Product image of Magnesium Sulfate Aurum Pharmaceuticals (Magnesium Sulfate Heptahydrate) supplied by GNH India

Magnesium Sulfate Aurum Pharmaceuticals

Active Ingredient:
Magnesium Sulfate Heptahydrate
Origin:
EU

Magnesium Sulfate Aurum Pharmaceuticals (Magnesium Sulfate Heptahydrate)

Magnesium sulfate, the active ingredient in Magnesium Sulfate Aurum Pharmaceuticals, is an electrolyte presented as an injectable solution for intramuscular and intravenous use. It is employed to correct severe magnesium deficiency and to manage obstetric and cardiac emergencies where rapid magnesium repletion is required.
GNH India supplies Magnesium Sulfate Aurum Pharmaceuticals as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals worldwide.

Manufacturer / TM Owner

Aurum Pharmaceuticals Ltd

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Indications & Clinical Uses

Magnesium sulfate is used in clinical situations that involve electrolyte imbalance or neuromuscular hyperexcitability.

  • Severe hypomagnesemia: restores serum magnesium levels to prevent cardiac arrhythmias and neuromuscular irritability.
  • Eclampsia and pre‑eclampsia: reduces seizure risk by stabilising neuronal excitability in pregnant patients.
  • Torsades de pointes: shortens QT interval and helps terminate this ventricular tachyarrhythmia.
  • Preterm labor (tocolysis): relaxes uterine smooth muscle to delay premature contractions.

How It Works

  • Magnesium sulfate dissociates to release Mg2+ ions that act as calcium antagonists, stabilising cell membranes, decreasing acetylcholine release at neuromuscular junctions, and reducing neuronal excitability. The increased extracellular magnesium competes with calcium for voltage‑gated channels, leading to vasodilation, decreased myocardial excitability, and smooth‑muscle relaxation, thereby correcting hypomagnesemia and providing therapeutic effects in obstetric and cardiac emergencies.

Side Effects

Adverse reactions may vary with dose and route of administration.

Common Side Effects

  • Flushing or feeling of warmth
  • Nausea or vomiting
  • Headache
  • Dizziness or light‑headedness

Serious or Rare Side Effects

  • Hypotension or cardiovascular collapse
  • Respiratory depression, especially with rapid IV administration
  • Severe allergic reaction (anaphylaxis)
  • Hypermagnesemia leading to muscle weakness, arrhythmias, or cardiac arrest

Precautions & Warnings

Magnesium sulfate requires careful monitoring in several clinical situations.

  • Renal impairment: monitor serum magnesium and adjust dose to avoid accumulation.
  • Cardiac disease: use cautiously in patients with conduction abnormalities or heart block.
  • Pregnancy: assess benefit‑risk ratio, especially in the third trimester.
  • Concomitant medications: review for agents that may potentiate neuromuscular blockade or affect magnesium levels.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Magnesium sulfate can alter the activity of several drugs; interactions are classified by clinical significance.

Major Interactions (Avoid)

  • Neuromuscular blocking agents: potentiation of muscle relaxation.
  • Calcium channel blockers: additive hypotensive effect.
  • Aminoglycoside antibiotics: increased risk of neurotoxicity.

Moderate Interactions (Monitor Closely)

  • Loop diuretics: may increase renal magnesium loss.
  • ACE inhibitors or ARBs: can raise serum magnesium levels.
  • Digoxin: magnesium levels influence digoxin toxicity risk.

Frequently Asked Questions

Magnesium Sulfate Aurum Pharmaceuticals is indicated for the rapid correction of severe hypomagnesemia, prevention and treatment of seizures in eclampsia and pre‑eclampsia, management of torsades de pointes ventricular tachycardia, and as a tocolytic to delay preterm labor. It is administered by intramuscular or intravenous injection under medical supervision.

Magnesium sulfate supplies Mg2+ ions that act as calcium antagonists, stabilising neuronal membranes, reducing acetylcholine release at neuromuscular junctions, and relaxing smooth muscle. These actions lower excitability, help control seizures, correct cardiac rhythm disturbances, and inhibit uterine contractions, thereby addressing the underlying pathophysiology of its approved uses.

The specific dose and infusion rate of magnesium sulfate are determined by the prescribing clinician based on the indication, patient weight, renal function, and clinical response. Healthcare professionals calculate the appropriate regimen and monitor serum magnesium levels to ensure safe and effective therapy.

Magnesium sulfate is classified as pregnancy category unknown, but it is commonly used in obstetric care for eclampsia, pre‑eclampsia, and preterm labor when the benefits outweigh potential risks. Limited data exist on excretion into breast milk; clinicians should evaluate the risk‑benefit profile for nursing mothers on a case‑by‑case basis.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain logistics if needed), and necessary import documentation.

Magnesium sulfate is the preferred source of magnesium for rapid intravenous or intramuscular repletion, whereas other electrolytes such as potassium chloride or calcium gluconate address different deficiencies. Compared with oral magnesium salts, the injectable form achieves faster serum level correction and is essential in acute settings like eclampsia or severe arrhythmias.

Magnesium Sulfate Aurum Pharmaceuticals should be stored at 2‑8 °C, protected from light, and kept in its original packaging. Do not freeze or shake the vial. Before use, inspect for particulate matter or discoloration and discard if the solution appears compromised.

The product is supplied as a sterile injectable solution for intramuscular or intravenous administration. Intravenous infusion should be performed slowly, often using a controlled infusion pump, while intramuscular injection is given into a large muscle group. Administration technique follows institutional protocols and the prescriber's instructions.

Serious risks include hypermagnesemia, which can cause muscle weakness, respiratory depression, hypotension, cardiac arrhythmias, and cardiac arrest. Rapid intravenous administration may also precipitate sudden drops in blood pressure. Prompt monitoring of serum magnesium, blood pressure, and respiratory status is essential to mitigate these hazards.

Magnesium sulfate is contraindicated in patients with known hypersensitivity to magnesium salts, severe renal failure where clearance is markedly reduced, and in individuals with existing profound hypotension or heart block unless closely monitored. Clinicians must assess each patient’s medical history before initiating therapy.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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