Product image of Magnesio Solfato S.A.L.F (Magnesium Sulfate Heptahydrate) supplied by GNH India

Magnesio Solfato S.A.L.F

Active Ingredient:
Magnesium Sulfate Heptahydrate
Origin:
EU

Magnesio Solfato S.A.L.F (Magnesium Sulfate Heptahydrate)

Magnesium sulfate heptahydrate, the active ingredient in Magnesio Solfato S.A.L.F, is an electrolyte classified as a magnesium replacement therapy presented as a sterile solution for intramuscular and intravenous use. It is employed to correct low magnesium levels and to manage conditions such as eclamptic seizures and certain cardiac arrhythmias.

GNH India supplies Magnesio Solfato S.A.L.F as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, transplant centres, oncology centres, pharmacies and clinics worldwide, with a focus on quality assurance and regulatory compliance across EU and global markets.

Manufacturer / TM Owner

S.A.L.F. Spa Laboratorio Farmacologico

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Indications & Clinical Uses

Magnesium sulfate heptahydrate is used in electrolyte replacement and magnesium deficiency management.

  • Hypomagnesemia: restores serum magnesium concentrations in patients with documented deficiency.
  • Eclamptic seizures: prevents and treats seizures associated with severe pre‑eclampsia in pregnant women.
  • Torsades de pointes: stabilises cardiac repolarisation to terminate this polymorphic ventricular tachycardia.
  • Bowel cleansing: acts as an osmotic laxative to facilitate intestinal evacuation before diagnostic procedures.

How It Works

  • Magnesium sulfate heptahydrate dissociates to release Mg²⁺ ions, which compete with calcium at voltage‑gated channels, reducing neuronal excitability and promoting smooth‑muscle relaxation. The increased extracellular magnesium stabilises cell membranes, induces vasodilation, and modulates cardiac electrophysiology by influencing the Na⁺/K⁺‑ATPase pump and calcium influx, thereby correcting electrolyte imbalances and preventing hyper‑excitability.

Side Effects

Adverse reactions may occur with magnesium sulfate administration.

Common Side Effects

  • Flushing or warmth at the injection site.
  • Nausea or vomiting.
  • Transient hypotension.
  • Headache.
  • Muscle weakness.
  • Dizziness.

Serious or Rare Side Effects

  • Respiratory depression or arrest.
  • Severe hypotension leading to shock.
  • Hypermagnesemia with cardiac conduction disturbances.
  • Anaphylactic or severe allergic reactions.
  • Cardiac arrest.
  • Seizures due to electrolyte imbalance.

Precautions & Warnings

Magnesium sulfate should be used with careful clinical monitoring.

  • Renal impairment: monitor serum magnesium and adjust dose to avoid accumulation.
  • Cardiac disease: observe cardiac rhythm and blood pressure during infusion.
  • Neuromuscular disorders: assess for enhanced muscle relaxation or weakness.
  • Pregnancy: use only when clearly indicated and under obstetric supervision.
  • Drug interactions: review concomitant medications that affect magnesium levels.
  • Store at controlled room temperature: keep in original container, protect from light and moisture.

Avoid Interactions

Magnesium sulfate can interact with several drug classes.

Major Interactions (Avoid)

  • Neuromuscular blocking agents: may potentiate muscle relaxation and respiratory depression.
  • Calcium channel blockers: additive hypotensive effect.
  • Other magnesium‑containing products: risk of hypermagnesemia.

Moderate Interactions (Monitor Closely)

  • Loop diuretics: increase renal magnesium loss, requiring closer monitoring.
  • ACE inhibitors or ARBs: may affect potassium balance and renal function.
  • Tetracycline antibiotics: oral magnesium can reduce antibiotic absorption; separate administration times if both are used.

Frequently Asked Questions

Magnesio Solfato contains magnesium sulfate heptahydrate and is used to treat low blood magnesium levels, prevent seizures in severe pre‑eclampsia, manage certain cardiac arrhythmias such as torsades de pointes, and serve as an osmotic laxative for bowel preparation before procedures.

The compound releases magnesium ions that act as calcium antagonists, stabilising neuronal membranes, reducing excitability, and causing vasodilation. In the heart, magnesium influences ion channels and the Na⁺/K⁺‑ATPase pump, helping to normalise cardiac rhythm and prevent abnormal electrical activity.

The specific dose and infusion rate are determined by the prescribing clinician based on the patient’s condition, weight, renal function and therapeutic goal. Healthcare professionals follow local guidelines and adjust the regimen according to laboratory monitoring and clinical response.

Magnesium sulfate is classified as a pregnancy category that is used only when clearly indicated, such as for eclamptic seizure prevention. It may be administered under obstetric supervision. Limited data are available for breastfeeding, and the decision should be made by a qualified health professional.

To place an order, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements) and necessary import documentation.

Magnesio Solfato provides magnesium as a sterile injectable solution, allowing rapid correction of severe deficiency and precise control in acute settings. Oral magnesium salts are slower acting and may cause gastrointestinal irritation, while other injectable forms may differ in concentration or stabilisers. Choice depends on clinical urgency, route preference and patient tolerance.

The product should be stored at controlled room temperature, typically between 20 °C and 25 °C, in its original packaging. Protect it from direct light, moisture and extreme temperatures. Do not freeze. Inspect the vial for particulate matter or discoloration before use.

Magnesio Solfato is supplied as a sterile solution for intramuscular or intravenous injection. The route, infusion speed and dilution are determined by the prescriber. Intravenous administration is usually performed via a controlled infusion pump, while intramuscular injection follows standard aseptic techniques.

Serious risks include respiratory depression, severe hypotension, cardiac arrest, hypermagnesemia with resultant cardiac conduction abnormalities, and rare anaphylactic reactions. Continuous monitoring of vital signs and serum magnesium levels is essential, especially in patients with renal impairment or cardiac disease.

Magnesio Solfato is contraindicated in patients with known hypersensitivity to magnesium sulfate, severe renal failure where magnesium clearance is markedly reduced, and in those with existing hypermagnesemia. Caution is also advised for individuals with myasthenia gravis or other neuromuscular disorders.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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