Product image of Magnesium Sulfate Heptahydrate Kalceks (Magnesium Sulfate Heptahydrate) supplied by GNH India

Magnesium Sulfate Heptahydrate Kalceks

Active Ingredient:
Magnesium Sulfate Heptahydrate
Origin:
EU

Magnesium Sulfate Heptahydrate Kalceks (Magnesium Sulfate Heptahydrate)

Magnesium sulfate heptahydrate, the active ingredient in Magnesium Sulfate Heptahydrate Kalceks, is a mineral salt presented as a sterile injectable solution for intramuscular and intravenous use. It is employed to prevent and treat eclampsia and severe preeclampsia, to correct magnesium deficiency, and to manage torsades de pointes cardiac arrhythmia.

GNH India supplies Magnesium Sulfate Heptahydrate Kalceks as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals worldwide.

Manufacturer / TM Owner

Kalceks

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Indications & Clinical Uses

Magnesium sulfate heptahydrate acts on electrolyte balance and neuromuscular transmission, making it useful in several clinical settings.

  • Eclampsia and severe preeclampsia: prevents seizures and stabilises maternal blood pressure in pregnant women.
  • Magnesium deficiency: restores normal serum magnesium levels and supports neuromuscular function.
  • Torsades de pointes: terminates ventricular tachyarrhythmia by stabilising cardiac electrical activity.

How It Works

  • Magnesium ions released from magnesium sulfate heptahydrate serve as essential cofactors for numerous enzymatic reactions, competitively block calcium channels, promote vasodilation, and reduce neuronal excitability. In the cardiovascular system they stabilise myocardial membranes and suppress ectopic pacemaker activity, while in obstetrics they diminish uterine excitability and prevent seizure activity associated with severe preeclampsia.

Side Effects

Magnesium sulfate may cause a range of adverse reactions, from mild to severe.

Common Side Effects

  • Flushing or feeling of warmth
  • Nausea or vomiting
  • Headache
  • Mild hypotension

Serious or Rare Side Effects

  • Respiratory depression or arrest
  • Severe hypotension or cardiovascular collapse
  • Hypermagnesemia leading to cardiac arrhythmia
  • Anaphylactic or severe allergic reactions

Precautions & Warnings

Use magnesium sulfate with careful clinical monitoring and appropriate patient selection.

  • Serum magnesium monitoring: check levels before and during therapy to avoid toxicity.
  • Renal function assessment: adjust dosing in patients with impaired renal clearance.
  • Cardiac conduction disorders: use cautiously in patients with heart block or bradyarrhythmias.
  • Infusion rate: avoid rapid intravenous administration to reduce risk of hypotension.
  • Storage: Store at ambient temperature: keep in original container, protect from moisture and direct sunlight.

Avoid Interactions

Magnesium sulfate can interact with several drug classes, requiring attention to dosing and monitoring.

Major Interactions (Avoid)

  • Neuromuscular blocking agents: potentiates muscle relaxation and may cause prolonged paralysis.
  • Calcium channel blockers: additive vasodilatory effect can lead to severe hypotension.
  • Other magnesium‑containing products: risk of hypermagnesemia.

Moderate Interactions (Monitor Closely)

  • ACE inhibitors or ARBs: may enhance renal effects of magnesium.
  • Loop or thiazide diuretics: can alter magnesium balance, requiring serum level checks.

Frequently Asked Questions

Magnesium Sulfate Heptahydrate Kalceks is used to prevent and treat eclampsia and severe preeclampsia in pregnancy, to correct magnesium deficiency, and to manage torsades de pointes, a life‑threatening ventricular arrhythmia.

Magnesium sulfate provides magnesium ions that act as cofactors for many enzymes, block calcium channels, cause vasodilation, reduce neuronal excitability, and stabilise cardiac membranes, thereby preventing seizures, correcting electrolyte deficits, and terminating certain arrhythmias.

The specific dose and infusion rate are determined by the prescribing clinician based on the indication, patient weight, renal function, and serum magnesium levels. Healthcare professionals should follow local guidelines and monitor the patient closely.

Magnesium sulfate is commonly used in obstetric care for eclampsia and preeclampsia, but its safety profile depends on appropriate dosing and monitoring. Pregnant or breastfeeding patients should receive the drug only under direct medical supervision.

Submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain needs) and required import documentation.

Magnesium sulfate heptahydrate is a highly soluble form that can be administered intravenously or intramuscularly, offering rapid bioavailability. Compared with oral magnesium salts, it provides faster correction of severe deficiency and is the preferred choice for obstetric seizure prophylaxis and acute arrhythmia management.

Store the injectable solution at ambient temperature, ideally below 25 °C, in its original sealed container. Protect it from moisture, direct sunlight and extreme temperature fluctuations to maintain potency and sterility.

The drug is supplied as a sterile injectable solution for intramuscular or intravenous administration. Intravenous infusion should be performed slowly, usually over 15–30 minutes, while intramuscular injection is given into a large muscle group according to clinical protocol.

Serious risks include respiratory depression, severe hypotension, cardiac arrest, hypermagnesemia leading to arrhythmias, and rare anaphylactic reactions. Continuous monitoring of vital signs and serum magnesium levels is essential during therapy.

Patients with known hypersensitivity to magnesium sulfate, severe renal impairment, existing heart block or severe cardiac conduction disorders, and those receiving other high‑dose magnesium products should avoid this medication unless closely supervised by a physician.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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