Product image of Magrilan (Fluoxetine) supplied by GNH India

Magrilan

Active Ingredient:
Fluoxetine
Origin:
EU

Magrilan (Fluoxetine)

Fluoxetine, the active ingredient in Magrilan, is a selective serotonin reuptake inhibitor (SSRI) presented as an oral tablet for oral use. It is prescribed for several mood‑related disorders and is indicated for adult patients who require serotonergic modulation.
GNH India supplies Magrilan as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Medochemie Ltd.

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Indications & Clinical Uses

Fluoxetine acts on the serotonergic pathway and is approved for several psychiatric conditions.

  • Major depressive disorder: alleviates depressive symptoms and improves mood.
  • Obsessive‑compulsive disorder: reduces compulsive thoughts and repetitive behaviors.
  • Panic disorder: decreases frequency and intensity of panic attacks.
  • Bulimia nervosa: helps control binge‑eating and purging cycles.
  • Premenstrual dysphoric disorder: eases mood swings and physical symptoms associated with the menstrual cycle.

How It Works

  • Fluoxetine selectively inhibits the serotonin transporter (SERT) on presynaptic neurons, preventing reuptake of serotonin (5‑HT) from the synaptic cleft. This results in increased extracellular serotonin concentrations, enhancing serotonergic neurotransmission throughout the central nervous system and contributing to mood stabilization and anxiety reduction.

Side Effects

Fluoxetine may cause a range of adverse reactions that vary in frequency and severity.

Common Side Effects

  • Nausea: mild to moderate stomach upset.
  • Insomnia: difficulty falling or staying asleep.
  • Headache: transient cranial discomfort.
  • Dry mouth: reduced salivation.
  • Diarrhea: loose stools or increased bowel movements.
  • Sexual dysfunction: decreased libido or delayed orgasm.

Serious or Rare Side Effects

  • Serotonin syndrome: agitation, hyperthermia, muscle rigidity, potentially life‑threatening.
  • Suicidal thoughts: emergence of suicidal ideation, especially in young adults.
  • Hyponatremia: low blood sodium causing confusion or seizures.
  • Severe allergic reaction: rash, swelling, or difficulty breathing.

Precautions & Warnings

Before initiating fluoxetine therapy, consider the following safety measures.

  • Pregnancy: discuss potential risks with a healthcare professional, as safety data are limited.
  • Breastfeeding: evaluate benefits versus possible infant exposure through milk.
  • History of bipolar disorder: monitor for mood switching to mania or hypomania.
  • Concomitant medications: review all current drugs for possible interactions.
  • Liver or kidney impairment: dose adjustment may be required based on clinical judgment.
  • Store below 25°C: keep in the original pack, protect from moisture.

Avoid Interactions

Fluoxetine interacts with several drug classes; careful assessment is essential.

Major Interactions (Avoid)

  • Monoamine oxidase inhibitors (MAOIs): risk of serotonin syndrome if combined within 14 days.
  • Thioridazine or pimozide: can cause cardiac arrhythmias and QT prolongation.

Moderate Interactions (Monitor Closely)

  • Other serotonergic agents (e.g., tramadol, triptans): increased serotonin syndrome risk.
  • NSAIDs or anticoagulants: heightened bleeding tendency.
  • CYP2D6 inhibitors (e.g., quinidine, bupropion): may raise fluoxetine plasma levels.

Frequently Asked Questions

Magrilan, containing fluoxetine, is prescribed for major depressive disorder, obsessive‑compulsive disorder, panic disorder, bulimia nervosa, and premenstrual dysphoric disorder. It helps balance serotonin levels in the brain, which can improve mood, reduce anxiety, and control compulsive behaviors associated with these conditions.

Fluoxetine works by blocking the serotonin transporter on presynaptic nerve cells, which prevents the reabsorption of serotonin back into the neuron. This increases the amount of serotonin available in the synaptic gap, enhancing neurotransmission and contributing to mood stabilization and anxiety reduction.

The appropriate dose of Magrilan is determined by a qualified prescriber based on the patient’s specific condition, age, and response to therapy. Dosage adjustments are made according to clinical guidelines and individual tolerability, and patients should follow the prescribing physician’s instructions.

Safety data for fluoxetine during pregnancy are limited, and the drug should only be used if the potential benefits outweigh the risks. Breastfeeding mothers should discuss possible infant exposure with their healthcare provider, as fluoxetine can pass into breast milk.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and any necessary import documentation.

Magrilan (fluoxetine) belongs to the SSRI class, which generally offers a favorable side‑effect profile compared with older tricyclic antidepressants and monoamine oxidase inhibitors. It has a long half‑life, allowing once‑daily dosing, but individual response varies, and clinicians may choose alternative agents based on patient history and tolerability.

Magrilan should be stored below 25 °C in a dry place, kept in its original packaging to protect from moisture and light. Do not store in bathrooms or near heat sources, and keep the product out of reach of children.

Magrilan is taken orally, usually once daily with or without food, as directed by the prescribing clinician. Tablets should be swallowed whole with water; they should not be crushed, chewed, or broken unless specifically instructed by a healthcare professional.

Serious risks include the potential for serotonin syndrome, which can cause high fever, muscle rigidity, and seizures, as well as the emergence of suicidal thoughts, especially in young adults. Other critical concerns are severe allergic reactions, hyponatremia, and cardiac arrhythmias when combined with certain medications.

Magrilan is contraindicated in individuals who have taken monoamine oxidase inhibitors within the past 14 days, those with known hypersensitivity to fluoxetine or any tablet components, and patients with a history of severe cardiac conduction abnormalities when combined with contraindicated drugs.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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