Product image of Magurol (Doxazosin) supplied by GNH India

Magurol

Active Ingredient:
Doxazosin
Origin:
EU

Magurol (Doxazosin)

Doxazosin, the active ingredient in Magurol, is a Alpha-1 adrenergic blocker presented as an oral dosage form for oral use. It is indicated for the management of hypertension and for relief of urinary symptoms caused by benign prostatic hyperplasia in adult patients.

GNH India supplies Magurol as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Medochemie Ltd.

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Indications & Clinical Uses

Doxazosin belongs to the alpha‑1 adrenergic blocker class and is used to treat conditions related to vascular tone and prostatic enlargement.

  • Hypertension: lowers systemic blood pressure by relaxing peripheral arterial smooth muscle.
  • Benign prostatic hyperplasia (BPH): improves urinary flow by reducing smooth‑muscle tone in the prostate and bladder neck.
  • Lower urinary tract symptoms due to BPH: decreases urgency, frequency and nocturia associated with prostatic enlargement.

How It Works

  • Doxazosin selectively antagonizes peripheral alpha‑1 adrenergic receptors on vascular smooth muscle and prostatic tissue. By blocking these receptors, it prevents norepinephrine‑mediated vasoconstriction, leading to vasodilation and reduced peripheral vascular resistance, while also relaxing smooth muscle in the prostate and bladder neck to ease urinary obstruction.

Side Effects

Adverse reactions may vary in frequency and severity.

Common Side Effects

  • Dizziness or light‑headedness, especially on standing.
  • Headache.
  • Fatigue or generalized weakness.
  • Nasal congestion or rhinorrhea.
  • Peripheral edema.

Serious or Rare Side Effects

  • Severe hypotension or syncope.
  • Tachycardia or arrhythmia.
  • Allergic reactions such as rash, pruritus or angioedema.
  • Liver function abnormalities.
  • Priapism (rare).

Precautions & Warnings

Before initiating therapy, clinicians should evaluate patient‑specific factors and monitor for potential risks.

  • Blood pressure monitoring: check orthostatic readings after the first dose.
  • Renal or hepatic impairment: adjust therapy based on organ function.
  • Concomitant antihypertensives: assess for additive hypotensive effect.
  • Pregnancy and lactation: safety not established; avoid unless clearly needed.
  • Discontinuation: taper gradually to prevent rebound hypertension.
  • Store at room temperature: keep in the original container, protect from moisture and direct sunlight.

Avoid Interactions

Doxazosin may interact with several drug classes, altering its efficacy or safety profile.

Major Interactions (Avoid)

  • Other potent antihypertensives (e.g., ACE inhibitors, ARBs) – risk of excessive blood pressure drop.
  • Potassium‑sparing diuretics – may enhance hypotensive effect.
  • Strong CYP3A4 inhibitors (e.g., ketoconazole) – increase plasma concentrations.

Moderate Interactions (Monitor Closely):\n- Non‑steroidal anti‑inflammatory drugs (NSAIDs) – may blunt antihypertensive response.

  • Beta‑blockers – combined effect on heart rate and blood pressure.
  • Alcohol – can potentiate dizziness and hypotension.

Frequently Asked Questions

Magurol contains doxazosin, which is prescribed to lower high blood pressure (essential hypertension) and to relieve urinary symptoms caused by benign prostatic hyperplasia, such as difficulty starting urination, weak stream, and frequent nighttime urination.

Doxazosin blocks alpha‑1 adrenergic receptors on blood vessels and prostatic smooth muscle. This inhibition prevents norepinephrine‑induced constriction, leading to vessel dilation and reduced peripheral resistance, while also relaxing the prostate and bladder neck to improve urine flow.

The appropriate dose of Magurol is determined by the prescribing clinician based on the individual’s medical condition, response to therapy, and any concomitant medications. Patients should follow the prescriber’s instructions and not adjust the dose on their own.

Safety of doxazosin in pregnancy and lactation has not been established. It should only be used if the potential benefit justifies the potential risk to the fetus or infant, and this decision must be made by a qualified healthcare professional.

To request Magurol, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Compared with non‑selective alpha blockers, doxazosin offers more targeted alpha‑1 antagonism, resulting in fewer reflex tachycardia events. It is often chosen for patients who also need relief of BPH symptoms, whereas other classes such as ACE inhibitors or calcium channel blockers focus solely on blood pressure control.

Magurol should be stored at room temperature, below 25 °C, in its original packaging. Keep the product away from moisture, direct sunlight and extreme heat to maintain its stability and potency throughout its shelf life.

Magurol is taken orally, usually with or without food, as directed by the prescriber. The tablet should be swallowed whole with a glass of water and not chewed or crushed unless specifically instructed by a healthcare professional.

The most serious risks include severe hypotension leading to fainting, rapid heart rate or arrhythmias, and rare allergic reactions such as rash, swelling or anaphylaxis. Patients should seek immediate medical attention if they experience these symptoms.

Magurol is contraindicated in patients with known hypersensitivity to doxazosin or any component of the formulation, and it should be used with caution in individuals with severe liver disease, uncontrolled heart failure, or those taking interacting medications that could cause dangerous blood‑pressure drops.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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