Product image of Magnesio Solfato Galenica Senese (Magnesium Sulfate Heptahydrate) supplied by GNH India

Magnesio Solfato Galenica Senese

Active Ingredient:
Magnesium Sulfate Heptahydrate
Origin:
EU

Magnesio Solfato Galenica Senese (Magnesium Sulfate Heptahydrate)

Magnesium sulfate, the active ingredient in Magnesio Solfato, is an electrolyte presented as an injectable solution for intramuscular and intravenous use. It is employed to correct magnesium deficiency and to manage conditions such as eclampsia, ventricular arrhythmias, severe asthma exacerbations, and as an adjunct in cardiac arrest.

GNH India supplies Magnesio Solfato as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals worldwide. The company follows stringent quality standards and provides regulatory documentation for across global distribution.

Manufacturer / TM Owner

Industria Farmaceutica Galenica Senese S.R.L..

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Indications & Clinical Uses

  • Magnesium sulfate is used to replenish extracellular magnesium and to treat conditions related to electrolyte imbalance.
  • Magnesium deficiency: restores normal serum magnesium levels.
  • Eclampsia/preeclampsia: prevents and treats seizures in pregnant patients.
  • Ventricular arrhythmias: stabilises cardiac rhythm in torsades de pointes and other life‑threatening arrhythmias.
  • Severe asthma exacerbations: relaxes bronchial smooth muscle to improve airflow.
  • Cardiac arrest adjunct: supports myocardial function and reduces refractory ventricular fibrillation.

How It Works

  • Magnesium sulfate dissociates to release Mg2+ ions, which act as a calcium antagonist and a cofactor for numerous enzymatic reactions. The increased extracellular magnesium stabilises cell membranes, reduces neuromuscular excitability, promotes vasodilation, and modulates cardiac ion channels, thereby correcting magnesium deficiency and mitigating hyper‑excitability in the nervous and cardiovascular systems.

Side Effects

Adverse reactions may occur with magnesium sulfate administration.

Common Side Effects

  • Flushing or feeling of warmth.
  • Sweating.
  • Nausea or vomiting.
  • Mild hypotension.
  • Headache.
  • Local irritation at injection site.

Serious or Rare Side Effects

  • Severe hypotension or cardiovascular collapse.
  • Respiratory depression or arrest.
  • Hypermagnesemia leading to cardiac arrhythmias.
  • Neuromuscular blockade.
  • Anaphylactic reaction.
  • Tissue necrosis if extravasation occurs.

Precautions & Warnings

  • Magnesium sulfate requires careful monitoring in several clinical situations.
  • Renal impairment: monitor serum magnesium and adjust dose.
  • Cardiac disease: use cautiously due to potential hypotension.
  • Neuromuscular disorders: observe for enhanced blockade.
  • Pregnancy: risk unknown; weigh benefits against potential fetal effects.
  • Drug compatibility: avoid mixing with calcium‑containing solutions.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Magnesium sulfate can interact with several medications, requiring attention to avoid adverse outcomes.

Major Interactions (Avoid)

  • Calcium gluconate or calcium chloride: may precipitate and cause embolism.
  • Neuromuscular blocking agents: can potentiate blockade leading to respiratory failure.
  • Aminoglycoside antibiotics: increased risk of neuromuscular weakness.

Moderate Interactions (Monitor Closely)

  • ACE inhibitors or ARBs: may raise serum magnesium levels.
  • Digoxin: risk of toxicity with hypermagnesemia.
  • Quinolone antibiotics: may affect magnesium absorption and reduce efficacy.

Frequently Asked Questions

Magnesio Solfato, containing magnesium sulfate, is prescribed to correct magnesium deficiency, manage eclampsia or preeclampsia in pregnancy, treat life‑threatening ventricular arrhythmias such as torsades de pointes, alleviate severe asthma attacks, and serve as an adjunct in cardiac arrest resuscitation.

Magnesium sulfate releases magnesium ions that act as calcium antagonists, stabilising cell membranes, reducing neuromuscular excitability, promoting vasodilation, and modulating cardiac ion channels. These actions restore normal extracellular magnesium levels and help control abnormal electrical activity in nerves and the heart.

The specific dose of Magnesio Solfato is determined by the prescribing clinician based on the patient’s condition, weight, renal function and response to therapy. Healthcare professionals follow local guidelines and adjust the regimen as needed for safety and efficacy.

Safety data for magnesium sulfate in pregnancy and lactation are limited. It may be used when the potential benefits outweigh any possible risks to the fetus or infant. Clinicians should evaluate each case individually and monitor maternal and neonatal magnesium levels closely.

To request Magnesio Solfato, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain if needed) and import documentation.

Magnesio Solfato is an injectable magnesium sulfate formulation, offering rapid systemic availability compared with oral magnesium salts that have slower absorption. It is preferred in acute settings such as eclampsia, severe asthma, or cardiac arrhythmias where immediate plasma magnesium elevation is required.

The product should be stored at 2‑8 °C, protected from light, and must not be frozen or shaken. Keep the vial in its original packaging until use and inspect for particulate matter or discoloration before administration.

Magnesio Solfato is administered by a healthcare professional via intramuscular or intravenous injection. The route, rate of infusion and concentration are selected according to the clinical indication and patient monitoring requirements.

Serious risks include severe hypotension, respiratory depression, cardiac arrest, hypermagnesemia leading to arrhythmias, and anaphylactic reactions. Prompt monitoring of vital signs, serum magnesium levels and respiratory function is essential, especially in patients with renal impairment or cardiac disease.

Magnesio Solfato is contraindicated in patients with known hypersensitivity to magnesium sulfate, those with severe renal failure where magnesium clearance is impaired, and individuals receiving incompatible calcium‑containing IV solutions. Clinicians should also exercise caution in patients with existing heart block or neuromuscular disorders.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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