Product image of Magnesium Sulfate Kalceks (Magnesium Sulfate Heptahydrate) supplied by GNH India

Magnesium Sulfate Kalceks

Active Ingredient:
Magnesium Sulfate Heptahydrate
Origin:
EU

Magnesium Sulfate Kalceks (Magnesium Sulfate Heptahydrate)

Magnesium sulfate heptahydrate, the active ingredient in Magnesium Sulfate Kalceks, is a magnesium compound presented as an injection solution for intramuscular, intravenous, subcutaneous use. It treats magnesium deficiency and related conditions in patients such as those with hypomagnesemia, obstetric complications, and certain cardiac arrhythmias.

GNH India supplies Magnesium Sulfate Kalceks as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, transplant centres, oncology centres, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Kalceks

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Indications & Clinical Uses

Magnesium sulfate heptahydrate is used in magnesium replacement therapy to correct low serum magnesium levels and related disorders.

  • Hypomagnesemia: restores normal serum magnesium concentrations and supports neuromuscular function.
  • Eclampsia and pre‑eclampsia: provides magnesium ions that prevent seizures and stabilize blood pressure in obstetric patients.
  • Torsades de pointes and other cardiac arrhythmias: helps normalize cardiac excitability and rhythm.
  • Severe asthma exacerbations: induces bronchodilation and reduces airway hyper‑responsiveness.
  • Magnesium deficiency in obstetric patients: corrects maternal magnesium loss and protects fetal health.

How It Works

  • Magnesium sulfate heptahydrate dissociates to release Mg2+ ions that serve as essential cofactors for numerous enzymatic reactions, stabilize neuromuscular transmission, and modulate calcium influx. At therapeutic concentrations, magnesium acts as a vasodilator and anticonvulsant by antagonizing NMDA receptors and inhibiting voltage‑gated calcium channels, thereby reducing neuronal excitability and smooth‑muscle contraction.

Side Effects

Adverse reactions may occur following administration of magnesium sulfate injection.

Common Side Effects

  • Flushing or warmth at the injection site
  • Nausea or vomiting
  • Mild hypotension
  • Headache
  • Injection‑site pain or erythema
  • Sweating or feeling of warmth

Serious or Rare Side Effects

  • Severe hypotension or cardiovascular collapse
  • Respiratory depression or arrest
  • Hypermagnesemia leading to muscle weakness or cardiac arrhythmia
  • Anaphylactic or severe allergic reaction
  • Cardiac arrest
  • Profound neuromuscular blockade

Precautions & Warnings

Magnesium sulfate should be used with careful clinical monitoring.

  • Renal impairment: monitor serum magnesium and adjust dose.
  • Cardiac disease: observe ECG and blood pressure closely.
  • Pregnancy: evaluate risk‑benefit, especially in pre‑eclampsia.
  • Concomitant neuromuscular blocking agents: may potentiate blockade.
  • Calcium‑containing solutions: avoid simultaneous administration to prevent precipitation.
  • Store below 25°C: keep in original container, protect from moisture and light.

Avoid Interactions

Magnesium sulfate can interact with several medicines; awareness of interaction severity guides clinical decisions.

Major Interactions (Avoid)

  • Calcium‑containing solutions: risk of insoluble precipitate.
  • Neuromuscular blocking agents: enhanced muscle relaxation.
  • Potassium‑sparing diuretics: increased risk of hypermagnesemia.

Moderate Interactions (Monitor Closely)

  • ACE inhibitors: additive hypotensive effect.
  • Loop diuretics: may increase magnesium loss.
  • Aminoglycoside antibiotics: potential for increased neuromuscular blockade.

Frequently Asked Questions

Magnesium Sulfate Kalceks is an injectable magnesium sulfate heptahydrate solution used to correct magnesium deficiency and to manage conditions such as hypomagnesemia, eclampsia or pre‑eclampsia, certain cardiac arrhythmias, severe asthma attacks, and magnesium depletion in obstetric patients.

The compound releases magnesium ions that act as cofactors for many enzymes, stabilize neuromuscular transmission, and at higher concentrations cause vasodilation and anticonvulsant effects by blocking calcium channels and modulating NMDA receptors, thereby restoring normal cellular function.

The specific dose and infusion rate are determined by the prescribing clinician based on the patient’s condition, serum magnesium level, renal function, and route of administration. Only a qualified health professional should set the dosing regimen.

Magnesium sulfate is commonly used in obstetric care, particularly for eclampsia and pre‑eclampsia, but safety depends on the clinical situation. The prescriber should weigh potential benefits against risks, and breastfeeding mothers should consult their healthcare provider.

Submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain if needed) and import documentation.

Magnesium Sulfate Kalceks provides magnesium in the heptahydrate form, which is highly soluble for rapid intravenous, intramuscular or subcutaneous delivery. Compared with oral magnesium salts, the injectable route achieves faster serum level correction, which is essential in acute emergencies such as eclampsia or severe arrhythmias.

The product should be stored below 25 °C, protected from moisture and direct light, and kept in its original sealed container. Do not freeze the solution and avoid shaking vigorously to maintain sterility and solution clarity.

It is administered by a qualified healthcare professional via intramuscular, intravenous, or subcutaneous injection. The route, infusion speed, and dilution (if any) are selected according to the indication and patient’s clinical status.

Serious risks include severe hypotension, respiratory depression, cardiac arrest, hypermagnesemia leading to muscle weakness or arrhythmias, and rare anaphylactic reactions. Continuous monitoring of vital signs and serum magnesium levels is essential during administration.

Patients with known hypersensitivity to magnesium sulfate, severe renal failure without appropriate monitoring, or those receiving incompatible calcium‑containing solutions should avoid this product unless a prescriber determines that benefits outweigh risks.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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