Product image of Magnesio Solfato Bioindustria L.I.M. (Magnesium Sulfate Heptahydrate) supplied by GNH India

Magnesio Solfato Bioindustria L.I.M.

Active Ingredient:
Magnesium Sulfate Heptahydrate
Origin:
EU

Magnesio Solfato Bioindustria L.I.M. (Magnesium Sulfate Heptahydrate)

Magnesium sulfate, the active ingredient in Magnesio Solfato Bioindustria L.I.M., is an electrolyte supplement presented as an injection solution for intravenous use. It treats magnesium deficiency‑related conditions such as hypomagnesemia, eclampsia, and cardiac arrhythmias in hospitalized patients.

GNH India supplies Magnesio Solfato Bioindustria L.I.M. as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, transplant centres, oncology centres, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Bioindustria Lim Laboratorio Italiano Medicinali Spa

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Indications & Clinical Uses

Magnesium sulfate is used to replenish magnesium ions in clinical situations involving electrolyte imbalance or magnesium‑dependent cardiac disturbances.

  • Hypomagnesemia: restores serum magnesium levels and prevents neuromuscular irritability.
  • Eclampsia/Pre‑eclampsia: reduces risk of seizures by correcting magnesium deficiency.
  • Torsades de pointes: stabilizes cardiac repolarization and terminates ventricular tachyarrhythmias.
  • Cardiac arrhythmias related to magnesium deficiency: improves conduction and reduces ectopic activity.
  • Magnesium supplementation in critical care: supports metabolic functions and membrane stability in critically ill patients.

How It Works

  • Magnesium sulfate dissociates to release Mg2+ ions that serve as essential cofactors for over 300 enzymatic reactions, including ATP‑dependent processes, and modulate ion channels. The ions stabilize cell membranes, compete with calcium at voltage‑gated channels, and decrease neuronal excitability, thereby correcting hypomagnesemia and exerting anti‑arrhythmic and anticonvulsant effects.

Side Effects

Intravenous magnesium sulfate may be associated with a range of adverse reactions, varying from mild to severe.

Common Side Effects

  • Flushing: transient warmth and redness of the skin.
  • Nausea: mild stomach upset.
  • Hypotension: temporary drop in blood pressure.
  • Injection site pain: discomfort at the infusion site.

Serious or Rare Side Effects

  • Hypermagnesemia: elevated serum magnesium causing neuromuscular weakness and cardiac depression.
  • Respiratory depression: reduced breathing effort, potentially requiring ventilation.
  • Allergic reaction: anaphylaxis with rash, swelling, or bronchospasm.

Precautions & Warnings

When using intravenous magnesium sulfate, clinicians should observe specific safety measures to minimize risks.

  • Renal function: assess kidney function because impaired excretion can lead to accumulation.
  • Cardiac monitoring: continuously monitor ECG and blood pressure during infusion.
  • Concomitant calcium blockers: avoid simultaneous high‑dose calcium channel blockers to prevent additive cardiac effects.
  • Neuromuscular disease: use caution in patients with myasthenia gravis or severe muscle weakness.
  • Pregnancy: consider fetal monitoring when administered to pregnant women.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Magnesium sulfate can interact with several medications, altering their efficacy or safety profile.

Major Interactions (Avoid)

  • Calcium channel blockers: may potentiate hypotensive and cardiac effects.
  • Neuromuscular blocking agents: can enhance muscle relaxation and prolong paralysis.
  • Digoxin: increased risk of arrhythmias due to altered electrolyte balance.

Moderate Interactions (Monitor Closely)

  • Aminoglycoside antibiotics: reduced absorption and efficacy.
  • Loop diuretics: additive risk of electrolyte disturbances.
  • Anticoagulants (warfarin): possible enhancement of anticoagulant effect.

Frequently Asked Questions

Magnesio Solfato Bioindustria L.I.M. is an injectable form of magnesium sulfate used to correct magnesium deficiency. It is indicated for conditions such as hypomagnesemia, eclampsia or pre‑eclampsia, torsades de pointes, and other cardiac arrhythmias that arise from low serum magnesium levels.

Magnesium sulfate provides Mg2+ ions that act as cofactors for many enzymatic reactions, stabilize cell membranes, and antagonize calcium at voltage‑gated channels. This reduces neuronal excitability, supports cardiac electrical stability, and helps reverse the physiological effects of magnesium deficiency.

The dose of magnesium sulfate is individualized by the prescribing clinician based on the patient’s condition, serum magnesium level, and clinical response. Healthcare professionals determine the appropriate concentration, infusion rate, and total amount required for each specific indication.

Magnesium sulfate is commonly used in obstetric care, particularly for preventing seizures in eclampsia and pre‑eclampsia. While it is considered relatively safe when administered under medical supervision, the decision to use it during pregnancy or lactation should be made by a qualified healthcare provider after weighing potential benefits and risks.

To place an order, submit an enquiry on the product page at gnhindia.com indicating the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements), and necessary import documentation.

The primary alternative for magnesium repletion is calcium gluconate, which supplies calcium rather than magnesium and therefore addresses different electrolyte deficits. Magnesium sulfate uniquely restores magnesium levels, offering anti‑arrhythmic and anticonvulsant benefits that calcium salts cannot provide, making it the preferred choice for magnesium‑specific indications.

Magnesio Solfato should be stored at 2‑8 °C in a refrigerator, protected from light, and must not be frozen or shaken. Keep the vial in its original packaging until use to maintain sterility and potency.

The product is supplied as a sterile injection solution for intravenous infusion. It is administered by a qualified healthcare professional, typically through a peripheral or central line, with the infusion rate adjusted according to the patient’s clinical status and monitoring parameters.

The most serious adverse events include hypermagnesemia, which can cause profound neuromuscular weakness, respiratory depression, and cardiac arrest. Rapid infusion may also lead to severe hypotension. Prompt recognition and monitoring are essential to mitigate these risks.

Magnesium sulfate is contraindicated in patients with known hypersensitivity to magnesium salts, severe renal impairment that prevents magnesium excretion, and in individuals with advanced heart block or severe bradycardia unless closely monitored. It should also be used with caution in patients with myasthenia gravis.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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