Product image of Makiren (Mometasone Furoate) supplied by GNH India

Makiren

Active Ingredient:
Mometasone Furoate
Origin:
EU

Makiren (Mometasone Furoate)

Mometasone furoate, the active ingredient in Makiren, is a corticosteroid presented as a topical formulation for skin use. It is prescribed to manage inflammatory dermatoses such as atopic dermatitis, psoriasis and contact dermatitis in patients requiring anti‑inflammatory therapy. Its high potency allows effective symptom control with once‑daily application in many cases.

GNH India supplies Makiren as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to stringent quality standards and provides reliable sourcing for regulated markets.

Manufacturer / TM Owner

Rafarm Sa.

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Indications & Clinical Uses

  • Mometasone furoate is a topical corticosteroid that reduces inflammation in various skin disorders.
  • Atopic dermatitis: reduces redness, scaling and itching associated with the condition.
  • Psoriasis: decreases plaque formation and inflammation.
  • Contact dermatitis: alleviates irritation caused by allergic or irritant exposures.
  • Other inflammatory skin conditions: provides symptomatic relief in conditions such as seborrheic dermatitis or lichen planus.

How It Works

  • Mometasone furoate binds to intracellular glucocorticoid receptors, forming a complex that translocates to the nucleus and modulates gene transcription. This interaction suppresses pro‑inflammatory cytokine production, inhibits leukocyte migration, and reduces vascular permeability, resulting in potent anti‑inflammatory and immunosuppressive effects in the skin.

Side Effects

Topical application of mometasone furoate may be associated with local and systemic adverse reactions.

Common Side Effects

  • Skin burning or stinging
  • Pruritus
  • Dryness or peeling

Serious or Rare Side Effects

  • Hypothalamic‑pituitary‑adrenal axis suppression
  • Severe skin atrophy or striae
  • Secondary infection of treated area

Precautions & Warnings

  • When using Makiren, consider the following precautions to minimize risks.
  • Avoid use on infected or broken skin: consult a healthcare professional before application.
  • Limit duration of therapy: prolonged use may increase risk of skin atrophy.
  • Do not apply under occlusive dressings unless directed: may enhance systemic absorption.
  • Use the smallest effective amount: to minimize adverse effects.
  • Pregnancy and lactation: safety not established, weigh benefits against risks.
  • Store at room temperature: keep in original container, protect from moisture and light.

Avoid Interactions

Mometasone furoate may interact with other agents that affect steroid metabolism or absorption.

Major Interactions (Avoid)

  • Systemic corticosteroids: concurrent use may increase risk of systemic glucocorticoid effects.
  • Strong CYP3A4 inhibitors (e.g., ketoconazole): may raise local drug levels.

Moderate Interactions (Monitor Closely)

  • Topical antifungal agents applied to same area: may alter absorption.
  • Occlusive dressings: increase percutaneous absorption, monitor for side effects.
  • Other topical steroids: additive potency, adjust treatment accordingly.

Frequently Asked Questions

Makiren contains mometasone furoate and is indicated for the topical treatment of inflammatory skin disorders such as atopic dermatitis, psoriasis, contact dermatitis and other similar conditions where reduction of redness, scaling and itching is desired.

Mometasone furoate binds to glucocorticoid receptors inside skin cells, altering gene transcription. This suppresses the production of inflammatory mediators, reduces leukocyte migration, and limits vascular leakage, providing a potent anti‑inflammatory and immunosuppressive effect on the skin.

The appropriate dose of Makiren is determined by the prescribing healthcare professional based on the severity of the skin condition, the area to be treated and patient‑specific factors. No fixed regimen is provided here; the prescriber sets the regimen.

Safety data for mometasone furoate in pregnancy and lactation are limited. The product should only be used if the potential benefit justifies any potential risk to the fetus or infant, and the decision should be made in consultation with a qualified healthcare provider.

To request Makiren, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Mometasone furoate is a high‑potency corticosteroid, offering stronger anti‑inflammatory activity than low‑potency agents such as hydrocortisone. Compared with other high‑potency steroids like clobetasol, it provides similar efficacy with a slightly lower risk of systemic absorption when used as directed.

Makiren should be stored at room temperature, below 25 °C, in its original packaging. Keep the container tightly closed, protect it from moisture and direct sunlight, and keep it out of reach of children.

Apply a thin layer of Makiren to the affected skin area once daily or as directed by a healthcare professional. Gently rub the product until it disappears, avoid contact with eyes, and wash hands after application unless the hands are the treatment site.

Serious risks include hypothalamic‑pituitary‑adrenal (HPA) axis suppression, severe skin atrophy or striae, and secondary bacterial, fungal or viral infections of the treated area. These events are uncommon but require prompt medical evaluation if they occur.

Makiren should be avoided in individuals with known hypersensitivity to mometasone furoate or any formulation excipients, in patients with untreated skin infections, and in those for whom systemic corticosteroid therapy is contraindicated unless specifically advised by a physician.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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