Product image of Magnesiumsulfat Sad (Magnesium Sulfate) supplied by GNH India

Magnesiumsulfat Sad

Active Ingredient:
Magnesium Sulfate
Origin:
EU

Magnesiumsulfat Sad (Magnesium Sulfate)

Magnesium sulfate, the active ingredient in Magnesiumsulfat Sad, is a mineral salt presented as an injectable solution for intravenous use. It restores magnesium levels and is employed to treat low magnesium states and related complications such as eclampsia, pre‑eclampsia, and certain cardiac arrhythmias under medical supervision.

GNH India supplies Magnesiumsulfat Sad as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, transplant centres, oncology centres, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Amgros I/S

1
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Indications & Clinical Uses

Magnesium sulfate is administered intravenously to correct magnesium deficiency and to manage conditions where magnesium has a therapeutic role.

  • Hypomagnesemia: restores serum magnesium concentrations and alleviates neuromuscular symptoms.
  • Eclampsia: prevents seizures by stabilizing neuronal excitability.
  • Pre‑eclampsia: reduces risk of progression to eclampsia through vasodilation.
  • Torsades de pointes: shortens QT interval and terminates ventricular tachycardia.
  • Severe asthma exacerbations: promotes bronchodilation and reduces airway hyper‑responsiveness.
  • Cardiac arrhythmias: stabilizes cardiac membranes and supports rhythm control.

How It Works

  • Magnesium sulfate acts as a physiological calcium antagonist and serves as a cofactor for numerous enzymatic reactions. Intravenously, it raises extracellular magnesium, which competes with calcium at voltage‑gated channels, leading to vasodilation, reduced neuronal excitability, and stabilization of cardiac myocyte membranes, thereby correcting electrolyte imbalances and mitigating arrhythmic activity.

Side Effects

Adverse reactions may occur with intravenous magnesium administration.

Common Side Effects

  • Flushing or feeling of warmth
  • Nausea or vomiting
  • Headache
  • Mild hypotension
  • Sweating
  • Dizziness

Serious or Rare Side Effects

  • Hypermagnesemia leading to respiratory depression
  • Cardiac arrest or severe bradycardia
  • Profound hypotension
  • Arrhythmias
  • Anaphylactic reaction
  • Muscle weakness or paralysis

Precautions & Warnings

Use of magnesium sulfate requires careful assessment and monitoring.

  • Renal impairment: monitor serum magnesium and adjust infusion rate.
  • Cardiac disease: observe cardiac rhythm and blood pressure closely.
  • Electrolyte disturbances: correct potassium and calcium abnormalities before infusion.
  • Pregnancy: administer only when clearly indicated and benefits outweigh risks.
  • Concomitant medications: review for agents that may potentiate magnesium effects.
  • Store below 25°C: keep in original container, protect from moisture and direct sunlight.

Avoid Interactions

Magnesium sulfate can interact with several medications, necessitating vigilance.

Major Interactions (Avoid)

  • Calcium channel blockers: additive cardiovascular depression.
  • Neuromuscular blocking agents: potentiation of muscle relaxation.
  • Other magnesium‑containing products: risk of hypermagnesemia.

Moderate Interactions (Monitor Closely)

  • Loop diuretics: increased renal magnesium loss.
  • ACE inhibitors or ARBs: may alter potassium/magnesium balance.
  • Aminoglycoside antibiotics: potential enhancement of nephrotoxicity.

Frequently Asked Questions

Magnesiumsulfat Sad, containing magnesium sulfate, is used intravenously to treat low blood magnesium (hypomagnesemia), prevent or manage seizures in eclampsia and pre‑eclampsia, correct torsades de pointes ventricular tachycardia, aid severe asthma attacks, and stabilize cardiac arrhythmias.

Magnesium sulfate increases extracellular magnesium, which competes with calcium at voltage‑gated channels, producing vasodilation, reducing neuronal excitability, and stabilizing cardiac cell membranes. It also serves as a cofactor for many enzymes, helping restore normal physiological functions.

The specific dose and infusion rate of Magnesiumsulfat Sad are determined by the prescribing clinician based on the patient’s condition, serum magnesium level, renal function, and other clinical factors. Healthcare professionals set the appropriate regimen.

Magnesium sulfate may be used in pregnancy when the benefits outweigh potential risks, such as in eclampsia management. Its safety in breastfeeding is not fully established, so clinicians should evaluate the need and monitor the infant if treatment is continued.

To order, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements) and necessary import documentation.

Magnesiumsulfat Sad is an injectable magnesium sulfate formulation, offering rapid correction of magnesium deficits compared with oral salts that have slower absorption. It provides precise dosing for acute settings such as eclampsia or cardiac arrhythmias, whereas oral preparations are typically used for chronic supplementation.

Store the product below 25 °C in its original packaging, protecting it from moisture and direct sunlight. Ensure the vial or ampoule remains sealed until use, and follow standard aseptic techniques when preparing the intravenous solution.

Magnesiumsulfat Sad is given by intravenous infusion. The healthcare provider prepares the appropriate concentration in a compatible IV fluid and administers it over a controlled period, monitoring vital signs and serum magnesium levels throughout the infusion.

Serious risks include hypermagnesemia, which can cause respiratory depression, severe hypotension, cardiac arrest, and profound muscle weakness. Prompt monitoring of serum magnesium and clinical status is essential to detect and manage these complications early.

Patients with severe renal failure, uncontrolled heart block, or known hypersensitivity to magnesium sulfate should avoid this product. Additionally, individuals with existing hypermagnesemia or those receiving concurrent high‑dose magnesium preparations require careful evaluation before use.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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