Product image of Magnesium Sulfuricum Bbp (Magnesium Sulfate Heptahydrate) supplied by GNH India

Magnesium Sulfuricum Bbp

Active Ingredient:
Magnesium Sulfate Heptahydrate
Origin:
EU

Magnesium Sulfuricum Bbp (Magnesium Sulfate Heptahydrate)

Magnesium sulfate, the active ingredient in Magnesium Sulfuricum Bbp, is an electrolyte supplement presented as a sterile solution for intramuscular, intravenous, and subcutaneous use. It is employed to correct magnesium deficiency and to manage conditions such as pre‑eclampsia, torsades de pointes, and severe asthma exacerbations in hospitalized patients.

GNH India supplies Magnesium Sulfuricum Bbp as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Bb Pharma A.S.

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Indications & Clinical Uses

Magnesium Sulfate is used in several clinical situations where magnesium homeostasis is critical.

  • Magnesium deficiency: restores normal serum magnesium concentrations and alleviates related neuromuscular symptoms.
  • Pre‑eclampsia/eclampsia: prevents seizures by counteracting calcium‑mediated excitability in the central nervous system.
  • Torsades de pointes: stabilises cardiac repolarisation and reduces the risk of ventricular arrhythmias.
  • Severe asthma exacerbations: relaxes bronchial smooth muscle, improving airflow in acute attacks.

How It Works

  • Magnesium sulfate dissociates to release magnesium ions that serve as essential cofactors for numerous enzymatic reactions, stabilise cell membranes, and antagonise calcium‑mediated excitability. By competing with calcium at voltage‑gated channels, it reduces neuronal firing, smooth‑muscle contraction, and cardiac depolarisation, thereby exerting anti‑arrhythmic, vasodilatory, and bronchodilatory effects.

Side Effects

Magnesium Sulfate may cause a range of adverse reactions, from mild to severe.

Common Side Effects

  • Flushing or warmth at the injection site.
  • Nausea or vomiting.
  • Headache.
  • Hypotension due to vasodilation.
  • Transient facial flushing.
  • Mild muscle weakness.

Serious or Rare Side Effects

  • Respiratory depression or arrest, especially with rapid IV administration.
  • Cardiac arrest or severe bradycardia.
  • Hypermagnesemia leading to loss of deep tendon reflexes.
  • Severe hypotension unresponsive to fluids.
  • Allergic reactions including anaphylaxis.
  • Local tissue necrosis if extravasation occurs.

Precautions & Warnings

Magnesium Sulfate should be administered with careful clinical monitoring.

  • Renal impairment: monitor serum magnesium and adjust dosing.
  • Cardiac disease: observe ECG for prolonged QT or bradyarrhythmias.
  • Neuromuscular disorders: avoid high doses in patients with myasthenia gravis.
  • Concomitant calcium therapy: separate administration times to prevent precipitation.
  • Pregnancy: use only when clearly needed, as benefits must outweigh potential risks.
  • Store below 25°C: keep in original container, protect from moisture and light.

Avoid Interactions

Magnesium Sulfate can interact with several drug classes, altering efficacy or safety.

Major Interactions (Avoid)

  • Calcium‑containing IV solutions: risk of precipitation and reduced magnesium availability.
  • Potent neuromuscular blocking agents (e.g., succinylcholine, non‑depolarizing blockers): may cause prolonged paralysis.
  • Certain antibiotics (e.g., tetracyclines, quinolones): reduced absorption when given orally.

Moderate Interactions (Monitor Closely)

  • Loop diuretics: increase renal magnesium loss, requiring closer monitoring.
  • ACE inhibitors or ARBs: additive hypotensive effect.
  • Digoxin: heightened risk of arrhythmias with concurrent hypermagnesemia.
  • Other QT‑prolonging drugs: monitor cardiac rhythm for additive effects.

Frequently Asked Questions

Magnesium Sulfuricum Bbp is an injectable magnesium sulfate preparation used to correct magnesium deficiency, prevent seizures in pre‑eclampsia/eclampsia, treat torsades de pointes arrhythmias, and provide bronchodilation in severe asthma attacks. It is administered in hospital settings under physician supervision.

Magnesium sulfate releases magnesium ions that act as cofactors for many enzymes, stabilize cell membranes, and antagonize calcium‑mediated excitability. This results in vasodilation, reduced neuronal firing, relaxation of smooth muscle, and stabilization of cardiac electrical activity, addressing the conditions for which it is prescribed.

The appropriate dose of Magnesium Sulfuricum Bbp is determined by the prescribing clinician based on the patient’s condition, weight, renal function, and route of administration. Dosage regimens are individualized and should follow local clinical guidelines and the product’s prescribing information.

Magnesium sulfate may be used during pregnancy when the therapeutic benefit justifies potential risks, such as in pre‑eclampsia management. Safety in breastfeeding is not well established; clinicians should weigh benefits against possible exposure to the infant and monitor accordingly.

To order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifying trade or institutional credentials before providing pricing, availability, shipping details (including any cold‑chain requirements), and necessary import documentation.

Magnesium Sulfuricum Bbp provides magnesium sulfate in a sterile injectable form, allowing rapid correction of serum magnesium levels. Compared with oral magnesium salts, it offers faster onset and precise dosing for acute situations, but requires intravenous, intramuscular, or subcutaneous administration by qualified personnel.

Store the product below 25 °C in its original packaging, protecting it from moisture and direct light. Ensure the container is sealed, and avoid freezing. Follow standard aseptic techniques when preparing the solution for injection.

The preparation is administered by a healthcare professional via intramuscular, intravenous, or subcutaneous injection. The route, infusion rate, and volume are selected based on the clinical indication, patient condition, and prescribing guidelines.

Serious risks include respiratory depression or arrest, severe hypotension, cardiac arrest or profound bradycardia, hypermagnesemia with loss of deep tendon reflexes, and anaphylactic reactions. Prompt monitoring of vital signs and serum magnesium levels is essential during therapy.

Patients with known hypersensitivity to magnesium sulfate, severe renal impairment without appropriate monitoring, or those receiving high‑dose calcium therapy that cannot be separated in time should avoid this product. Clinicians must assess individual risk factors before prescribing.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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