at least 2 hours.
  • Tetracycline antibiotics: chelation may markedly decrease antibiotic effectiveness.
  • Fluoroquinolones: concurrent use can impair antibiotic absorption.

Moderate Interactions (Monitor Closely)

  • Calcium channel blockers: additive effect on blood pressure and heart rate.
  • Digoxin: increased serum levels may occur, requiring monitoring.
  • Loop diuretics: may enhance magnesium loss, necessitating dose adjustment.
  • Proton pump inhibitors: may affect magnesium absorption over long term.

Frequently Asked Questions

Magnence is an oral magnesium supplement indicated for the treatment of magnesium deficiency, hypomagnesemia, and for relief of muscle cramps. It helps restore normal magnesium levels, supporting neuromuscular function and electrolyte balance in patients who require supplementation.

Magnesium acts as a cofactor for hundreds of enzymatic reactions, including those involved in ATP production, protein synthesis, and ion channel regulation. By providing Mg2+ ions, it stabilizes nerve and muscle cell excitability, assists calcium handling, and contributes to overall metabolic and cardiovascular health.

The appropriate dose of Magnence is determined by a qualified healthcare professional based on the individual’s age, clinical condition, and laboratory results. Prescribers tailor the regimen to achieve optimal magnesium levels while minimizing the risk of adverse effects.

Safety data for magnesium supplements in pregnancy and lactation are limited. Magnence should only be used during pregnancy or while breastfeeding if the prescriber judges that the potential benefit outweighs any possible risk to the mother or infant.

To order Magnence, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements) and necessary import documentation.

Magnence provides a standardized oral magnesium source that is formulated for reliable bioavailability. Compared with some over‑the‑counter magnesium salts, it offers consistent elemental magnesium content and is manufactured under EU GMP standards, which can result in more predictable absorption and fewer gastrointestinal side effects when taken as directed.

Magnence should be stored at ambient temperature, preferably below 25 °C. Keep the product in its original packaging, protect it from moisture and direct sunlight, and ensure the container is tightly closed to maintain stability throughout its shelf life.

Magnence is taken orally, usually with a full glass of water. It can be taken with or without food, but separating it from certain medications (e.g., bisphosphonates, tetracyclines) by at least two hours helps avoid absorption interference.

The most serious risks include hypermagnesemia, which can cause muscle weakness, hypotension, cardiac arrhythmias, and in severe cases, respiratory depression. Patients with significant renal impairment are particularly vulnerable and should be monitored closely or avoid the product.

Magnence should be avoided in individuals with known hypersensitivity to magnesium or any excipients in the formulation, and in patients with severe renal failure unless closely supervised by a physician. It is also contraindicated when a major drug interaction cannot be managed, such as with certain antibiotics or bisphosphonates taken simultaneously.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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