Product image of Magnesiiumsulfaat Teva (Magnesium Sulfate) supplied by GNH India

Magnesiiumsulfaat Teva

Active Ingredient:
Magnesium Sulfate
Origin:
EU

Magnesiiumsulfaat Teva (Magnesium Sulfate)

Magnesium sulfate, the active ingredient in Magnesiiumsulfaat Teva, is an electrolyte presented as a sterile solution for intra‑articular, intravenous and peri‑articular use. It is employed to correct magnesium deficiency and to manage obstetric, cardiac and respiratory emergencies in appropriate patient populations.

GNH India supplies Magnesiiumsulfaat Teva as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Teva Nederland B.V.

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Indications & Clinical Uses

Magnesium sulfate is employed in several electrolyte‑related and obstetric conditions.

  • Hypomagnesemia: restores normal serum magnesium concentrations.
  • Eclampsia and preeclampsia: prevents seizures in pregnant women with severe hypertension.
  • Torsades de pointes: stabilises cardiac repolarisation to terminate ventricular arrhythmia.
  • Severe asthma exacerbations: provides bronchodilatory support as an adjunct therapy.
  • Intra‑articular injection for joint pain: reduces inflammation and alleviates pain in affected joints.

How It Works

  • Magnesium sulfate dissociates to release Mg2+ ions that serve as essential cofactors for numerous enzymatic reactions, modulate calcium influx, and stabilise neuronal membranes. The ions decrease neuronal excitability, relax smooth muscle, and act as a calcium antagonist, thereby reducing muscle contraction, vasoconstriction and abnormal cardiac depolarisation.

Side Effects

Adverse reactions may range from mild to severe and should be monitored during therapy.

Common Side Effects

  • Flushing or warmth at the injection site
  • Nausea or vomiting
  • Headache
  • Mild hypotension
  • Sweating
  • Transient muscle weakness

Serious or Rare Side Effects

  • Severe hypotension or cardiovascular collapse
  • Respiratory depression
  • Cardiac arrest or severe arrhythmias
  • Anaphylactic or severe allergic reactions
  • Hypermagnesemia with neuromuscular paralysis
  • Tissue necrosis or severe irritation at the injection site

Precautions & Warnings

Magnesium sulfate requires careful assessment of patient risk factors before administration.

  • Renal impairment: monitor serum magnesium and adjust dose.
  • Cardiovascular disease: observe for profound hypotension.
  • Neuromuscular disorders: risk of increased muscle weakness.
  • Pregnancy: use only when clearly indicated and benefits outweigh potential risks.
  • Concomitant medications: review for interactions that may potentiate effects.
  • Store at below 25°C: keep in original container, protect from moisture and direct sunlight.

Avoid Interactions

Magnesium sulfate can modify the activity of several co‑administered drugs.

Major Interactions (Avoid)

  • Calcium channel blockers: additive hypotensive effect.
  • Neuromuscular blocking agents: prolonged paralysis.
  • Digoxin: increased risk of arrhythmia.
  • Loop diuretics: may exacerbate magnesium loss leading to imbalance.
  • Quinidine: heightened risk of cardiac conduction disturbances.

Moderate Interactions (Monitor Closely)

  • Aminoglycoside antibiotics: enhanced neuromuscular blockade.
  • ACE inhibitors: increased chance of hypermagnesemia.
  • NSAIDs: reduced renal clearance of magnesium.
  • β‑agonists: possible attenuation of bronchodilatory benefit.
  • Oral antacids containing magnesium: additive magnesium load.

Frequently Asked Questions

Magnesiiumsulfaat Teva contains magnesium sulfate and is used to correct low magnesium levels, prevent seizures in eclampsia or severe pre‑eclampsia, treat certain life‑threatening cardiac arrhythmias such as torsades de pointes, provide adjunctive therapy in severe asthma attacks, and as an intra‑articular injection to relieve joint pain and inflammation.

Magnesium sulfate releases magnesium ions that act as cofactors for many enzymatic processes, stabilize neuronal membranes, and antagonise calcium entry. This reduces neuronal excitability, relaxes smooth muscle, lowers vascular tone, and helps normalise cardiac electrical activity, which together address the clinical conditions for which the drug is indicated.

The specific dose and infusion rate are determined by the prescribing clinician based on the patient’s condition, weight, renal function and therapeutic goal. Healthcare professionals follow local guidelines and adjust the regimen according to clinical response and laboratory monitoring.

Safety data in pregnancy are limited, but magnesium sulfate is commonly used when the benefit to the mother outweighs potential fetal risk, such as in eclampsia. It is excreted in breast milk in small amounts; breastfeeding decisions should be made in consultation with a healthcare provider.

To place an order, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain if needed) and required import documentation.

Magnesium sulfate is the most widely used intravenous magnesium formulation because of its rapid bioavailability and well‑characterised safety profile. Alternatives such as magnesium chloride or magnesium gluconate are often oral or topical and have different pharmacokinetics, making magnesium sulfate the preferred choice for acute electrolyte correction and obstetric emergencies.

The product should be stored at temperatures below 25 °C, in its original sealed container, protected from moisture and direct sunlight. Before use, inspect the solution for particulate matter or discoloration and discard if any abnormalities are observed.

Magnesiiumsulfaat Teva is supplied as a sterile solution for intravenous, intra‑articular or peri‑articular injection. Administration is performed by a qualified healthcare professional, following aseptic technique and appropriate infusion rates or injection volumes as dictated by the clinical indication.

Serious adverse events include severe hypotension, respiratory depression, cardiac arrest, anaphylaxis, hypermagnesemia leading to neuromuscular paralysis, and local tissue necrosis at the injection site. Prompt recognition and supportive measures are essential if any of these reactions occur.

Magnesium sulfate is contraindicated in patients with known hypersensitivity to magnesium salts, severe renal failure where clearance is markedly reduced, and in those with existing hypermagnesemia. Caution is also advised for individuals with myasthenia gravis or other neuromuscular disorders.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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