Product image of Magnesio Solfato Monico (Magnesium Sulfate Heptahydrate) supplied by GNH India

Magnesio Solfato Monico

Active Ingredient:
Magnesium Sulfate Heptahydrate
Origin:
EU

Magnesio Solfato Monico (Magnesium Sulfate Heptahydrate)

Magnesium sulfate, the active ingredient in Magnesio Solfato Monico, is an electrolyte presented as an injectable solution for intravenous use. It corrects hypomagnesemia and is employed in conditions such as preeclampsia‑related seizures, cardiac arrhythmias, and other magnesium‑deficiency states.
GNH India supplies Magnesio Solfato Monico as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals worldwide.

Manufacturer / TM Owner

Monico S.P.A.

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Indications & Clinical Uses

Magnesium sulfate acts on electrolyte balance and neuromuscular stability, addressing several clinical conditions.

  • Hypomagnesemia: restores serum magnesium levels to prevent neuromuscular and cardiac complications.
  • Prevention of seizures in preeclampsia/eclampsia: provides magnesium to reduce the risk of maternal seizures.
  • Torsades de pointes: stabilises cardiac repolarisation and helps terminate this polymorphic ventricular tachycardia.
  • Cardiac arrhythmias: corrects magnesium deficiency that can precipitate arrhythmic events.
  • Magnesium deficiency: supplies essential magnesium ions for metabolic and enzymatic functions.

How It Works

  • Magnesium sulfate dissociates to release magnesium ions that serve as cofactors for numerous enzymatic reactions, stabilise neuromuscular transmission, and antagonise calcium influx across cell membranes. By increasing extracellular magnesium, it modulates voltage‑gated calcium channels, reduces excitatory neurotransmission, and helps normalise cardiac electrical activity, thereby correcting hypomagnesemia and mitigating related complications.

Side Effects

Adverse reactions may occur with intravenous magnesium administration and should be monitored.

Common Side Effects

  • Flushing or feeling of warmth at the infusion site.
  • Nausea or mild gastrointestinal discomfort.
  • Headache or dizziness.
  • Transient hypotension during rapid infusion.
  • Muscle weakness or fatigue.
  • Local irritation or pain at the injection site.

Serious or Rare Side Effects

  • Severe hypotension leading to shock.
  • Cardiac arrest or profound bradyarrhythmias.
  • Respiratory depression or respiratory arrest.
  • Hypermagnesemia with neuromuscular blockade.
  • Anaphylactic or severe allergic reactions.
  • Persistent arrhythmias despite correction of magnesium levels.

Precautions & Warnings

Magnesium sulfate requires careful monitoring in specific patient populations and clinical situations.

  • Renal impairment: monitor serum magnesium and adjust infusion rate to avoid accumulation.
  • Cardiac disease: use cautiously and observe ECG for conduction changes.
  • Pregnancy: safety category unknown; weigh maternal benefits against potential fetal risks.
  • Concomitant neuromuscular blockers: may potentiate respiratory muscle weakness.
  • Electrolyte imbalance: avoid simultaneous high‑dose calcium or potassium without monitoring.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Magnesium sulfate can interact with several drug classes, influencing efficacy and safety.

Major Interactions (Avoid)

  • Calcium channel blockers: additive effects on cardiac conduction may cause severe bradycardia.
  • Neuromuscular blocking agents: potentiation can lead to prolonged respiratory paralysis.
  • Other magnesium‑containing products: risk of hypermagnesemia and related toxicity.

Moderate Interactions (Monitor Closely)

  • Loop diuretics: increase renal magnesium loss, possibly requiring dose adjustment.
  • ACE inhibitors or ARBs: may alter renal handling of magnesium, necessitating monitoring.
  • Aminoglycoside antibiotics: heightened risk of neuromuscular blockade when combined.

Frequently Asked Questions

Magnesio Solfato Monico contains magnesium sulfate, which is used to treat low blood magnesium levels (hypomagnesemia), prevent seizures in preeclampsia/eclampsia, and manage certain cardiac arrhythmias such as torsades de pointes.

Magnesium sulfate provides magnesium ions that act as essential cofactors for many enzymes, stabilize neuromuscular transmission, and antagonise calcium influx. This helps normalize cardiac electrical activity, relax smooth muscle, and correct electrolyte imbalances.

The appropriate dose of Magnesio Solfato Monico is determined by the prescribing clinician based on the patient’s condition, serum magnesium level, renal function, and other clinical factors. Dosage regimens are not standardized and must follow the prescriber’s order.

The pregnancy safety category for magnesium sulfate is listed as unknown. Use during pregnancy or lactation should only occur when the potential benefits outweigh any possible risks, and it must be prescribed and monitored by a qualified healthcare professional.

To order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain if needed), and import documentation.

Magnesio Solfato Monico is an injectable magnesium sulfate solution, offering rapid intravenous delivery compared with oral magnesium salts that have slower absorption. It is preferred in acute settings such as severe hypomagnesemia, preeclampsia, or life‑threatening arrhythmias where immediate plasma level correction is required.

The product should be stored at 2‑8 °C, kept refrigerated, protected from light, and should not be frozen or shaken. Maintaining the cold‑chain ensures stability and potency of the injectable solution.

Magnesio Solfato Monico is administered intravenously by a qualified healthcare professional. The infusion rate and concentration are set according to the patient’s clinical status and laboratory values, with continuous monitoring for signs of toxicity or adverse reactions.

Serious risks include severe hypotension, cardiac arrest, respiratory depression, hypermagnesemia leading to neuromuscular blockade, and rare anaphylactic reactions. Prompt recognition and supportive measures are essential if any of these events occur.

Patients with known hypersensitivity to magnesium sulfate, severe renal failure without appropriate monitoring, or those receiving contraindicated medications such as high‑dose calcium channel blockers or neuromuscular blockers should not receive this product unless under strict medical supervision.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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