Product image of Makro-Albumon (Human Albumin As Macroaggregates) supplied by GNH India

Makro-Albumon

Active Ingredient:
Human Albumin As Macroaggregates
Origin:
EU

Makro-Albumon (Human Albumin As Macroaggregates)

Human Albumin Macroaggregates, the active ingredient in Makro-Albumon, is an albumin drug presented as an injectable formulation for intravenous use. It is employed primarily in diagnostic imaging to assess pulmonary perfusion and related conditions.
GNH India supplies Makro-Albumon as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, transplant centres, oncology centres, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Medi-Radiopharma Kft.

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Indications & Clinical Uses

Makro-Albumon is used in nuclear medicine procedures that evaluate pulmonary blood flow and related disorders.

  • Lung perfusion imaging: enables visualization of regional pulmonary blood flow for diagnostic assessment.
  • Pulmonary embolism detection: assists in identifying embolic obstruction of pulmonary arteries.
  • Pre‑operative lung function evaluation: provides functional information to guide surgical planning.

How It Works

  • Human Albumin Macroaggregates consist of sterile, calibrated particles that, when injected intravenously, become temporarily lodged in the pulmonary capillary bed. The particles act as carriers for a radiotracer, allowing gamma cameras to map perfusion distribution within the lungs and detect areas of reduced blood flow or obstruction.

Side Effects

Makro-Albumon may be associated with a range of adverse reactions following intravenous administration.

Common Side Effects

  • Transient fever: mild temperature rise shortly after injection.
  • Mild hypotension: temporary drop in blood pressure.
  • Headache: short‑lasting discomfort.
  • Nausea: occasional feeling of queasiness.
  • Injection site discomfort: mild pain or irritation.
  • Flushing: brief redness of skin.

Serious or Rare Side Effects

  • Anaphylactic reaction: severe allergic response requiring immediate medical attention.
  • Severe hypotension: marked blood pressure decline with possible syncope.
  • Pulmonary hypertension: abrupt increase in pulmonary arterial pressure.
  • Embolic complications: rare lodging of particles causing vascular blockage.
  • Acute respiratory distress: sudden breathing difficulty.
  • Cardiovascular collapse: life‑threatening circulatory failure.

Precautions & Warnings

Prior to using Makro-Albumon, clinicians should consider several safety measures.

  • Allergy assessment: verify no known hypersensitivity to human albumin or related proteins.
  • Cardiac evaluation: avoid in patients with severe heart failure or uncontrolled hypertension.
  • Pulmonary status: contraindicated in severe pulmonary hypertension or acute respiratory distress.
  • Volume monitoring: watch for signs of fluid overload, especially when combined with other albumin products.
  • Concurrent radiopharmaceuticals: ensure appropriate timing to prevent imaging interference.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake the vial.

Avoid Interactions

Makro-Albumon may interact with other agents administered intravenously.

Major Interactions (Avoid)

  • Other intravenous albumin solutions: risk of volume overload and circulatory strain.
  • High‑dose diuretics: may exacerbate hypotension.

Moderate Interactions (Monitor Closely)

  • Anticoagulants (e.g., heparin, warfarin): potential alteration of bleeding risk.
  • Beta‑blockers: additive effect on blood pressure reduction.
  • Vasodilators (e.g., nitroglycerin): increased likelihood of hypotensive episodes.
  • Radiopharmaceuticals with overlapping emission spectra: may affect imaging interpretation.

Frequently Asked Questions

Makro-Albumon is a sterile injectable containing human albumin macroaggregates that is used in nuclear medicine to perform lung perfusion scans. The procedure helps visualize blood flow in the pulmonary circulation, aiding in the diagnosis of pulmonary embolism, assessment of lung function before surgery, and evaluation of other pulmonary vascular conditions.

The macroaggregated albumin particles are calibrated to a specific size range that allows them to become temporarily trapped in the small vessels of the lungs after intravenous injection. When labeled with a radiotracer, these particles emit gamma radiation that can be detected by a gamma camera, producing a detailed map of pulmonary perfusion.

The dose of Makro-Albumon is determined by the prescribing physician based on the specific imaging protocol, patient weight, and clinical indication. Healthcare professionals calculate the appropriate activity of the radiolabeled preparation and the volume of macroaggregated albumin to administer for each individual case.

Safety data for Makro-Albumon in pregnant or breastfeeding individuals are limited. Because the product involves a radiopharmaceutical component, it is generally avoided unless the diagnostic benefit outweighs potential risks. Clinicians should discuss any concerns with the patient and consider alternative imaging methods when appropriate.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies, and procurement teams worldwide. After receiving the request, the sales team will verify trade or institutional credentials, then provide pricing, availability, shipping details (including cold‑chain logistics if needed), and any required import documentation.

Makro-Albumon uses human albumin macroaggregates as the carrier for the radiotracer, offering a well‑characterized particle size distribution that provides reliable capillary lodging. Compared with alternative agents such as technetium‑99m labeled macroaggregated albumin from other manufacturers, Makro-Albumon meets EU quality standards and is supplied with consistent sterility and particle uniformity, which can improve imaging reproducibility.

Makro-Albumon must be stored refrigerated at 2‑8 °C. The vials should be kept in their original packaging, protected from light, and must not be frozen or shaken. Prior to administration, allow the product to reach room temperature if required by the imaging protocol, and inspect for any particulate matter or discoloration.

Makro-Albumon is administered intravenously by a qualified healthcare professional. The prepared radiolabeled suspension is injected slowly, typically through a peripheral vein, while the patient is monitored for vital signs. The injection is followed by imaging with a gamma camera to capture the distribution of the radiotracer within the lungs.

The most serious risks include severe allergic reactions such as anaphylaxis, marked hypotension, and rare embolic events that can compromise pulmonary circulation. Patients should be observed closely during and after injection, and emergency measures must be readily available to manage any acute adverse reactions.

Makro-Albumon is contraindicated in individuals with known hypersensitivity to human albumin or any component of the formulation, patients with severe pulmonary hypertension, uncontrolled heart failure, or those who have experienced a severe reaction to a previous macroaggregated albumin scan. Clinicians should evaluate each patient’s medical history before administration.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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