Product image of Magnesiumsulfaat Kalceks (Magnesium Sulfate Heptahydrate) supplied by GNH India

Magnesiumsulfaat Kalceks

Active Ingredient:
Magnesium Sulfate Heptahydrate
Origin:
EU

Magnesiumsulfaat Kalceks (Magnesium Sulfate Heptahydrate)

Magnesium sulfate, the active ingredient in Magnesiumsulfaat Kalceks, is an electrolyte supplement presented as a sterile injectable solution for intramuscular, intravenous, and subcutaneous use. It is employed to correct magnesium deficiency and to manage conditions such as eclampsia, pre‑eclampsia, and certain cardiac arrhythmias. Magnesium ions serve as cofactors for numerous enzymatic reactions, help stabilize cell membranes, and antagonize calcium‑mediated excitatory processes.

GNH India supplies Magnesiumsulfaat Kalceks as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals worldwide.

Manufacturer / TM Owner

Kalceks

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Indications & Clinical Uses

Magnesium sulfate is used in electrolyte replacement and obstetric/cardiac care to restore magnesium balance.

  • Hypomagnesemia: restores serum magnesium levels and prevents neuromuscular irritability.
  • Eclampsia: reduces seizure activity by stabilizing neuronal excitability.
  • Pre‑eclampsia: helps control blood pressure and prevents progression to eclampsia.
  • Torsades de pointes: shortens QT interval and terminates ventricular tachycardia.
  • Cardiac arrhythmias: stabilizes cardiac electrical activity and reduces ectopic beats.

How It Works

  • Magnesium sulfate dissociates to release magnesium ions that act as essential cofactors for ATP‑dependent enzymes, modulate calcium influx through voltage‑gated channels, and stabilize phospholipid membranes. By competing with calcium, it diminishes excitatory neurotransmission and smooth‑muscle contraction, leading to vasodilation, reduced neuromuscular transmission, and anti‑arrhythmic effects. These actions collectively correct magnesium deficiency and mitigate hyperexcitability in obstetric and cardiac settings.

Side Effects

Adverse reactions may occur with magnesium sulfate administration.

Common Side Effects

  • Flushing or feeling of warmth.
  • Sweating.
  • Nausea or vomiting.
  • Headache.
  • Hypotension.
  • Transient facial tingling.

Serious or Rare Side Effects

  • Respiratory depression or arrest.
  • Cardiac arrest due to severe hypermagnesemia.
  • Severe hypotension leading to shock.
  • Arrhythmias such as bradycardia.
  • Neuromuscular blockade causing paralysis.
  • Allergic reactions including rash or anaphylaxis.

Precautions & Warnings

Magnesium sulfate should be administered with careful monitoring of clinical status.

  • Renal impairment: monitor serum magnesium and adjust dose to avoid accumulation.
  • Cardiac disease: observe heart rate and rhythm continuously during infusion.
  • Neuromuscular disorders: use cautiously as it may exacerbate weakness.
  • Concomitant calcium channel blockers: watch for additive hypotensive effects.
  • Pregnancy: consider maternal‑fetal monitoring when used for eclampsia.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze.

Avoid Interactions

Magnesium sulfate can interact with several medications, requiring vigilance.

Major Interactions (Avoid)

  • Calcium channel blockers: may cause additive hypotension.
  • Neuromuscular blocking agents: can potentiate muscle relaxation and respiratory depression.
  • Other magnesium‑containing products: increase risk of hypermagnesemia.

Moderate Interactions (Monitor Closely)

  • Aminoglycoside antibiotics: may enhance neuromuscular blockade.
  • Loop diuretics: can increase renal magnesium loss, affecting therapeutic levels.

Frequently Asked Questions

Magnesiumsulfaat Kalceks is prescribed to treat low blood magnesium (hypomagnesemia), to prevent and manage seizures in eclampsia and pre‑eclampsia, and to stabilize cardiac rhythm in certain arrhythmias such as torsades de pointes. It is also used in obstetric care to protect both mother and fetus during severe hypertension.

Magnesium sulfate releases magnesium ions that serve as cofactors for many enzymatic reactions, help regulate calcium entry into cells, and stabilize cell membranes. By competing with calcium, it reduces neuronal excitability, relaxes smooth muscle, and modulates cardiac electrical activity, which together correct magnesium deficiency and prevent hyperexcitability.

The dosage of Magnesiumsulfaat Kalceks is determined by the prescribing clinician based on the patient’s condition, weight, renal function, and serum magnesium levels. The prescriber will select the appropriate concentration, route (intravenous, intramuscular, or subcutaneous), and infusion rate to achieve therapeutic goals while avoiding toxicity.

Magnesium sulfate is commonly used in pregnancy, especially for eclampsia and pre‑eclampsia, because it crosses the placenta and can protect the fetus. However, its use should be guided by a healthcare professional who will monitor maternal and fetal status. Limited data are available for breastfeeding, so a clinician should assess risk versus benefit.

To order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, and will request trade or institutional credentials. The sales team then provides pricing, availability, shipping details (including cold‑chain if needed), and assists with import documentation.

Magnesiumsulfaat Kalceks is a sterile injectable form of magnesium sulfate, offering rapid bioavailability for acute correction of magnesium deficiency and obstetric emergencies. Oral magnesium salts, such as magnesium oxide, are slower to act and are typically used for chronic supplementation. The injectable route allows precise dosing and immediate therapeutic effect, which oral forms cannot provide.

The product should be stored at 2‑8 °C in a refrigerator, protected from light, and must not be frozen or shaken vigorously. Keep the vial in its original packaging until use, and discard any solution that appears discolored or contains particles. Follow local regulations for handling injectable medicines.

Magnesiumsulfaat Kalceks is administered by a healthcare professional via intramuscular, intravenous, or subcutaneous injection. The route and infusion rate are selected based on the clinical indication, patient’s condition, and monitoring requirements. Continuous cardiac and blood pressure monitoring is recommended during intravenous administration, especially in high‑risk patients.

Serious risks include severe hypermagnesemia leading to respiratory depression, cardiac arrest, profound hypotension, and neuromuscular blockade causing paralysis. These events are more likely in patients with renal failure, excessive dosing, or when combined with other magnesium‑containing products. Prompt recognition and supportive measures are essential to mitigate these risks.

Magnesiumsulfaat Kalceks should be avoided in patients with known hypersensitivity to magnesium sulfate, severe renal impairment without appropriate monitoring, and in those with existing heart block or severe hypotension unless benefits outweigh risks. Clinicians must evaluate each patient’s medical history before initiating therapy.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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