Product image of Magnesium Sulfate Kalceks (Magnesium Sulfate Heptahydrate) supplied by GNH India

Magnesium Sulfate Kalceks

Active Ingredient:
Magnesium Sulfate Heptahydrate
Origin:
EU

Magnesium Sulfate Kalceks (Magnesium Sulfate Heptahydrate)

Magnesium sulfate, the active ingredient in Magnesium Sulfate Kalceks, is a magnesium salt presented as a solution for injection for intramuscular, intravenous, subcutaneous use. It treats magnesium deficiency and related conditions such as eclampsia, torsades de pointes, severe asthma, and provides neuroprotection in preterm labor.

GNH India supplies Magnesium Sulfate Kalceks as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, transplant centres, oncology centres, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Kalceks

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Indications & Clinical Uses

Magnesium sulfate is used in several clinical situations involving electrolyte imbalance and neuromuscular excitability.

  • Magnesium deficiency: restores normal magnesium levels and supports cellular function.
  • Eclampsia prevention and treatment: reduces seizure risk in pregnant patients with pre‑eclampsia.
  • Torsades de pointes: stabilises cardiac repolarisation and terminates ventricular tachyarrhythmia.
  • Severe asthma exacerbations: promotes bronchodilation and improves airflow.
  • Preterm labor neuroprotection: protects the fetal brain by mitigating excitotoxic injury.

How It Works

  • Magnesium sulfate dissociates to release Mg2+ ions that competitively antagonise calcium at voltage‑gated channels, causing smooth‑muscle relaxation, vasodilation, and inhibition of acetylcholine release at the neuromuscular junction. The resulting reduction in intracellular calcium dampens neuronal excitability, providing anticonvulsant and anti‑arrhythmic effects while supporting electrolyte balance.

Side Effects

Adverse reactions may range from mild to severe and should be monitored during therapy.

Common Side Effects

  • Flushing or warmth at the infusion site
  • Nausea or vomiting
  • Headache
  • Hypotension
  • Sweating
  • Dizziness

Serious or Rare Side Effects

  • Respiratory depression or arrest
  • Severe hypotension leading to shock
  • Cardiac arrhythmias or cardiac arrest
  • Hypermagnesemia with loss of deep‑tendon reflexes
  • Muscle weakness or paralysis
  • Central nervous system depression

Precautions & Warnings

Magnesium sulfate requires careful assessment before and during administration.

  • Renal impairment: adjust dose or avoid if severe renal failure.
  • Cardiac disease: monitor ECG and blood pressure closely.
  • Neuromuscular disorders: use with caution in myasthenia gravis or spinal cord injury.
  • Concurrent calcium channel blockers: increased risk of profound hypotension.
  • Serum magnesium monitoring: check levels regularly to avoid toxicity.
  • Store at ambient temperature: keep in original container, protect from light and moisture.

Avoid Interactions

Magnesium sulfate can interact with several medicines, altering efficacy or safety.

Major Interactions (Avoid)

  • Calcium channel blockers: may cause excessive vasodilation and hypotension.
  • Neuromuscular blocking agents: potentiates muscle relaxation, risking respiratory failure.
  • Aminoglycoside antibiotics: increased risk of neuromuscular blockade.
  • Other magnesium‑containing products: risk of hypermagnesemia.

Moderate Interactions (Monitor Closely)

  • ACE inhibitors or ARBs: may enhance hypotensive effect.
  • Loop diuretics: can cause rapid shifts in electrolytes.
  • Digoxin: altered serum potassium may affect cardiac toxicity.
  • NSAIDs: may impair renal clearance of magnesium.

Frequently Asked Questions

Magnesium Sulfate Kalceks is an injectable magnesium salt used to correct magnesium deficiency, prevent and treat eclampsia, manage torsades de pointes, assist in severe asthma exacerbations, and provide neuroprotection for preterm infants. It works by supplying magnesium ions that influence muscle, nerve, and cardiac function.

Magnesium sulfate releases Mg2+ ions that act as calcium antagonists at voltage‑gated channels. This leads to smooth‑muscle relaxation, vasodilation, reduced neuronal excitability, and stabilization of cardiac electrical activity, which together address electrolyte deficits and seizure risk.

The specific dose and infusion rate are determined by the prescribing clinician based on the patient’s condition, weight, renal function, and therapeutic goal. Healthcare professionals calculate the appropriate regimen and monitor serum magnesium levels throughout treatment.

Magnesium sulfate is commonly used in obstetric care, particularly for eclampsia prevention, but its safety profile in pregnancy is classified as unknown in some regions. It should only be used when clearly indicated and under medical supervision. Breastfeeding mothers should consult their physician, as limited data are available on excretion in milk.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain if needed), and necessary import documentation.

Magnesium Sulfate Kalceks is a sterile injectable solution, offering rapid systemic magnesium delivery compared with oral magnesium salts that have slower absorption and variable bioavailability. Its formulation is suitable for intravenous, intramuscular, or subcutaneous routes, providing precise control of plasma magnesium levels in acute settings.

The product should be stored at ambient temperature, protected from light and moisture, and kept in its original sealed container. Do not freeze the solution. Before use, inspect for particulate matter or discoloration and allow the vial to reach room temperature if refrigerated during transport.

Magnesium Sulfate Kalceks is administered by a qualified healthcare professional via intramuscular, intravenous, or subcutaneous injection. The route, infusion rate, and duration depend on the clinical indication and patient response, with continuous monitoring of vital signs and serum magnesium levels.

Serious risks include respiratory depression, severe hypotension, cardiac arrest, hypermagnesemia leading to loss of deep‑tendon reflexes, and profound muscle weakness. Prompt recognition of these signs and immediate cessation of infusion, along with supportive measures, are essential.

Patients with severe renal failure, uncontrolled heart block, myasthenia gravis, or known hypersensitivity to magnesium sulfate should avoid this product. It is also contraindicated in individuals receiving high doses of other magnesium‑containing agents without appropriate monitoring.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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