Product image of Magnesium Sulfate Kalceks (Magnesium Sulfate Heptahydrate) supplied by GNH India

Magnesium Sulfate Kalceks

Active Ingredient:
Magnesium Sulfate Heptahydrate
Origin:
EU

Magnesium Sulfate Kalceks (Magnesium Sulfate Heptahydrate)

Magnesium sulfate, the active ingredient in Magnesium Sulfate Kalceks, is a magnesium salt presented as an injection solution for intramuscular and intravenous use. It is employed to replace magnesium electrolytes and to manage conditions such as eclampsia, severe preeclampsia, magnesium deficiency, torsades de pointes, and asthma exacerbation.

GNH India supplies Magnesium Sulfate Kalceks as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Kalceks

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Indications & Clinical Uses

Magnesium sulfate is used in obstetric, cardiac and respiratory care to correct magnesium deficiency and related disorders.

  • Eclampsia: prevents and controls seizures in pregnant women with this condition.
  • Severe preeclampsia: stabilises blood pressure and reduces risk of convulsions.
  • Magnesium deficiency: restores normal serum magnesium levels.
  • Torsades de pointes: terminates this ventricular tachyarrhythmia.
  • Asthma exacerbation: relaxes bronchial smooth muscle to improve airflow.

How It Works

  • Magnesium sulfate dissociates to release Mg2+ ions that act as calcium antagonists, stabilising cell membranes, inhibiting neuromuscular transmission, and causing vasodilation. The increased extracellular magnesium reduces neuronal excitability, diminishes acetylcholine release at the neuromuscular junction, and relaxes smooth muscle, thereby exerting anticonvulsant, anti‑arrhythmic and bronchodilatory effects.

Side Effects

Adverse reactions may occur with magnesium sulfate administration.

Common Side Effects

  • Flushing or feeling of warmth.
  • Nausea or vomiting.
  • Hypotension.
  • Muscle weakness or fatigue.
  • Headache.

Serious or Rare Side Effects

  • Respiratory depression or arrest.
  • Severe hypotension leading to shock.
  • Cardiac arrhythmias, including heart block.
  • Hypermagnesemia with neurological impairment.
  • Anaphylactic or severe allergic reactions.

Precautions & Warnings

Magnesium sulfate requires careful monitoring and specific safety measures.

  • Serum magnesium monitoring: check levels before and during therapy.
  • Renal impairment: adjust dose or avoid rapid infusion.
  • Cardiac conduction disorders: avoid in patients with heart block.
  • Neuromuscular disease: use cautiously in myasthenia gravis.
  • Concomitant neuromuscular blockers: may potentiate effects.
  • Store at controlled room temperature: keep in original container, protect from light and moisture.

Avoid Interactions

Magnesium sulfate can interact with several medicines, altering efficacy or safety.

Major Interactions (Avoid)

  • Calcium channel blockers: additive vasodilatory effect may cause severe hypotension.
  • Other magnesium‑containing products: risk of hypermagnesemia.
  • Aminoglycoside antibiotics: increased risk of neuromuscular blockade.

Moderate Interactions (Monitor Closely)

  • ACE inhibitors or ARBs: monitor blood pressure and renal function.
  • Loop or thiazide diuretics: may affect magnesium balance.
  • Anticoagulants: monitor for bleeding if high doses are used.

Frequently Asked Questions

Magnesium Sulfate Kalceks is used to treat magnesium deficiency and to manage obstetric emergencies such as eclampsia and severe preeclampsia, as well as cardiac arrhythmias like torsades de pointes and severe asthma exacerbations where bronchodilation is needed.

Magnesium sulfate releases magnesium ions that act as calcium antagonists, stabilising neuronal membranes, reducing neuromuscular transmission, causing vasodilation, and relaxing smooth muscle. These actions provide anticonvulsant, anti‑arrhythmic, and bronchodilatory effects.

The dose of Magnesium Sulfate Kalceks is determined by the prescribing clinician based on the specific indication, patient weight, renal function and serum magnesium levels. Only a qualified health professional should set the dosing regimen.

Magnesium sulfate is commonly used in pregnancy for conditions such as eclampsia, but safety depends on clinical judgment. Information on breastfeeding is limited; clinicians should weigh potential benefits against risks and consider alternative therapies when appropriate.

To order, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain if needed) and import documentation.

Magnesium Sulfate Kalceks is an injectable magnesium salt, offering rapid serum level correction compared with oral magnesium salts that have slower absorption. It is preferred in acute settings such as eclampsia or severe arrhythmias where immediate therapeutic effect is required.

The product should be stored at controlled room temperature, kept in its original packaging, protected from light and moisture, and inspected for particulate matter before use. Do not freeze or expose to extreme temperatures.

Magnesium Sulfate Kalceks is administered by intramuscular or intravenous injection under the supervision of a qualified health professional. The route, rate and duration are determined by the clinical indication and patient response.

Serious risks include respiratory depression, severe hypotension, cardiac arrhythmias such as heart block, hypermagnesemia leading to neurological impairment, and rare anaphylactic reactions. Continuous monitoring of vital signs and serum magnesium is essential during therapy.

Patients with known hypersensitivity to magnesium sulfate, existing heart block, severe renal failure, or uncontrolled myasthenia gravis should generally avoid this medication unless the benefits outweigh the risks and close monitoring is possible.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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