Product image of Magnesium Sulphate Ethypharm (Magnesium Sulfate Heptahydrate) supplied by GNH India

Magnesium Sulphate Ethypharm

Active Ingredient:
Magnesium Sulfate Heptahydrate
Origin:
EU

Magnesium Sulphate Ethypharm (Magnesium Sulfate Heptahydrate)

Magnesium sulfate, the active ingredient in Magnesium Sulphate Ethypharm, is an electrolyte (magnesium salt) presented as an injection solution for intramuscular and intravenous use. It is employed to prevent and treat eclampsia, correct magnesium deficiency, manage certain ventricular arrhythmias and assist in severe asthma exacerbations.

GNH India supplies Magnesium Sulphate Ethypharm as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals worldwide.

Manufacturer / TM Owner

Ethypharm

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Indications & Clinical Uses

Magnesium Sulfate is used across several clinical pathways involving electrolyte balance and neuromuscular control.

  • Pre‑eclampsia/eclampsia: prevention and treatment of seizures in pregnant women with severe pre‑eclampsia or eclampsia.
  • Magnesium deficiency: rapid repletion of low serum magnesium levels.
  • Ventricular arrhythmias: control of torsades de pointes and other life‑threatening ventricular rhythms.
  • Severe asthma: adjunct therapy to relax bronchial smooth muscle during acute exacerbations.

How It Works

  • Magnesium sulfate acts as a calcium antagonist, competing with calcium at voltage‑gated channels and stabilising cell membranes. This reduces neuromuscular excitability, promotes vasodilation, and diminishes the release of acetylcholine at the neuromuscular junction, thereby exerting anticonvulsant and anti‑arrhythmic effects while aiding bronchodilation in severe asthma.

Side Effects

Adverse reactions may vary with dose, route and patient condition.

Common Side Effects

  • Flushing or warmth at the injection site
  • Sweating and feeling of heat
  • Nausea or mild vomiting
  • Hypotension or transient blood pressure drop
  • Muscle weakness or fatigue
  • Headache

Serious or Rare Side Effects

  • Respiratory depression or arrest
  • Severe hypotension leading to shock
  • Cardiac arrhythmias or cardiac arrest
  • Hypermagnesemia with neuromuscular blockade
  • Anaphylactic or severe allergic reactions
  • Local tissue necrosis if extravasation occurs

Precautions & Warnings

Magnesium Sulfate requires careful monitoring in specific clinical situations.

  • Assess renal function: avoid or adjust in severe renal impairment due to reduced clearance.
  • Monitor serum magnesium: maintain therapeutic range to prevent toxicity.
  • Evaluate cardiac status: watch for bradycardia or conduction abnormalities.
  • Use cautiously in patients with myasthenia gravis or other neuromuscular disorders.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Magnesium Sulfate can alter the activity of several co‑administered medicines.

Major Interactions (Avoid)

  • Neuromuscular blocking agents (e.g., succinylcholine, non‑depolarizing blockers): may cause prolonged paralysis.
  • Calcium channel blockers: additive hypotensive effect.
  • Other magnesium‑containing products: risk of hypermagnesemia.
  • Aminoglycoside antibiotics: enhanced neuromuscular blockade.
  • Potassium‑sparing diuretics: may increase serum magnesium levels.

Moderate Interactions (Monitor Closely)

  • Loop and thiazide diuretics: can affect magnesium balance.
  • ACE inhibitors or ARBs: monitor blood pressure and renal function.
  • Digoxin: watch for altered cardiac conduction.
  • Anticoagulants: potential for altered clotting parameters.
  • Certain anti‑epileptic drugs: may require dose adjustment.

Frequently Asked Questions

Magnesium Sulphate Ethypharm is indicated for the prevention and treatment of eclampsia and severe pre‑eclampsia in pregnancy, for rapid correction of magnesium deficiency, for managing torsades de pointes and other ventricular arrhythmias, and as an adjunct in severe asthma exacerbations to promote bronchodilation.

Magnesium sulfate acts as a calcium antagonist, blocking calcium entry into cells, stabilising membranes, reducing neuromuscular excitability, and causing vasodilation. These actions help control seizures, correct electrolyte imbalances, suppress abnormal cardiac rhythms, and relax bronchial smooth muscle.

The specific dose and infusion rate are determined by the prescribing clinician based on the indication, patient weight, renal function and clinical response. Healthcare professionals should follow local guidelines and monitor serum magnesium levels during therapy.

Magnesium sulfate is commonly used in pregnancy for eclampsia management and is considered relatively safe when administered under medical supervision. Limited data exist for breastfeeding, but small amounts are excreted in milk; clinicians should weigh benefits against potential risks.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain if needed) and necessary import documentation.

Compared with other anticonvulsant agents, magnesium sulfate offers a dual benefit of seizure control and electrolyte replacement, making it uniquely suited for eclampsia and certain arrhythmias. Unlike benzodiazepines, it does not cause respiratory depression at therapeutic levels, but it requires careful monitoring of serum magnesium and renal function.

Magnesium Sulphate Ethypharm injection solution should be stored at 2‑8 °C, protected from light, and kept in its original container. Do not freeze or shake the vial. If temperature excursions occur, discard the product according to local regulations.

The product is supplied as a sterile injection solution for intramuscular or intravenous administration. Intravenous infusion is typically given via a controlled infusion pump, while intramuscular injection is performed using standard aseptic technique. Administration routes and rates are dictated by the clinical indication and physician orders.

The most serious risks include hypermagnesemia leading to respiratory depression, severe hypotension, cardiac arrhythmias or arrest, and anaphylactic reactions. Prompt recognition of symptoms such as loss of deep tendon reflexes, respiratory compromise or profound hypotension is essential, and treatment should be initiated immediately.

Patients with severe renal impairment, known hypersensitivity to magnesium sulfate, myasthenia gravis, or those receiving potent neuromuscular blocking agents should avoid this medication unless closely monitored. Contraindications also include uncontrolled heart block or severe hypotension without appropriate resuscitative measures.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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