Product image of Magnesium Sulfate Kalceks (Magnesium Sulfate Heptahydrate) supplied by GNH India

Magnesium Sulfate Kalceks

Active Ingredient:
Magnesium Sulfate Heptahydrate
Origin:
EU

Magnesium Sulfate Kalceks (Magnesium Sulfate Heptahydrate)

Magnesium Sulfate Heptahydrate, the active ingredient in Magnesium Sulfate Kalceks, is an electrolyte supplement presented as an injectable solution for intramuscular, intravenous, or subcutaneous use. It is employed to prevent and treat eclampsia in pregnant women and to correct severe hypomagnesemia.

GNH India supplies Magnesium Sulfate Kalceks as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Kalceks

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Indications & Clinical Uses

Magnesium sulfate is used in obstetric and electrolyte‑replacement pathways to manage specific acute conditions.

  • Eclampsia: prevents and treats seizures associated with pre‑eclampsia/eclampsia in pregnant patients.
  • Severe hypomagnesemia: restores normal serum magnesium concentrations in patients with critically low levels.
  • Torsades de pointes (rarely): may be used as an adjunct to stabilize cardiac rhythm when magnesium deficiency is implicated.

How It Works

  • Magnesium acts as a calcium antagonist, stabilizing cell membranes and inhibiting NMDA receptors while reducing acetylcholine release. These actions produce vasodilation, bronchodilation, and anticonvulsant effects. By competing with calcium at voltage‑gated channels, magnesium diminishes neuronal excitability and smooth‑muscle contraction, facilitating seizure control and correction of electrolyte imbalance.

Side Effects

Magnesium sulfate may cause a range of adverse reactions, which are grouped by frequency.

Common Side Effects

  • Flushing or feeling of warmth.
  • Sweating.
  • Nausea or vomiting.
  • Hypotension.
  • Injection‑site pain or irritation.
  • Headache.

Serious or Rare Side Effects

  • Respiratory depression or arrest.
  • Severe hypotension leading to shock.
  • Cardiac arrhythmias, including bradycardia.
  • Hypermagnesemia with neuromuscular blockade.
  • Loss of deep tendon reflexes.
  • Cardiac arrest.

Precautions & Warnings

Magnesium sulfate requires careful monitoring in several clinical situations.

  • Renal impairment: monitor serum magnesium and adjust dose.
  • Cardiac disease: use cautiously; watch for bradycardia and hypotension.
  • Neuromuscular disorders: increased risk of muscle weakness.
  • Pregnancy: administer only when maternal benefit outweighs fetal risk.
  • Concomitant calcium‑containing solutions: avoid simultaneous infusion.
  • Store below 25°C: keep in original container, protect from moisture.

Avoid Interactions

Magnesium sulfate can interact with several drug classes, necessitating vigilance.

Major Interactions (Avoid)

  • Calcium‑containing IV solutions: may precipitate and cause embolism.
  • Aminoglycoside antibiotics: potentiates neuromuscular blockade.
  • Neuromuscular blocking agents: risk of prolonged paralysis.

Moderate Interactions (Monitor Closely)

  • ACE inhibitors or ARBs: may increase risk of hypermagnesemia.
  • Potassium‑sparing diuretics: monitor electrolyte balance.
  • Other magnesium‑containing products: avoid cumulative excess.

Frequently Asked Questions

Magnesium Sulfate Kalceks is an injectable electrolyte supplement used primarily to prevent and treat seizures in eclampsia and to correct severe hypomagnesemia, a condition where blood magnesium levels are critically low.

Magnesium sulfate acts as a calcium antagonist, stabilizing cell membranes, inhibiting NMDA receptors, and reducing acetylcholine release. These actions lead to vasodilation, bronchodilation, and anticonvulsant effects, helping control seizures and restore normal magnesium balance.

The dosage of Magnesium Sulfate Kalceks is determined by the prescribing clinician based on the patient’s condition, severity, renal function, and route of administration. Healthcare professionals set the appropriate dose and infusion rate.

Magnesium sulfate is classified as a pregnancy‑category drug only when the therapeutic benefit to the mother outweighs potential fetal risk. It is commonly used in obstetric care for eclampsia. Safety during breastfeeding has not been definitively established, so clinical judgment is required.

To order, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain if needed), and import documentation.

Compared with other anticonvulsant agents, magnesium sulfate uniquely combines calcium‑antagonist activity with direct membrane stabilization, making it the preferred choice for eclampsia. Other electrolytes, such as calcium gluconate, do not provide the same seizure‑preventing properties.

Magnesium Sulfate Kalceks should be stored below 25 °C, protected from moisture and direct sunlight, and kept in its original packaging. Before use, inspect the solution for particulate matter or discoloration and ensure aseptic technique during preparation.

The product is administered by a qualified healthcare professional via intramuscular, intravenous, or subcutaneous injection. The route, infusion rate, and concentration are selected according to the clinical indication and patient’s physiological status.

Serious risks include respiratory depression, severe hypotension, cardiac arrhythmias, hypermagnesemia leading to neuromuscular blockade, and loss of deep tendon reflexes. Prompt monitoring of vital signs and serum magnesium levels is essential to mitigate these hazards.

Patients with known hypersensitivity to magnesium sulfate, severe renal failure without appropriate monitoring, or those receiving concurrent calcium‑containing IV solutions should avoid this medication unless benefits clearly outweigh risks.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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