Product image of Magnesium Diasporal 2mmol (Magnesium Sulfate Heptahydrate) supplied by GNH India

Magnesium Diasporal 2mmol

Active Ingredient:
Magnesium Sulfate Heptahydrate
Origin:
EU

Magnesium Diasporal 2mmol (Magnesium Sulfate Heptahydrate)

Magnesium sulfate heptahydrate, the active ingredient in Magnesium Diasporal 2mmol, is a magnesium sulfate presented as a 2 mmol injectable solution for intramuscular and intravenous use. It is employed to correct magnesium deficiency and to manage conditions such as eclampsia, cardiac arrhythmias, and severe asthma exacerbations.

GNH India supplies Magnesium Diasporal 2mmol as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals worldwide.

Manufacturer / TM Owner

Protina Pharmazeutische Gesellschaft Mbh

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Indications & Clinical Uses

Magnesium Diasporal 2mmol is used to address electrolyte disturbances and related clinical situations where magnesium supplementation is required.

  • Magnesium deficiency: restores normal serum magnesium concentrations.
  • Eclampsia and pre‑eclampsia: prevents seizures by stabilising neuronal excitability.
  • Torsades de pointes: shortens QT interval and reduces ventricular arrhythmia risk.
  • Severe asthma exacerbations: relaxes bronchial smooth muscle to improve airflow.
  • Cardiac arrhythmias: supports myocardial electrical stability and conduction.

How It Works

  • Magnesium sulfate heptahydrate dissociates to release Mg²⁺ ions that serve as essential cofactors for numerous enzymatic reactions, stabilize cell membranes, and antagonize calcium‑mediated excitability. By competing with calcium at voltage‑gated channels, magnesium reduces neuronal firing, smooth‑muscle contraction, and cardiac depolarisation, thereby correcting electrolyte deficits and mitigating hyperexcitability.

Side Effects

Adverse reactions may occur with magnesium sulfate administration.

Common Side Effects

  • Flushing or warmth at the injection site
  • Nausea or vomiting
  • Headache or dizziness
  • Mild hypotension
  • Sweating or feeling of warmth
  • Transient facial tingling

Serious or Rare Side Effects

  • Severe hypotension or cardiovascular collapse
  • Respiratory depression or apnea
  • Hypermagnesemia leading to cardiac arrest
  • Neuromuscular blockade causing muscle weakness
  • Arrhythmias such as bradycardia
  • Allergic reactions including rash or anaphylaxis

Precautions & Warnings

Magnesium Diasporal 2mmol requires careful clinical monitoring.

  • Renal impairment: monitor serum magnesium and adjust dose.
  • Cardiac disease: use cautiously in patients with conduction abnormalities.
  • Neuromuscular disorders: assess risk of prolonged blockade.
  • Pregnancy: limited safety data; evaluate risk‑benefit before use.
  • Concomitant medications: review for potential interactions.
  • Store at ambient temperature: keep in original container, protect from light and moisture.

Avoid Interactions

Magnesium sulfate can interact with several drug classes.

Major Interactions (Avoid)

  • Calcium channel blockers: additive hypotensive effect.
  • Neuromuscular blocking agents: prolonged muscle relaxation.
  • Other magnesium‑containing products: risk of hypermagnesemia.

Moderate Interactions (Monitor Closely)

  • Loop diuretics: increased renal magnesium loss.
  • ACE inhibitors or ARBs: may alter renal magnesium handling.
  • Aminoglycoside or tetracycline antibiotics: reduced absorption when given concurrently.

Frequently Asked Questions

Magnesium Diasporal 2mmol is prescribed to treat magnesium deficiency, prevent seizures in eclampsia or pre‑eclampsia, manage torsades de pointes, assist in severe asthma exacerbations, and stabilize cardiac rhythm in various arrhythmias. It provides rapid magnesium repletion via intramuscular or intravenous administration.

The compound releases magnesium ions that act as cofactors for many enzymes, stabilize cell membranes, and antagonize calcium‑mediated excitability. This reduces neuronal firing, relaxes smooth muscle, and supports normal cardiac electrical activity, thereby correcting electrolyte imbalance and mitigating hyperexcitability.

The specific dose and infusion rate are determined by the prescribing clinician based on the patient’s clinical condition, serum magnesium level, renal function, and therapeutic goal. Healthcare professionals adjust the regimen to achieve safe and effective magnesium concentrations.

Safety data for magnesium sulfate in pregnancy are limited, and the product is not classified in a specific pregnancy category. Clinicians should weigh potential benefits against risks and consider alternative therapies when appropriate. Breastfeeding considerations should also be discussed with a healthcare provider.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements), and necessary import documentation.

Magnesium Diasporal 2mmol delivers magnesium as sulfate heptahydrate, offering rapid bioavailability via injection. Compared with oral magnesium salts, it achieves higher serum levels more quickly, which is essential in acute settings such as eclampsia or severe arrhythmias. Its electrolyte profile differs from magnesium chloride or gluconate formulations, which may be chosen for different tolerability or dosing considerations.

The product should be stored at ambient temperature, below 25 °C, in its original packaging to protect from moisture and light. Do not freeze. Before administration, inspect the solution for particulate matter or discoloration and use aseptic technique as recommended for injectable medicines.

Magnesium Diasporal 2mmol is administered by a qualified healthcare professional via intramuscular injection or intravenous infusion. The route, infusion rate, and total dose are selected based on the indication, patient weight, and clinical response, with continuous monitoring of vital signs and serum magnesium levels.

Serious risks include severe hypotension, respiratory depression, hypermagnesemia leading to cardiac arrest, and profound neuromuscular blockade. Patients with renal insufficiency or existing cardiac conduction abnormalities are particularly vulnerable, and close monitoring is essential during and after administration.

Contraindications include patients with known hypersensitivity to magnesium sulfate, severe renal failure where magnesium clearance is markedly reduced, and individuals with existing hypermagnesemia. Caution is also advised for patients with myasthenia gravis or other neuromuscular disorders that could be exacerbated by magnesium.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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