Product image of Magnesiumsulfat B. Braun (Magnesium Sulfate Heptahydrate) supplied by GNH India

Magnesiumsulfat B. Braun

Active Ingredient:
Magnesium Sulfate Heptahydrate
Origin:
EU

Magnesiumsulfat B. Braun (Magnesium Sulfate Heptahydrate)

Magnesium sulfate, the active ingredient in Magnesiumsulfat B. Braun, is an electrolyte/mineral supplement presented as a sterile solution for intramuscular and intravenous use. It is employed to replace magnesium in patients with low serum levels and in specific obstetric and cardiac emergencies.
GNH India supplies Magnesiumsulfat B. Braun as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals worldwide.

Manufacturer / TM Owner

B.Braun Melsungen Ag

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Indications & Clinical Uses

Magnesium sulfate acts as a magnesium replacement therapy for conditions associated with low magnesium or excessive calcium activity.

  • Hypomagnesemia: restores serum magnesium concentrations and reduces neuromuscular irritability.
  • Eclampsia: prevents seizures by stabilising neuronal membranes in pregnant women with severe hypertension.
  • Pre‑eclampsia: helps control blood pressure and reduces risk of progression to eclampsia.
  • Torsades de pointes: shortens QT interval and lowers the risk of ventricular arrhythmias.
  • Severe asthma exacerbations: promotes bronchodilation and improves response to other therapies.

How It Works

  • Magnesium sulfate dissociates to release Mg2+ ions that serve as cofactors for many enzymatic reactions, compete with calcium at voltage‑gated channels, stabilize cell membranes, and induce smooth‑muscle relaxation. The resulting vasodilation, neuromuscular blockade, and anti‑arrhythmic effects underlie its therapeutic actions in electrolyte deficiency, obstetric seizures, and cardiac rhythm disturbances.

Side Effects

Adverse reactions may occur with intravenous or intramuscular administration.

Common Side Effects

  • Flushing or warmth at the injection site
  • Mild hypotension
  • Nausea or vomiting
  • Transient headache
  • Dizziness or light‑headedness

Serious or Rare Side Effects

  • Severe hypotension or shock
  • Cardiac arrest or severe arrhythmias
  • Respiratory depression
  • Hypermagnesemia with neuromuscular paralysis
  • Anaphylactic or severe allergic reactions

Precautions & Warnings

Magnesium sulfate should be used with careful clinical monitoring.

  • Renal impairment: adjust dose or avoid if severe renal failure is present.
  • Cardiac disease: monitor ECG and blood pressure continuously.
  • Neuromuscular disorders: watch for enhanced muscle weakness.
  • Pregnancy: use only when benefit outweighs potential risk to the fetus.
  • Concomitant calcium channel blockers: increase risk of hypotension and bradycardia.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Magnesium sulfate can alter the activity of several co‑administered drugs.

Major Interactions (Avoid)

  • Calcium channel blockers: additive hypotensive effect.
  • Neuromuscular blocking agents: prolonged paralysis.

Moderate Interactions (Monitor Closely)

  • Loop diuretics: may increase magnesium loss, requiring monitoring of serum levels.
  • Aminoglycoside antibiotics: risk of enhanced neuromuscular blockade.
  • Bisphosphonates: reduced absorption if given concurrently.

Frequently Asked Questions

Magnesiumsulfat B. Braun provides magnesium sulfate for the treatment of hypomagnesemia, prevention of seizures in eclampsia and pre‑eclampsia, management of torsades de pointes, and as an adjunct in severe asthma exacerbations where magnesium‑mediated bronchodilation is beneficial.

Magnesium sulfate releases magnesium ions that act as cofactors for enzymatic reactions, compete with calcium at voltage‑gated channels, stabilize neuronal membranes, cause vasodilation, and relax smooth muscle. These actions correct electrolyte deficits, reduce neuronal excitability, and help normalize cardiac rhythm.

The specific dose and infusion rate are determined by the prescribing clinician based on the patient’s condition, serum magnesium level, renal function, and clinical response. Dosing regimens are individualized and should follow the prescriber’s order.

Safety data in pregnancy are limited; the product should be used only when the expected benefit to the mother outweighs any potential risk to the fetus. Breastfeeding mothers should consult their healthcare provider, as magnesium can be excreted in breast milk.

Submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements) and necessary import documentation.

Magnesium sulfate is the most widely used injectable magnesium salt because of its high solubility and rapid bioavailability. Compared with oral magnesium oxide or gluconate, the sulfate form achieves faster serum level correction, which is essential in acute settings such as eclampsia or severe arrhythmias.

The product must be stored at 2‑8 °C in a refrigerator, protected from light. Do not freeze or shake the vial. If temperature excursions occur, discard the product according to local regulations.

Magnesiumsulfat B. Braun is supplied as a sterile solution for intramuscular or intravenous injection. Administration routes, infusion rates, and dilution volumes are determined by the treating clinician and should follow institutional protocols and the product’s prescribing information.

Serious risks include hypermagnesemia leading to respiratory depression, cardiac arrest, severe hypotension, and anaphylactic reactions. Monitoring of serum magnesium, blood pressure, respiratory status and cardiac rhythm is essential, especially in patients with renal impairment or when combined with other depressant agents.

Patients with severe renal failure, known hypersensitivity to magnesium sulfate, or those receiving high‑dose calcium channel blockers or neuromuscular blocking agents without appropriate monitoring should avoid this product unless a clinician determines that benefits outweigh risks.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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