Product image of Magnesio Solfato S.A.L.F (Magnesium Sulfate Heptahydrate) supplied by GNH India

Magnesio Solfato S.A.L.F

Active Ingredient:
Magnesium Sulfate Heptahydrate
Origin:
EU

Magnesio Solfato S.A.L.F (Magnesium Sulfate Heptahydrate)

Magnesium sulfate, the active ingredient in Magnesio Solfato S.A.L.F, is an electrolyte presented as a sterile solution for intramuscular and intravenous use. It is employed to correct magnesium deficiency and to manage conditions such as eclampsia, cardiac arrhythmias, severe asthma attacks, and hypocalcemia in hospital settings.

GNH India supplies Magnesio Solfato S.A.L.F as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals worldwide.

Manufacturer / TM Owner

S.A.L.F. Spa Laboratorio Farmacologico

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Indications & Clinical Uses

Magnesio Solfato S.A.L.F is used in clinical situations that require rapid magnesium replacement or specific therapeutic effects related to magnesium deficiency and related disorders.

  • Magnesium deficiency: restores normal serum magnesium levels.
  • Eclampsia and preeclampsia: prevents seizures in pregnant patients.
  • Cardiac arrhythmias (e.g., torsades de pointes): stabilises cardiac electrical activity.
  • Severe asthma exacerbations: provides bronchodilatory support.
  • Hypocalcemia: assists in calcium homeostasis when used with calcium therapy.

How It Works

  • Magnesium sulfate dissociates to release magnesium ions, which serve as essential cofactors for numerous enzymatic reactions, modulate calcium influx at neuromuscular junctions, and promote vasodilation by antagonising calcium‑mediated smooth‑muscle contraction. Intravenous or intramuscular administration rapidly raises extracellular magnesium concentrations, correcting deficiency and exerting anti‑arrhythmic, anticonvulsant, and bronchodilatory effects.

Side Effects

Adverse reactions may occur with magnesium sulfate administration and should be monitored.

Common Side Effects

  • Flushing or warmth at the injection site.
  • Nausea or vomiting.
  • Mild hypotension.
  • Headache.
  • Transient muscle weakness.

Serious or Rare Side Effects

  • Respiratory depression or arrest.
  • Cardiac arrest or severe bradycardia.
  • Hypermagnesemia leading to loss of deep tendon reflexes.
  • Severe hypotension unresponsive to fluids.
  • Allergic reactions such as rash, urticaria, or anaphylaxis.

Precautions & Warnings

Magnesium sulfate should be used with caution in specific clinical contexts.

  • Renal impairment: monitor serum magnesium and adjust dosing.
  • Cardiac disease: observe cardiac rhythm continuously.
  • Neuromuscular disorders: assess for increased muscle weakness.
  • Pregnancy: use only when clearly indicated, as safety data are limited.
  • Drug interactions: review concomitant medications that affect magnesium levels.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Magnesium sulfate may interact with several medications, altering efficacy or safety.

Major Interactions (Avoid)

  • Calcium channel blockers: risk of additive hypotension.
  • Neuromuscular blocking agents: prolonged paralysis.
  • Certain antibiotics (e.g., tetracyclines, quinolones): reduced absorption when given concurrently.

Moderate Interactions (Monitor Closely)

  • Loop diuretics: may increase magnesium loss.
  • ACE inhibitors or ARBs: potential for enhanced hypermagnesemia.
  • Digoxin: monitor serum levels due to possible electrolyte shifts.

Frequently Asked Questions

Magnesio Solfato S.A.L.F provides magnesium sulfate for rapid correction of magnesium deficiency and for therapeutic management of conditions such as eclampsia, certain cardiac arrhythmias, severe asthma attacks, and hypocalcemia in hospital settings.

Magnesium sulfate releases magnesium ions that act as cofactors for many enzymes, stabilize neuromuscular transmission, antagonise calcium‑mediated smooth‑muscle contraction, and produce vasodilatory, anti‑arrhythmic, and bronchodilatory effects when administered intravenously or intramuscularly.

The specific dose and infusion rate are determined by the prescribing clinician based on the patient’s condition, serum magnesium level, renal function, and therapeutic goal. Dosing regimens are individualized and should follow local clinical guidelines.

Safety data for magnesium sulfate in pregnancy are limited, and the product should be used only when clearly indicated. It is excreted in breast milk, so clinicians should weigh potential benefits against risks before prescribing to nursing mothers.

Enquiries can be submitted on the product page at gnhindia.com by specifying the required quantity. GNH India supplies hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain if needed), and import documentation.

Magnesio Solfato S.A.L.F is a sterile magnesium sulfate solution suitable for IV or IM administration, offering rapid bioavailability. Compared with oral magnesium salts, it provides faster correction of severe deficiency and is preferred in acute settings such as eclampsia or life‑threatening arrhythmias.

The product should be stored refrigerated at 2‑8 °C, protected from light, and must not be frozen or shaken. Maintaining the cold chain preserves stability and potency until the point of use.

Magnesio Solfato S.A.L.F is administered by a qualified healthcare professional via intramuscular injection or intravenous infusion, following aseptic technique and appropriate infusion rates as directed by the prescriber.

Serious risks include respiratory depression, cardiac arrest, severe hypotension, hypermagnesemia with loss of deep tendon reflexes, and rare anaphylactic reactions. Continuous monitoring of vital signs and serum magnesium levels is essential during therapy.

Patients with known hypersensitivity to magnesium sulfate, severe renal failure without appropriate monitoring, or those with existing hypermagnesemia should not receive this product unless benefits outweigh the risks and close observation is ensured.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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