Product image of Magnesium Sulphate Phoenix Labs (Magnesium Sulfate) supplied by GNH India

Magnesium Sulphate Phoenix Labs

Active Ingredient:
Magnesium Sulfate
Origin:
EU

Magnesium Sulphate Phoenix Labs (Magnesium Sulfate)

Magnesium sulfate, the active ingredient in Magnesium Sulphate Phoenix Labs, is a magnesium salt presented as an injection for intramuscular and intravenous use. It is employed to treat eclampsia, severe preeclampsia, magnesium deficiency, torsades de pointes prophylaxis, and asthma exacerbations.

GNH India supplies Magnesium Sulphate Phoenix Labs as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals worldwide.

Manufacturer / TM Owner

Phoenix Labs

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Indications & Clinical Uses

Magnesium sulfate is used in obstetric, cardiac and respiratory conditions where electrolyte balance or neuromuscular control is critical.

  • Eclampsia: prevents and controls seizures in pregnant women with this condition.
  • Severe preeclampsia: stabilises blood pressure and reduces risk of convulsions.
  • Magnesium deficiency: restores normal serum magnesium levels.
  • Torsades de pointes prophylaxis: reduces the incidence of ventricular arrhythmias.
  • Asthma exacerbations: assists bronchodilation and improves airway responsiveness.

How It Works

  • Magnesium sulfate dissociates to release Mg2+ ions that act as calcium antagonists at voltage‑gated channels, producing vasodilation, neuromuscular blockade, and central nervous system depression. The resulting reduction in calcium influx diminishes neurotransmitter release and smooth‑muscle contraction, providing anticonvulsant and anti‑arrhythmic effects while supporting electrolyte homeostasis.

Side Effects

Adverse reactions may range from mild to severe and should be monitored during therapy.

Common Side Effects

  • Flushing or warmth at the injection site.
  • Nausea or vomiting.
  • Headache.
  • Mild hypotension.
  • Muscle weakness or fatigue.

Serious or Rare Side Effects

  • Respiratory depression or arrest.
  • Severe hypotension leading to shock.
  • Cardiac arrhythmias, including bradycardia.
  • Hypermagnesemia with neuromuscular paralysis.
  • Anaphylactic or severe allergic reactions.

Precautions & Warnings

Magnesium sulfate requires careful monitoring of patient status and laboratory values.

  • Serum magnesium monitoring: check levels before and during therapy to avoid toxicity.
  • Renal function assessment: adjust use in patients with impaired clearance.
  • Neuromuscular disease caution: patients with myasthenia gravis may experience exaggerated blockade.
  • Avoid rapid IV bolus: administer slowly to reduce cardiovascular effects.
  • Contraindicated in heart block without a pacemaker: may worsen conduction.
  • Store at below 25°C: keep in original container, protect from moisture and light.

Avoid Interactions

Magnesium sulfate can alter the activity of several co‑administered medicines.

Major Interactions (Avoid)

  • Calcium channel blockers: additive vasodilatory effect may cause profound hypotension.
  • Neuromuscular blocking agents: potentiates blockade, risking respiratory failure.
  • Other magnesium‑containing products: risk of hypermagnesemia.

Moderate Interactions (Monitor Closely)

  • ACE inhibitors: may enhance renal effects and potassium shifts.
  • Loop diuretics: increase magnesium loss, requiring dose adjustments.
  • Aminoglycoside antibiotics: may intensify neuromuscular weakness.

Frequently Asked Questions

Magnesium Sulphate Phoenix Labs is indicated for the management of eclampsia and severe preeclampsia in pregnancy, treatment of documented magnesium deficiency, prophylaxis of torsades de pointes ventricular arrhythmias, and as an adjunct in severe asthma exacerbations where bronchodilation is needed.

Magnesium sulfate releases magnesium ions that compete with calcium at voltage‑gated channels, leading to vasodilation, reduced neuromuscular transmission, and central nervous system depression. This calcium antagonism stabilises neuronal membranes, prevents seizures, and helps regulate cardiac rhythm while replenishing deficient magnesium stores.

The specific dose and infusion rate are determined by the prescribing clinician based on the indication, patient weight, renal function, and serum magnesium levels. Healthcare professionals tailor the regimen to achieve therapeutic targets while avoiding toxicity.

Magnesium sulfate is commonly used in obstetric care for eclampsia and preeclampsia, but its safety profile in pregnancy is classified as unknown in some regions. It should only be administered when the benefits outweigh potential risks, and breastfeeding mothers should consult their healthcare provider.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain if needed), and necessary import documentation.

Compared with alternatives such as diazepam or phenobarbital, magnesium sulfate offers a unique mechanism as a calcium antagonist, providing both anticonvulsant and vasodilatory effects. It is preferred in obstetric seizures because it does not cross the placenta in high concentrations and has a well‑established safety record for eclampsia.

Magnesium Sulphate Phoenix Labs should be stored at temperatures below 25 °C, in its original sealed container, protected from moisture and direct light. Do not freeze the solution, and keep it out of reach of children.

The product is supplied as a sterile injectable solution for intramuscular or intravenous administration. Intravenous infusion should be performed slowly, often after an initial loading dose, while intramuscular injection is given into a large muscle mass, following aseptic technique.

The most critical risks include severe hypotension, respiratory depression, cardiac arrhythmias, and hypermagnesemia leading to neuromuscular paralysis. Continuous monitoring of blood pressure, respiratory status, and serum magnesium levels is essential to detect and manage these complications promptly.

Patients with advanced heart block without a pacemaker, severe renal impairment, known hypersensitivity to magnesium sulfate, or those receiving high‑dose calcium channel blockers should avoid this medication unless closely supervised by a specialist.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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