Product image of Malditesta (Paracetamol, Metoclopramide Hydrochloride Monohydrate) supplied by GNH India

Malditesta

Active Ingredient:
Paracetamol, Metoclopramide Hydrochloride Monohydrate
Origin:
EU

Malditesta (Paracetamol, Metoclopramide Hydrochloride Monohydrate)

Paracetamol and Metoclopramide Hydrochloride Monohydrate, the active ingredients in Malditesta, are an analgesic and antiemetic combination presented as an oral tablet for oral use. The product is indicated for relief of mild to moderate pain, fever, and for prevention or treatment of nausea and vomiting in postoperative or chemotherapy settings.
GNH India supplies Malditesta as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Verisfield S.M.S.A

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Indications & Clinical Uses

Malditesta acts on pain pathways and the central chemoreceptor trigger zone to provide relief in several clinical situations.

  • Mild to moderate pain and fever: provides analgesic and antipyretic relief.
  • Postoperative nausea and vomiting: prevents and treats nausea after surgery.
  • Chemotherapy‑induced nausea and vomiting: reduces nausea associated with cancer treatment.

How It Works

  • Paracetamol exerts its analgesic and antipyretic effects by centrally inhibiting cyclo‑oxygenase enzymes and decreasing prostaglandin synthesis. Metoclopramide hydrochloride monohydrate is a dopamine D2‑receptor antagonist that enhances gastrointestinal motility and blocks the central chemoreceptor trigger zone, thereby producing antiemetic activity.

Side Effects

Adverse reactions may occur with Malditesta and should be monitored.

Common Side Effects

  • Drowsiness: mild sedation or sleepiness.
  • Dizziness: sensation of light‑headedness.
  • Headache: transient cranial pain.
  • Dry mouth: reduced salivation.
  • Constipation: slowed bowel movements.

Serious or Rare Side Effects

  • Extrapyramidal symptoms: involuntary muscle movements or rigidity.
  • Neuroleptic malignant syndrome: rare but life‑threatening reaction.
  • Severe allergic reaction: rash, swelling, or anaphylaxis.

Precautions & Warnings

Before prescribing Malditesta, consider the following precautions.

  • Pregnancy: consult a healthcare provider before use.
  • Breastfeeding: assess risk versus benefit for the infant.
  • Elderly patients: monitor for increased sedation and extrapyramidal effects.
  • Renal or hepatic impairment: dose adjustment may be required.
  • Concomitant CNS depressants: may enhance sedative effects.
  • Store at ambient temperature: keep in the original container, protect from moisture.

Avoid Interactions

Malditesta may interact with other medicines; awareness of major and moderate interactions is important.

Major Interactions (Avoid)

  • Antipsychotics (e.g., haloperidol): increased risk of extrapyramidal reactions.
  • MAO inhibitors: potential hypertensive crisis when combined with metoclopramide.
  • CYP450 inducers (e.g., rifampicin): may reduce paracetamol efficacy.

Moderate Interactions (Monitor Closely)

  • Opioids: additive central nervous system depression.
  • Anticholinergics: may diminish metoclopramide’s pro‑kinetic effect.
  • Warfarin: paracetamol can enhance anticoagulant activity, requiring INR monitoring.

Frequently Asked Questions

Malditesta is a prescription oral tablet that combines paracetamol and metoclopramide to relieve mild to moderate pain and fever, and to prevent or treat nausea and vomiting associated with surgery, chemotherapy, or other causes.

Paracetamol acts centrally by inhibiting cyclo‑oxygenase enzymes, which reduces prostaglandin synthesis. This leads to decreased pain perception and a lowering of body temperature, providing analgesic and antipyretic effects.

The appropriate dose of Malditesta is determined by the prescribing healthcare professional based on the patient’s condition, age, weight, and other clinical factors. Patients should follow the prescriber’s instructions exactly.

Safety in pregnancy and lactation has not been fully established. Healthcare providers should evaluate the potential benefits against any possible risks before prescribing Malditesta to pregnant or nursing women.

To order Malditesta, submit an enquiry on the product page at gnhindia.com indicating the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Malditesta offers a fixed‑dose combination of an analgesic (paracetamol) and an antiemetic (metoclopramide), which can simplify therapy compared with taking two separate medications. It is useful when both pain/fever and nausea need simultaneous control, whereas single‑agent products address only one of those symptoms.

Store Malditesta tablets at ambient temperature, preferably below 25 °C. Keep them in the original packaging, protect from moisture and direct sunlight, and keep out of reach of children.

Malditesta is taken orally, usually with a glass of water. It may be taken with or without food, but patients should follow the specific instructions provided by their prescriber.

Serious risks include extrapyramidal symptoms such as dystonia or akathisia, neuroleptic malignant syndrome, and severe allergic reactions like anaphylaxis. Patients should seek immediate medical attention if they experience muscle rigidity, high fever, rash, or difficulty breathing.

Malditesta should be avoided in individuals with known hypersensitivity to paracetamol, metoclopramide, or any excipients, as well as in patients with severe hepatic impairment, uncontrolled epilepsy, or those taking contraindicated medications such as certain antipsychotics.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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