Product image of Magnesium Sulfate Kalceks (Magnesium Sulfate Heptahydrate) supplied by GNH India

Magnesium Sulfate Kalceks

Active Ingredient:
Magnesium Sulfate Heptahydrate
Origin:
EU

Magnesium Sulfate Kalceks (Magnesium Sulfate Heptahydrate)

Magnesium sulfate, the active ingredient in Magnesium Sulfate Kalceks, is an electrolyte/mineral supplement presented as an injection solution for intramuscular, intravenous, and subcutaneous use. It is employed to replace deficient magnesium levels and to manage conditions such as eclampsia, severe preeclampsia, torsades de pointes, and acute asthma exacerbations.

GNH India supplies Magnesium Sulfate Kalceks as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals worldwide. The company adheres to stringent quality standards and provides reliable logistics for global distribution. Clients benefit from consistent product availability and regulatory compliance across regions.

Manufacturer / TM Owner

Kalceks

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Indications & Clinical Uses

Magnesium sulfate is used in obstetric, cardiac and respiratory care to restore magnesium balance and prevent complications.

  • Eclampsia: prevents seizures by stabilizing neuronal excitability in pregnant patients with severe hypertension.
  • Severe preeclampsia: reduces risk of progression to eclampsia through magnesium supplementation.
  • Magnesium deficiency: restores normal serum magnesium levels and supports neuromuscular function.
  • Torsades de pointes: shortens QT interval and helps terminate ventricular arrhythmias.
  • Asthma exacerbations: relaxes bronchial smooth muscle, improving airflow during severe attacks.

How It Works

  • Magnesium sulfate acts as a calcium antagonist and NMDA receptor blocker, producing vasodilation and reducing neuronal excitability. By competing with calcium at voltage‑gated channels, it stabilizes cardiac membranes and diminishes excitatory neurotransmitter release. The drug also modulates intracellular ATP activity, contributing to its anticonvulsant, anti‑arrhythmic, and bronchodilatory effects.

Side Effects

Magnesium sulfate may cause a range of adverse reactions, varying from mild to severe.

Common Side Effects

  • Flushing: transient warmth and redness of the skin.
  • Sweating: increased perspiration.
  • Nausea: mild stomach upset.
  • Injection site pain: local discomfort or erythema.

Serious or Rare Side Effects

  • Respiratory depression: reduced breathing effort, especially with high doses.
  • Cardiac arrest: severe bradycardia or arrhythmia leading to cardiac failure.
  • Hypermagnesemia: elevated serum magnesium causing muscle weakness, loss of reflexes, or cardiac conduction abnormalities.
  • Seizures: paradoxical convulsions in rare cases.

Precautions & Warnings

When using Magnesium Sulfate Kalceks, clinicians should consider several safety measures.

  • Renal impairment: monitor serum magnesium and adjust dosing.
  • Neuromuscular disease: use cautiously as magnesium may exacerbate weakness.
  • Cardiac disease: avoid rapid infusion in patients with heart block.
  • Pregnancy: limit use to situations where benefits outweigh potential risks.
  • Drug interactions: review concomitant medications that affect calcium or magnesium levels.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Magnesium sulfate can interact with several medicines, requiring careful assessment.

Major Interactions (Avoid)

  • Calcium channel blockers: additive hypotensive effect.
  • Neuromuscular blocking agents: prolonged paralysis.
  • Quinidine: increased risk of arrhythmia.

Moderate Interactions (Monitor Closely)

  • Aminoglycoside antibiotics: enhanced nephrotoxicity.
  • Loop diuretics: may increase magnesium loss.
  • ACE inhibitors: potential for hyperkalemia when combined with magnesium.

Frequently Asked Questions

Magnesium Sulfate Kalceks is an injectable electrolyte supplement used to treat magnesium deficiency, prevent seizures in eclampsia and severe preeclampsia, manage torsades de pointes ventricular arrhythmias, and aid bronchodilation during acute asthma attacks. It is administered by a qualified health professional in hospital or clinical settings.

Magnesium sulfate works by antagonizing calcium at voltage‑gated channels, blocking NMDA receptors, and causing vasodilation. These actions reduce neuronal excitability, stabilize cardiac membranes, and relax smooth muscle, which together help control seizures, correct arrhythmias, and improve airway tone during severe bronchospasm.

The specific dose and infusion rate are determined by the prescribing clinician based on the patient’s condition, weight, renal function, and therapeutic goals. Dosing regimens vary for obstetric emergencies, cardiac arrhythmias, or magnesium deficiency, and should follow local clinical guidelines.

Magnesium sulfate is commonly used in pregnancy for eclampsia and preeclampsia when the benefits outweigh potential risks. Safety data for breastfeeding are limited, but small amounts may be excreted in milk. Clinicians should evaluate each case individually and follow obstetric recommendations.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain if needed), and import documentation.

Magnesium Sulfate Kalceks is an injectable formulation, offering rapid systemic availability compared with oral magnesium salts, which have slower absorption and gastrointestinal side effects. Compared with calcium gluconate, magnesium provides direct anticonvulsant and anti‑arrhythmic effects, though both may be used together in specific cardiac protocols.

The product should be stored refrigerated at 2‑8 °C, protected from light, and must not be frozen or shaken. Before use, inspect the vial for particulate matter or discoloration, and allow it to reach room temperature if required for injection, following aseptic technique.

Administration is performed by a qualified health professional via intramuscular, intravenous, or subcutaneous injection. The route and infusion speed are chosen according to the clinical indication, with careful monitoring of vital signs and serum magnesium levels during and after administration.

Serious risks include respiratory depression, severe hypotension, cardiac arrest, and hypermagnesemia leading to loss of deep tendon reflexes or cardiac conduction disturbances. Prompt recognition of these signs and immediate medical intervention are essential.

Patients with known hypersensitivity to magnesium sulfate, severe renal failure without dialysis, existing heart block, or uncontrolled myasthenia gravis should avoid this product unless a specialist determines that benefits outweigh risks.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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