Product image of Magnesium Chlorure Renaudin (Magnesium Chloride Hexahydrate) supplied by GNH India

Magnesium Chlorure Renaudin

Active Ingredient:
Magnesium Chloride Hexahydrate
Origin:
EU

Magnesium Chlorure Renaudin (Magnesium Chloride Hexahydrate)

Magnesium chloride hexahydrate, the active ingredient in Magnesium Chlorure Renaudin, is a magnesium salt presented as an intravenous solution for electrolyte replacement use. It helps restore magnesium levels in patients with deficiency or related cardiac conditions.

GNH India supplies Magnesium Chlorure Renaudin as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals worldwide.

Manufacturer / TM Owner

Laboratoire Renaudin

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Indications & Clinical Uses

Magnesium Chlorure Renaudin provides magnesium ions for patients with conditions that involve low magnesium levels or magnesium‑dependent cardiac instability.

  • Hypomagnesemia: restores serum magnesium to normal ranges in acute deficiency.
  • Torsades de pointes: stabilises cardiac repolarisation and reduces ventricular ectopy.
  • Preeclampsia/eclampsia: corrects magnesium depletion to support seizure prophylaxis and vascular tone.

How It Works

  • Magnesium chloride hexahydrate dissociates after intravenous administration, releasing magnesium ions that act as a physiological cofactor for numerous enzymatic reactions, modulate calcium influx through voltage‑gated channels, and stabilise cell membranes. The increased extracellular magnesium reduces neuronal excitability and influences cardiac electrophysiology, thereby correcting electrolyte imbalances and supporting vascular tone.

Side Effects

Adverse reactions may occur with intravenous magnesium administration.

Common Side Effects

  • Flushing: transient warmth and redness of the skin.
  • Hypotension: mild drop in blood pressure, especially with rapid infusion.
  • Nausea: occasional feeling of queasiness.
  • Headache: mild to moderate intensity.
  • Dizziness: sensation of light‑headedness.
  • Injection site pain: discomfort at the infusion site.

Serious or Rare Side Effects

  • Respiratory depression: reduced breathing effort in high doses.
  • Cardiac arrest: severe bradyarrhythmia or asystole.
  • Hypermagnesemia: excessive serum magnesium leading to neuromuscular blockade.
  • Allergic reaction: rash, urticaria, or anaphylaxis.
  • Severe hypotension: marked circulatory collapse.
  • Muscle weakness: profound loss of strength affecting respiration.

Precautions & Warnings

When using Magnesium Chlorure Renaudin, clinicians should consider several safety measures.

  • Renal impairment: monitor serum magnesium and adjust infusion rate.
  • Cardiac disease: observe ECG for conduction changes.
  • Neuromuscular disorders: watch for increased weakness.
  • Concomitant calcium therapy: avoid simultaneous high‑dose calcium infusions.
  • Pregnancy: use only if benefit outweighs potential risk.
  • Store at ambient temperature: keep below 25 °C, protect from moisture and direct sunlight.

Avoid Interactions

Magnesium chloride can interact with several medicines, requiring attention to dosing and monitoring.

Major Interactions (Avoid)

  • Calcium channel blockers: additive hypotensive effect.
  • Neuromuscular blocking agents: prolonged paralysis.
  • Digoxin: increased risk of toxicity.

Moderate Interactions (Monitor Closely)

  • Loop diuretics: enhanced magnesium loss.
  • Aminoglycoside antibiotics: reduced efficacy.
  • Bisphosphonates: decreased absorption when given orally (not applicable to IV but note systemic effects).

Frequently Asked Questions

Magnesium Chlorure Renaudin is an intravenous magnesium chloride preparation used to correct low magnesium levels (hypomagnesemia), support cardiac rhythm stability in torsades de pointes, and provide magnesium supplementation in conditions such as preeclampsia where magnesium deficiency contributes to clinical complications.

After IV administration, magnesium chloride hexahydrate dissociates into magnesium ions. These ions serve as cofactors for many enzymatic processes, modulate calcium channels, and stabilize neuronal and cardiac cell membranes, thereby helping to normalize electrolyte balance and reduce abnormal electrical activity.

The specific dose and infusion rate are determined by the prescribing clinician based on the patient’s serum magnesium level, renal function, and clinical condition. Dosing is individualized and should follow local guidelines and the prescriber’s judgment.

Safety data are limited. Use during pregnancy or lactation is permitted only when the expected benefit justifies any potential risk to the mother or infant. Clinicians should evaluate each case and follow applicable obstetric guidelines.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain if needed), and import documentation.

Magnesium Chlorure Renaudin delivers magnesium as chloride, which is highly soluble and provides rapid elevation of serum magnesium. Compared with magnesium sulfate, chloride offers a slightly different electrolyte profile and may be preferred when chloride supplementation is also desired. Choice depends on clinical context and physician preference.

The product should be stored at ambient temperature, below 25 °C, in its original container. Protect it from moisture, direct sunlight, and extreme temperature fluctuations. Do not freeze. Inspect the solution for particulate matter before administration.

Magnesium Chlorure Renaudin is given intravenously. The infusion rate is set by the healthcare professional, typically using a calibrated infusion pump, and the solution is administered through a peripheral or central venous line under aseptic conditions.

Serious risks include hypermagnesemia, which can cause respiratory depression, cardiac arrest, and profound hypotension. Rapid infusion may also trigger severe hypotension or allergic reactions. Continuous monitoring of vital signs and serum magnesium levels is essential during therapy.

Patients with severe renal failure, uncontrolled heart block, or known hypersensitivity to magnesium chloride should not receive this product unless the benefits clearly outweigh the risks. Clinicians must assess each individual’s contraindications before initiating therapy.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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