Product image of Magrilan (Fluoxetine) supplied by GNH India

Magrilan

Active Ingredient:
Fluoxetine
Origin:
EU

Magrilan (Fluoxetine)

Fluoxetine, the active ingredient in Magrilan, is a selective serotonin reuptake inhibitor (SSRI) presented as an oral dosage form for oral use. It treats major depressive disorder and related psychiatric conditions in adult patients.

GNH India supplies Magrilan as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Medochemie Ltd.

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Indications & Clinical Uses

Magrilan belongs to the SSRI class and is prescribed for several mood‑related disorders.

  • Major depressive disorder: reduces depressive symptoms and improves overall mood.
  • Obsessive‑compulsive disorder: lessens intrusive thoughts and compulsive behaviours.
  • Panic disorder: decreases frequency and intensity of panic attacks.
  • Bulimia nervosa: helps control binge‑eating and purging cycles.
  • Premenstrual dysphoric disorder: alleviates severe premenstrual mood swings.

How It Works

  • Fluoxetine selectively inhibits the serotonin transporter (SERT) on presynaptic neurons, preventing reuptake of serotonin (5‑HT) from the synaptic cleft. This increases extracellular serotonin levels, enhancing serotonergic neurotransmission throughout central nervous system pathways that regulate mood, anxiety, and appetite.

Side Effects

Common Side Effects

  • Nausea: mild to moderate stomach upset.
  • Headache: tension‑type or throbbing pain.
  • Insomnia: difficulty falling or staying asleep.
  • Dry mouth: reduced salivation.
  • Sexual dysfunction: decreased libido or delayed orgasm.
  • Sweating: increased perspiration.

Serious or Rare Side Effects

  • Serotonin syndrome: agitation, hyperthermia, muscle rigidity.
  • Suicidal thoughts: emergence of suicidal ideation, especially early in treatment.
  • Severe allergic reaction: rash, swelling, or anaphylaxis.
  • QT interval prolongation: potential cardiac arrhythmias.
  • Hyponatremia: low blood sodium, particularly in elderly patients.
  • Abnormal bleeding: increased risk when combined with anticoagulants.

Precautions & Warnings

Magrilan requires careful clinical monitoring and patient education.

  • Assess psychiatric history: watch for worsening depression or new suicidal thoughts, especially during the first weeks.
  • Avoid concurrent MAO inhibitors: maintain a minimum 14‑day washout period.
  • Use caution in hepatic impairment: liver function may affect drug clearance.
  • Monitor electrolytes: risk of hyponatremia, particularly in older adults.
  • Discuss pregnancy and lactation: evaluate risk‑benefit with prescriber.
  • Store at ambient temperature: keep below 25°C, retain original packaging, protect from moisture.

Avoid Interactions

Magrilan can interact with several medicines that affect serotonin levels or bleeding risk.

Major Interactions (Avoid)

  • MAO inhibitors: risk of serotonin syndrome.
  • Pimozide or thioridazine: may cause cardiac arrhythmias.
  • Linezolid: additive serotonergic activity.

Moderate Interactions (Monitor Closely)

  • NSAIDs or anticoagulants: increased bleeding tendency.
  • Other serotonergic agents (e.g., tramadol, triptans): potential for serotonin syndrome.
  • Carbamazepine: may reduce fluoxetine plasma concentrations.

Frequently Asked Questions

Magrilan contains fluoxetine, an SSRI antidepressant that is prescribed to treat major depressive disorder, obsessive‑compulsive disorder, panic disorder, bulimia nervosa, and premenstrual dysphoric disorder in adult patients.

Fluoxetine blocks the serotonin transporter on presynaptic nerve endings, preventing reabsorption of serotonin. This raises serotonin levels in the synaptic cleft, enhancing serotonergic signaling that helps regulate mood, anxiety, and appetite.

The appropriate dose of Magrilan is determined by the prescribing clinician based on the individual’s condition, response, and tolerability. Dosage regimens may vary and should follow the prescriber’s instructions.

Safety of fluoxetine during pregnancy or lactation has not been definitively established. Healthcare providers weigh potential benefits against risks, and patients should discuss their specific situation with a qualified prescriber before use.

To order Magrilan, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Compared with other antidepressant classes, fluoxetine has a long half‑life, which may simplify dosing and reduce withdrawal symptoms. It is generally well‑tolerated but shares common SSRI side effects. Selection depends on individual response, side‑effect profile, drug‑interaction potential and clinician preference.

Magrilan should be stored at ambient temperature, below 25 °C, in its original container to protect it from moisture and light. Keep the product out of reach of children and do not use it after the expiry date.

Magrilan is taken orally, usually once daily with or without food, as directed by the prescriber. Swallow the tablet whole with water; do not crush or split unless specifically advised by a healthcare professional.

Serious risks include the development of serotonin syndrome, emergence of suicidal thoughts or behaviors, severe allergic reactions, QT interval prolongation, hyponatremia, and abnormal bleeding, especially when combined with anticoagulants. Prompt medical attention is required if any of these occur.

Magrilan is contraindicated in patients who are currently taking monoamine oxidase inhibitors, have a known hypersensitivity to fluoxetine or any excipients, or have a history of severe cardiac arrhythmias related to QT prolongation. Caution is also advised for individuals with uncontrolled liver disease.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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