Product image of Magurol (Doxazosin) supplied by GNH India

Magurol

Active Ingredient:
Doxazosin
Origin:
EU

Magurol (Doxazosin)

Doxazosin, the active ingredient in Magurol, is an alpha‑1 adrenergic blocker presented as a tablet for oral use. It is prescribed to lower high blood pressure and to relieve urinary obstruction caused by an enlarged prostate in adult patients.

GNH India supplies Magurol as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, ensuring quality and regulatory compliance across global markets and providing reliable logistics for timely delivery.

Manufacturer / TM Owner

Medochemie Ltd.

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Indications & Clinical Uses

Doxazosin is used in conditions that involve alpha‑1 receptor‑mediated vascular tone or smooth‑muscle contraction.

  • Hypertension: reduces systolic and diastolic blood pressure by causing vasodilation.
  • Benign prostatic hyperplasia (BPH): improves urinary flow by relaxing smooth muscle in the prostate and bladder neck.
  • Peripheral vascular resistance reduction: assists in overall management of elevated blood pressure.

How It Works

  • Doxazosin selectively antagonizes alpha‑1 adrenergic receptors on vascular smooth muscle and in the prostate. Blocking these receptors prevents norepinephrine‑induced vasoconstriction, leading to vasodilation and lowered peripheral vascular resistance. In the urinary tract, the same antagonism relaxes smooth muscle of the prostate and bladder neck, facilitating urine flow.

Side Effects

Common side effects are generally mild and may resolve with continued therapy.

Common Side Effects

  • Dizziness or light‑headedness
  • Headache
  • Fatigue or weakness
  • Nasal congestion
  • Peripheral edema
  • Nausea or abdominal discomfort

Serious or Rare Side Effects

  • Severe hypotension or syncope
  • Acute heart failure exacerbation
  • Priapism (prolonged erection)
  • Sudden severe liver injury (rare)
  • Allergic reactions such as rash or angioedema

Precautions & Warnings

Before initiating therapy, consider the following safety measures.

  • Blood pressure monitoring: check baseline and periodic readings.
  • Renal function assessment: adjust use in significant impairment.
  • Hepatic impairment: use with caution and monitor liver enzymes.
  • Concomitant antihypertensives: avoid excessive blood pressure drop.
  • Discontinuation: taper rather than abrupt stop to prevent rebound hypertension.
  • Store at room temperature: keep in the original container, protect from moisture and direct sunlight.

Avoid Interactions

Doxazosin may interact with several drug classes; awareness helps prevent adverse events.

Major Interactions (Avoid)

  • Other alpha‑blockers (e.g., prazosin, terazosin): additive hypotensive effect.
  • Strong CYP3A4 inhibitors (e.g., ketoconazole, itraconazole): increased plasma concentrations.
  • Phosphodiesterase‑5 inhibitors (e.g., sildenafil, tadalafil): risk of severe hypotension.

Moderate Interactions (Monitor Closely):\n- Diuretics: may enhance orthostatic hypotension.

  • ACE inhibitors or ARBs: additive blood pressure lowering.
  • NSAIDs: may blunt antihypertensive response.
  • Calcium channel blockers: possible increased effect on blood pressure.
  • Tricyclic antidepressants: may potentiate hypotensive episodes.

Frequently Asked Questions

Magurol contains doxazosin, which is prescribed to treat high blood pressure (hypertension) and to alleviate urinary symptoms caused by an enlarged prostate (benign prostatic hyperplasia). It works by relaxing blood vessels and prostate smooth muscle, helping to lower blood pressure and improve urine flow.

Doxazosin selectively blocks alpha‑1 adrenergic receptors on vascular smooth muscle and in the prostate. This blockade prevents norepinephrine‑induced constriction, causing blood vessels to dilate and reducing peripheral resistance. In the prostate, it relaxes smooth muscle, easing urinary obstruction.

The appropriate dose of Magurol is determined by the prescribing clinician based on the patient’s medical condition, response to therapy, and any other medications being taken. Dosage adjustments are individualized and should follow the prescriber’s instructions.

Safety data for doxazosin in pregnancy and lactation are limited. It should only be used if the potential benefit justifies any possible risk to the fetus or infant. Women who are pregnant, planning pregnancy, or breastfeeding should discuss alternatives with their healthcare provider.

To request Magurol, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Magurol (doxazosin) belongs to the alpha‑1 blocker class, which differs from ACE inhibitors, ARBs, beta‑blockers, and calcium channel blockers in its mechanism of action. It is particularly useful when a patient also has benign prostatic hyperplasia, offering dual benefits that many other antihypertensives do not provide.

Magurol tablets should be stored at room temperature, below 25 °C, in the original packaging to protect them from moisture and light. Keep the container tightly closed and out of reach of children.

Magurol is taken orally, usually with a glass of water. It can be taken with or without food, but patients should follow the prescribing clinician’s guidance on timing and whether to take it at the same time each day.

The most serious risks include severe hypotension, syncope, and rare cases of priapism or acute heart‑failure exacerbation. Patients should report sudden dizziness, fainting, chest pain, or prolonged erections to a healthcare professional immediately.

Magurol should be avoided in patients with known hypersensitivity to doxazosin or any component of the formulation, in those with severe hepatic impairment, and in individuals taking other potent alpha‑blockers without close medical supervision. Contraindications are confirmed by the prescribing clinician.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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