Magnesium Diasporal Protina Pharmazeutische Gesellschaft Mbh (Magnesium Citrate)

Magnesium citrate acts as a mineral supplement that restores magnesium balance in the body and supports neuromuscular function.

• Magnesium deficiency: replenishes low magnesium stores and normalises serum levels.
• Hypomagnesemia: corrects clinically significant low magnesium concentrations.
• Muscle cramps: helps reduce the frequency and intensity of involuntary muscle contractions.
• Constipation: draws water into the intestinal lumen to promote softer stools and regular bowel movements.

• After oral ingestion, magnesium citrate dissociates to release magnesium ions, which serve as essential cofactors for numerous enzymatic reactions, including ATP synthesis, protein production and ion transport. The increased extracellular magnesium supports neuromuscular transmission, stabilises cell membranes and contributes to electrolyte homeostasis, while the citrate component can exert a mild osmotic effect in the gastrointestinal tract.

Magnesium citrate is generally well tolerated, but some users may experience adverse reactions.

Common Side Effects

• Diarrhoea: loose stools due to osmotic activity in the gut.
• Abdominal cramping: mild to moderate discomfort after dosing.
• Nausea: transient feeling of queasiness.
• Flatulence: increased intestinal gas.

Serious or Rare Side Effects

• Hypermagnesemia: elevated serum magnesium causing weakness, hypotension or cardiac arrhythmia.
• Severe allergic reaction: rash, itching, swelling or anaphylaxis.
• Electrolyte imbalance: significant shifts in calcium or potassium levels.

When using magnesium citrate, consider the following safety measures.

• Renal impairment: monitor magnesium levels and adjust dose if needed.
• Cardiac disease: use with caution in patients with conduction disorders.
• Concomitant medications: review all drugs for potential interactions.
• Pregnancy and breastfeeding: consult a healthcare professional before use.
• Store at room temperature: keep in the original container, protect from moisture and direct sunlight.

Magnesium citrate can influence the absorption or effects of other medicines.

Major Interactions (Avoid)

• Antacids containing aluminum or calcium: may significantly reduce magnesium absorption.
• Intravenous magnesium preparations: concurrent use can lead to excessive magnesium levels.

Moderate Interactions (Monitor Closely)

• Loop diuretics (e.g., furosemide): increase urinary magnesium loss, potentially requiring dose adjustment.
• Certain antibiotics (e.g., tetracyclines, fluoroquinolones): may have reduced efficacy when taken together.
• Bisphosphonates: spacing of at least 2 hours recommended to avoid absorption interference.