Product image of Magnesio Solfato S.A.L.F. (Magnesium Sulfate Heptahydrate) supplied by GNH India

Magnesio Solfato S.A.L.F.

Active Ingredient:
Magnesium Sulfate Heptahydrate
Origin:
EU

Magnesio Solfato S.A.L.F. (Magnesium Sulfate Heptahydrate)

Magnesium sulfate, the active ingredient in Magnesio Solfato S.A.L.F., is a magnesium salt presented as a sterile aqueous solution for intramuscular and intravenous use. It is employed to correct magnesium deficiency and to manage specific obstetric, cardiac and respiratory emergencies in hospitalized patients.

GNH India supplies Magnesio Solfato S.A.L.F. as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals worldwide. The product meets European Union quality standards and is manufactured under GMP conditions, ensuring consistent potency and sterility for clinical use. It is available for bulk purchase and can be integrated into hospital formularies.

Manufacturer / TM Owner

S.A.L.F. Spa Laboratorio Farmacologico

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Indications & Clinical Uses

Magnesium sulfate is used to treat conditions related to magnesium deficiency and acute obstetric or cardiac emergencies.

  • Magnesium deficiency: restores serum magnesium levels and prevents neuromuscular irritability.
  • Preeclampsia/eclampsia: prevents seizures by stabilizing neuronal excitability in pregnant patients.
  • Torsades de pointes: terminates ventricular arrhythmias by correcting electrolyte imbalance.
  • Severe asthma exacerbations: provides bronchodilation through calcium antagonism in refractory cases.

How It Works

  • Magnesium sulfate dissociates to release Mg2+ ions, which act as calcium antagonists and essential cofactors for numerous enzymatic reactions. The ion induces vasodilation, reduces neuromuscular transmission, and stabilizes cardiac myocyte membranes, thereby correcting electrolyte disturbances and mitigating excitatory neuronal activity.

Side Effects

Magnesium sulfate may cause a range of adverse reactions, varying from mild to severe.

Common Side Effects

  • Flushing or warmth at the injection site.
  • Nausea or mild gastrointestinal discomfort.
  • Headache or dizziness.
  • Transient hypotension.

Serious or Rare Side Effects

  • Severe hypotension leading to shock.
  • Respiratory depression or arrest.
  • Hypermagnesemia causing cardiac arrhythmia or cardiac arrest.
  • Anaphylactic reaction with rash, bronchospasm, or angioedema.

Precautions & Warnings

Magnesium sulfate requires careful monitoring in several clinical situations.

  • Renal impairment: monitor serum magnesium and adjust dosing.
  • Cardiac disease: use cautiously in patients with conduction abnormalities.
  • Neuromuscular disorders: avoid rapid bolus in myasthenia gravis.
  • Pregnancy: safety not established; weigh benefits versus risks.
  • Drug interactions: review concomitant calcium channel blockers and neuromuscular blockers.
  • Store below 25°C: keep in original container, protect from moisture and light.

Avoid Interactions

Magnesium sulfate can interact with several drug classes, requiring vigilance.

Major Interactions (Avoid)

  • Calcium channel blockers: additive vasodilatory effect may cause severe hypotension.
  • Neuromuscular blocking agents: enhanced blockade can lead to respiratory failure.
  • Other magnesium-containing products: risk of hypermagnesemia.

Moderate Interactions (Monitor Closely)

  • Loop diuretics: increase renal magnesium loss, may require dose adjustment.
  • Aminoglycoside antibiotics: may heighten neuromuscular weakness.
  • ACE inhibitors or ARBs: can augment hypermagnesemia in patients with renal impairment.

Frequently Asked Questions

Magnesio Solfato S.A.L.F. contains magnesium sulfate and is indicated for correcting magnesium deficiency, preventing seizures in preeclampsia/eclampsia, treating torsades de pointes ventricular arrhythmias, and managing severe asthma exacerbations that do not respond to standard therapy.

Magnesium sulfate releases magnesium ions that act as calcium antagonists, promote vasodilation, reduce neuromuscular excitability, and stabilize cardiac cell membranes. These actions help restore electrolyte balance, prevent abnormal electrical activity in the heart, and relax airway smooth muscle.

The appropriate dose of Magnesio Solfato S.A.L.F. is determined by the prescribing clinician based on the specific indication, patient weight, renal function, and clinical response. Dosing regimens are individualized and should follow local therapeutic guidelines.

Safety data for magnesium sulfate in pregnancy are limited, and the product is classified as pregnancy category unknown. Clinicians must weigh potential benefits against risks, and use it only when clearly indicated. Limited information is available regarding excretion in breast milk, so caution is advised.

To place an order, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain if needed) and necessary import documentation.

Magnesio Solfato S.A.L.F. is a sterile injectable magnesium sulfate solution, offering rapid systemic availability compared with oral magnesium salts that have slower absorption. It is preferred in acute settings such as obstetric emergencies or life‑threatening arrhythmias, whereas oral formulations are used for chronic supplementation.

Store the injectable solution below 25 °C in its original packaging, protecting it from moisture and light. Do not freeze. Inspect the vial for particulate matter or discoloration before use, and follow aseptic techniques during preparation and administration.

The product is supplied as a sterile solution for intramuscular or intravenous injection. Administration route, infusion rate, and dilution are determined by the prescriber according to the clinical indication and patient condition. Monitoring of vital signs and serum magnesium levels is recommended during and after infusion.

Serious risks include severe hypotension, respiratory depression, cardiac arrest due to hypermagnesemia, and anaphylactic reactions. Patients with renal insufficiency, cardiac conduction disorders, or those receiving neuromuscular blockers are at higher risk and require close monitoring.

Magnesio Solfato S.A.L.F. is contraindicated in patients with known hypersensitivity to magnesium sulfate, severe renal failure where magnesium clearance is markedly reduced, and in individuals with existing hypermagnesemia. Caution is also advised for patients with myasthenia gravis or significant cardiac conduction abnormalities.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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