Product image of Makro-Albumon (Human Serum Albumin) supplied by GNH India

Makro-Albumon

Active Ingredient:
Human Serum Albumin
Origin:
EU

Makro-Albumon (Human Serum Albumin)

Human Serum Albumin, the active ingredient in Makro-Albumon, is a plasma volume expander presented as a sterile injectable solution for intravenous use. It is employed to increase circulating plasma volume in patients with hypovolemia, severe burns, hypoalbuminemia, and other conditions requiring rapid oncotic support.

GNH India supplies Makro-Albumon as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, transplant centres and clinics worldwide.

Manufacturer / TM Owner

Medi-Radiopharma Kft.

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Indications & Clinical Uses

Makro-Albumon is a human serum albumin product used in clinical situations that require rapid plasma volume expansion and restoration of oncotic pressure.

  • Hypovolemia: restores intravascular volume and improves tissue perfusion.
  • Severe burns: supports plasma oncotic pressure and reduces edema.
  • Hypoalbuminemia: raises serum albumin concentrations to normal levels.
  • Cardiac surgery: maintains hemodynamic stability during peri‑operative fluid management.

How It Works

  • Human Serum Albumin increases plasma oncotic pressure by providing a high‑molecular‑weight colloid that retains water within the vascular compartment. This osmotic effect expands intravascular volume, improves circulatory stability, and facilitates transport of endogenous substances such as fatty acids, hormones, and drugs throughout the bloodstream.

Side Effects

Human Serum Albumin may be associated with a range of adverse reactions, most of which are related to infusion or immune response.

Common Side Effects

  • Fever or chills during infusion.
  • Mild rash or urticaria.
  • Transient hypotension.
  • Headache.
  • Nausea or vomiting.
  • Localized pain at the injection site.

Serious or Rare Side Effects

  • Anaphylactic or severe allergic reaction.
  • Volume overload leading to pulmonary edema.
  • Acute renal failure.
  • Hemolysis.
  • Thrombosis or embolic events.
  • Severe hypertension.

Precautions & Warnings

When using Makro-Albumon, clinicians should observe several safety measures to minimize risk.

  • Assess fluid status: avoid excessive volume that could cause overload.
  • Monitor serum albumin levels: adjust dosing based on laboratory results.
  • Check for allergy: discontinue immediately if signs of hypersensitivity appear.
  • Use caution in cardiac failure: patients are prone to volume‑related complications.
  • Avoid in patients with known hypersensitivity to human albumin preparations.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Human Serum Albumin can interact with other agents that affect fluid balance or coagulation.

Major Interactions (Avoid)

  • Concurrent high‑dose diuretics: may worsen intravascular depletion.
  • Vasopressor therapy: can mask hypotensive responses.
  • Incompatible plasma products: risk of immune reactions.

Moderate Interactions (Monitor Closely)

  • Synthetic colloids (e.g., hydroxyethyl starch): additive volume effect.
  • Renal replacement therapy: may alter albumin clearance.
  • Anticoagulants: monitor for altered bleeding risk.

Frequently Asked Questions

Makro-Albumon is a sterile human serum albumin solution used as a plasma volume expander. It helps restore intravascular volume and oncotic pressure in patients with hypovolemia, severe burns, hypoalbuminemia, or during major surgery where rapid fluid support is required.

Human Serum Albumin acts as a high‑molecular‑weight colloid that raises plasma oncotic pressure. By retaining water within the vascular space, it expands circulating blood volume, improves tissue perfusion, and serves as a carrier for fatty acids, hormones, and certain drugs.

The dose of Makro-Albumon is individualized. The prescribing clinician determines the amount and infusion rate based on the patient’s clinical condition, fluid status, and target serum albumin level. No standard dosing regimen is provided in public literature.

Human Serum Albumin is classified as pregnancy category unknown. Limited data exist, so the product should only be used when the potential benefit to the mother outweighs any possible risk to the fetus or infant. Breastfeeding considerations follow the same risk‑benefit assessment.

To order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain if needed), and import documentation.

Makro-Albumon (human albumin) is a natural protein‑based colloid, whereas synthetic options such as hydroxyethyl starch or gelatin are polymeric. Albumin generally has a lower risk of coagulopathy and renal injury, but it is more expensive and requires refrigerated storage.

Makro-Albumon must be stored at 2‑8 °C, protected from light, and kept in its original container. It should not be frozen or shaken vigorously, as this can cause protein denaturation and reduce product efficacy.

The product is given by intravenous infusion. Administration rate is determined by the prescriber, often starting with a slow initial infusion to assess tolerance, followed by adjustment based on the patient’s hemodynamic response and target plasma albumin level.

Serious risks include anaphylactic reactions, volume overload leading to pulmonary edema, and rare events such as hemolysis or thrombosis. Prompt recognition and immediate discontinuation of the infusion are essential if these events occur.

Makro-Albumon is contraindicated in patients with known hypersensitivity to human serum albumin, severe congestive heart failure, uncontrolled pulmonary edema, or those in whom volume overload would pose a significant risk.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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