Product image of Magnesium Demo (Magnesium Sulfate Heptahydrate) supplied by GNH India

Magnesium Demo

Active Ingredient:
Magnesium Sulfate Heptahydrate
Origin:
EU

Magnesium Demo (Magnesium Sulfate Heptahydrate)

Magnesium sulfate, the active ingredient in Magnesium Demo, is an electrolyte supplement presented as an injectable solution for intravenous use. It is employed to correct magnesium deficiency and to manage conditions such as eclampsia, pre‑eclampsia, torsades de pointes, asthma exacerbations, and cardiac arrhythmias in hospitalized patients and other acute‑care settings.

GNH India supplies Magnesium Demo as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals worldwide.

Manufacturer / TM Owner

Demo Abee

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Indications & Clinical Uses

Magnesium sulfate is used in the management of electrolyte disturbances and related cardiovascular or obstetric conditions.

  • Magnesium deficiency: restores normal magnesium levels and supports neuromuscular function.
  • Eclampsia: prevents seizures by stabilising neuronal excitability.
  • Pre‑eclampsia: reduces risk of progression to eclamptic seizures.
  • Torsades de pointes: shortens QT interval and terminates ventricular tachyarrhythmia.
  • Asthma exacerbations: relaxes bronchial smooth muscle to improve airflow.
  • Cardiac arrhythmias: stabilises cardiac electrical activity and prevents ectopic beats.

How It Works

  • Magnesium sulfate dissociates to release Mg2+ ions that serve as essential cofactors for over 300 enzymatic reactions, including ATP‑dependent processes. The ions modulate calcium influx, stabilize cell membranes, and act as natural calcium antagonists, leading to vasodilation, bronchodilation, and suppression of abnormal neuronal firing. By correcting intracellular magnesium deficits, the drug supports normal neuromuscular transmission, cardiac conduction, and vascular tone.

Side Effects

Adverse reactions may range from mild to severe and should be monitored during therapy.

Common Side Effects

  • Flushing or feeling of warmth.
  • Nausea or vomiting.
  • Headache.
  • Hypotension.
  • Sweating.
  • Dizziness.

Serious or Rare Side Effects

  • Respiratory depression.
  • Cardiac arrest or severe bradycardia.
  • Hypermagnesemia with neuromuscular weakness.
  • Anaphylactic reaction.
  • Severe hypotension leading to shock.
  • Arrhythmias such as ventricular tachycardia.

Precautions & Warnings

Careful assessment and monitoring are required before and during administration.

  • Renal impairment: monitor serum magnesium and adjust infusion rate.
  • Cardiac disease: observe ECG and blood pressure continuously.
  • Pregnancy: use only when clearly indicated and benefits outweigh risks.
  • Concomitant neuromuscular blockers: monitor for prolonged paralysis.
  • Electrolyte imbalance: correct potassium and calcium levels prior to infusion.
  • Store at ambient temperature: keep in original container, protect from light and moisture.

Avoid Interactions

Magnesium sulfate can interact with several medicines, altering efficacy or safety.

Major Interactions (Avoid)

  • Calcium channel blockers: additive hypotensive effect.
  • Neuromuscular blocking agents: prolonged muscle paralysis.
  • Loop diuretics: increased renal magnesium loss.
  • Potassium‑sparing diuretics: heightened risk of hypermagnesemia.

Moderate Interactions (Monitor Closely)

  • Aminoglycoside antibiotics: enhanced neuromuscular blockade.
  • ACE inhibitors: possible additive blood pressure reduction.
  • Beta‑agonists: may affect magnesium homeostasis.

Frequently Asked Questions

Magnesium Demo contains magnesium sulfate and is used to correct magnesium deficiency, manage eclampsia and pre‑eclampsia, treat certain cardiac arrhythmias such as torsades de pointes, and aid in severe asthma exacerbations. It is administered intravenously in hospital settings under medical supervision.

Magnesium sulfate releases magnesium ions that act as cofactors for many enzymatic reactions, stabilize cell membranes, and antagonise calcium entry. This results in vasodilation, bronchodilation, and modulation of neuronal excitability, helping to prevent seizures, normalize cardiac rhythm, and improve muscle function.

The appropriate dose of Magnesium Demo is determined by the prescribing clinician based on the patient’s condition, weight, renal function and serum magnesium level. Dosage regimens vary widely, so the prescriber sets the exact infusion rate and total amount.

Magnesium sulfate is classified as a pregnancy category that should be used only when clearly indicated. It may be administered to pregnant women for eclampsia under strict medical supervision. Limited data are available for breastfeeding, and the decision should be made by the treating physician.

To place an order, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain if needed) and required import documentation.

Magnesium Demo is an injectable magnesium sulfate formulation, offering rapid correction of severe deficiency and immediate therapeutic effect, unlike oral magnesium salts which have slower absorption. Compared with other IV magnesium products, it provides a well‑established safety profile and is widely used for obstetric and cardiac emergencies.

Magnesium Demo should be stored at ambient temperature, preferably below 25 °C, in its original packaging to protect from moisture and light. Do not freeze the product. Before use, inspect the solution for particulate matter or discoloration and discard if any abnormalities are observed.

Magnesium Demo is given by intravenous infusion. The rate and duration are set by the prescriber, often starting with a loading dose followed by a maintenance infusion, while monitoring vital signs, serum magnesium levels and cardiac rhythm throughout the procedure.

The most serious risks include severe hypotension, respiratory depression, cardiac arrest, hypermagnesemia leading to neuromuscular weakness, and rare anaphylactic reactions. Continuous monitoring of blood pressure, respiratory status and serum magnesium is essential to detect and manage these complications promptly.

Magnesium Demo is contraindicated in patients with known hypersensitivity to magnesium sulfate, severe renal failure where magnesium clearance is markedly reduced, and in those with existing hypermagnesemia. Caution is also advised for patients with heart block, myasthenia gravis or concurrent use of potent neuromuscular blockers.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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