Product image of Magnesium Sulfate Kalceks (Magnesium Sulfate Heptahydrate) supplied by GNH India

Magnesium Sulfate Kalceks

Active Ingredient:
Magnesium Sulfate Heptahydrate
Origin:
EU

Magnesium Sulfate Kalceks (Magnesium Sulfate Heptahydrate)

Magnesium sulfate, the active ingredient in Magnesium Sulfate Kalceks, is an electrolyte presented as a solution for injection for intravenous and subcutaneous use. It treats magnesium deficiency and related conditions such as eclampsia, cardiac arrhythmias, and severe asthma exacerbations in hospitalized patients.

GNH India supplies Magnesium Sulfate Kalceks as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals worldwide.

Manufacturer / TM Owner

Kalceks

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Indications & Clinical Uses

Magnesium Sulfate Kalceks is used to correct magnesium deficits and to manage conditions where magnesium plays a therapeutic role.

  • Magnesium deficiency: restores normal serum magnesium levels and supports enzymatic functions.
  • Eclampsia and preeclampsia: prevents seizures by stabilising neuronal excitability.
  • Torsades de pointes: reduces ventricular ectopy by correcting electrolyte imbalance.
  • Severe asthma exacerbations: promotes bronchodilation through calcium antagonism.
  • Cardiac arrhythmias: assists in normalising cardiac conduction and rhythm.

How It Works

  • Magnesium sulfate provides magnesium ions that serve as essential cofactors for numerous enzymatic reactions, compete with calcium at voltage‑gated channels, and induce vasodilation. By antagonising calcium‑mediated processes, it stabilises neuronal membranes, relaxes smooth muscle, and supports cardiac electrophysiology, thereby correcting electrolyte disturbances and mitigating hyperexcitability.

Side Effects

Adverse reactions may occur with magnesium sulfate administration.

Common Side Effects

  • Flushing or warmth at the injection site.
  • Mild hypotension or transient blood pressure drop.
  • Nausea or mild gastrointestinal discomfort.
  • Headache or dizziness.
  • Local irritation or pain at the injection site.

Serious or Rare Side Effects

  • Respiratory depression or apnea, especially with rapid IV bolus.
  • Cardiac arrest or severe bradycardia.
  • Hypermagnesemia leading to muscle weakness, loss of deep tendon reflexes, or arrhythmias.
  • Allergic reactions such as rash, urticaria, or anaphylaxis.
  • Severe hypotension unresponsive to fluids.

Precautions & Warnings

Magnesium sulfate should be used with careful clinical monitoring.

  • Renal impairment: assess serum magnesium and adjust infusion rate.
  • Cardiac disease: monitor ECG and blood pressure continuously.
  • Neuromuscular disorders: watch for enhanced muscle weakness.
  • Concomitant calcium channel blockers: avoid additive hypotensive effects.
  • Pregnancy and lactation: use only if clearly indicated and benefits outweigh risks.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Magnesium sulfate may interact with several medications.

Major Interactions (Avoid)

  • Calcium channel blockers: additive vasodilatory and hypotensive effects.
  • Neuromuscular blocking agents: potentiation of muscle relaxation.
  • Certain antibiotics (e.g., aminoglycosides): reduced absorption when given concurrently.

Moderate Interactions (Monitor Closely)

  • Loop diuretics: increased risk of hypomagnesemia.
  • Digoxin: potential for altered cardiac conduction.
  • Warfarin: possible enhancement of anticoagulant effect.
  • Antacids containing magnesium: cumulative magnesium load.

Frequently Asked Questions

Magnesium Sulfate Kalceks is an injectable electrolyte used to treat magnesium deficiency, prevent seizures in eclampsia and preeclampsia, manage torsades de pointes, assist in severe asthma exacerbations, and correct cardiac arrhythmias caused by low magnesium levels.

Magnesium sulfate releases magnesium ions that act as cofactors for many enzymes, antagonise calcium‑mediated signaling, promote vasodilation, and relax smooth and skeletal muscle. These actions help stabilise neuronal membranes, improve cardiac conduction, and support bronchodilation.

The dosage of Magnesium Sulfate Kalceks is determined by the prescribing clinician based on the patient’s condition, serum magnesium level, renal function, and route of administration. Healthcare professionals set the appropriate infusion rate or bolus amount.

Safety data for Magnesium Sulfate Kalceks in pregnancy and lactation are limited. It may be used when clearly indicated, such as for eclampsia, but the prescriber must weigh potential benefits against any unknown risks to the mother and fetus or infant.

To order, submit an enquiry on the product page at gnhindia.com with the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain where needed) and import documentation.

Magnesium Sulfate Kalceks is an injectable form offering rapid bioavailability, which is advantageous in acute settings such as eclampsia or severe arrhythmias. Oral magnesium salts are slower to act and may be less suitable for emergency correction of severe deficiency.

The product should be stored refrigerated at 2‑8 °C, protected from light, and must not be frozen or shaken. Keep the vial in its original packaging until use to maintain sterility and potency.

Magnesium Sulfate Kalceks is given by intravenous or subcutaneous injection. The route, rate, and total dose are prescribed by a qualified clinician, who monitors the patient’s vital signs and serum magnesium levels throughout therapy.

Serious risks include respiratory depression, severe hypotension, hypermagnesemia leading to muscle weakness, loss of reflexes, cardiac arrest, and rare anaphylactic reactions. Continuous monitoring is essential, especially during rapid IV administration.

Patients with known hypersensitivity to magnesium sulfate, severe renal failure without dialysis capability, or uncontrolled heart block should not receive this product unless a specialist determines that benefits outweigh the risks.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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