Product image of Magnija Sulfāts (Magnesium Sulfate Heptahydrate) supplied by GNH India

Magnija Sulfāts

Active Ingredient:
Magnesium Sulfate Heptahydrate
Origin:
EU

Magnija Sulfāts (Magnesium Sulfate Heptahydrate)

Magnesium sulfate, the active ingredient in Magnija Sulfāts, is a magnesium compound presented as a sterile injectable solution for intramuscular and intravenous use. It replenishes magnesium ions, supporting enzymatic reactions, neuromuscular transmission and cardiac electrophysiology, and is employed in the management of magnesium deficiency and related acute clinical conditions. The product conforms to EU pharmacopeial standards and is indicated for emergency obstetric care, cardiac arrhythmias, severe asthma and other electrolyte disturbances.

GNH India supplies Magnija Sulfāts as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals worldwide.

Manufacturer / TM Owner

Kalceks

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Indications & Clinical Uses

Magnija Sulfāts acts on electrolyte balance and neuromuscular function, making it useful in several acute medical situations.

  • Magnesium deficiency: restores normal serum magnesium levels and prevents related neuromuscular symptoms.
  • Eclampsia and severe preeclampsia: prevents seizures by stabilising neuronal excitability.
  • Torsades de pointes and other ventricular arrhythmias: shortens QT interval and reduces arrhythmic risk.
  • Severe asthma exacerbations: relaxes bronchial smooth muscle to improve airflow.
  • Acute myocardial infarction (adjunct therapy): supports cardiac electrophysiology during reperfusion.

How It Works

  • Magnesium sulfate dissociates to release Mg2+ ions that serve as essential cofactors for over 300 enzymatic reactions, modulate calcium influx, and stabilize cell membranes. In the cardiovascular system, magnesium antagonises calcium‑mediated depolarisation, thereby normalising cardiac conduction and reducing excitability. In the nervous system, it blocks NMDA receptors and dampens neuronal firing, which helps prevent seizures and relaxes bronchial smooth muscle.

Side Effects

Adverse reactions may occur with intravenous or intramuscular administration.

Common Side Effects

  • Flushing or warmth at the injection site
  • Sweating or feeling of heat
  • Nausea or mild gastrointestinal discomfort
  • Headache or dizziness
  • Transient hypotension
  • Muscle weakness or fatigue

Serious or Rare Side Effects

  • Severe hypotension or cardiovascular collapse
  • Respiratory depression or apnea
  • Cardiac arrest or severe arrhythmias
  • Hypermagnesemia with neuromuscular blockade
  • Anaphylactic or severe allergic reaction
  • Tissue necrosis or ulceration at injection site

Precautions & Warnings

Use of Magnija Sulfāts requires careful clinical assessment and monitoring.

  • Renal impairment: monitor serum magnesium and adjust dosage to avoid accumulation.
  • Cardiac disease: observe ECG and blood pressure continuously during administration.
  • Pregnancy: safety category unknown; weigh potential benefits against risks before use.
  • Concomitant neuromuscular blockers: increased risk of prolonged paralysis; monitor neuromuscular function.
  • Administration: verify correct concentration and route (IV/IM) before injection.
  • Store below 25°C: keep in original container, protect from moisture and light.

Avoid Interactions

Magnesium sulfate can affect the activity of several other medicines.

Major Interactions (Avoid)

  • Calcium‑containing solutions: may precipitate magnesium sulfate, reducing efficacy.
  • Neuromuscular blocking agents: potentiation can lead to prolonged paralysis.
  • High‑dose aminoglycosides: increased risk of neuromuscular blockade.

Moderate Interactions (Monitor Closely)

  • Loop diuretics: enhance renal magnesium loss; monitor serum levels.
  • ACE inhibitors or ARBs: additive effects on electrolyte balance; watch potassium.
  • Antacids containing aluminum or magnesium: may interfere with absorption (relevant for oral forms).

Frequently Asked Questions

Magnija Sulfāts is used to treat magnesium deficiency, prevent seizures in eclampsia and severe preeclampsia, manage ventricular arrhythmias such as torsades de pointes, aid severe asthma exacerbations, and serve as an adjunct in acute myocardial infarction to stabilise cardiac electrophysiology.

Magnesium sulfate releases magnesium ions that act as cofactors for many enzymes, regulate calcium channels, stabilise cell membranes, and modulate neuronal excitability. These actions help normalise cardiac conduction, relax smooth muscle in the airways, and prevent seizure activity.

The dosage of Magnija Sulfāts is determined by the prescribing clinician based on the specific indication, patient weight, renal function and clinical response. Only a qualified health professional should set the dose and administration schedule.

The pregnancy safety category for magnesium sulfate is listed as unknown. Use during pregnancy or while breastfeeding should only occur when the potential benefits outweigh any possible risks, and under close medical supervision.

To order, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain if needed) and import documentation.

Magnija Sulfāts is a sterile injectable form of magnesium sulfate, offering rapid systemic availability compared with oral magnesium salts, which are slower and may cause gastrointestinal side effects. It is preferred in emergency settings such as eclampsia or severe arrhythmias where immediate plasma magnesium elevation is required.

Magnija Sulfāts should be stored below 25 °C in its original packaging, protected from moisture and direct light. Do not freeze the product, and keep the vial tightly sealed until use to maintain sterility and potency.

The product is administered by a qualified health professional either intravenously or intramuscularly, using aseptic technique. The exact route, infusion rate or injection volume is dictated by the clinical indication and the prescriber’s orders.

Serious risks include severe hypotension, respiratory depression, cardiac arrest, hypermagnesemia leading to neuromuscular blockade, and rare anaphylactic reactions. Prompt monitoring of vital signs and serum magnesium levels is essential during and after administration.

Patients with known hypersensitivity to magnesium sulfate, severe renal failure without appropriate monitoring, or those receiving interacting neuromuscular blocking agents without supervision should avoid Magnija Sulfāts. Clinical judgment is required for all other contraindications.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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