Product image of Maleato De Enalapril Mylan (Enalapril Maleate) supplied by GNH India

Maleato De Enalapril Mylan

Active Ingredient:
Enalapril Maleate
Origin:
EU

Maleato De Enalapril Mylan (Enalapril Maleate)

Enalapril, the active ingredient in Maleato De Enalapril Mylan, is an ACE inhibitor presented as an oral tablet for oral use. It is used to manage hypertension, heart failure, asymptomatic left ventricular dysfunction, and diabetic nephropathy in adult patients.

GNH India supplies Maleato De Enalapril Mylan as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, ensuring quality and regulatory compliance across global markets and supporting timely delivery to healthcare providers.

Manufacturer / TM Owner

Viatris Limited

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Indications & Clinical Uses

Enalapril, an ACE inhibitor, is indicated for several cardiovascular and renal conditions.

  • Hypertension: lowers blood pressure by reducing vascular resistance.
  • Heart failure: improves symptoms and reduces hospitalization risk.
  • Asymptomatic left ventricular dysfunction: slows disease progression.
  • Diabetic nephropathy: helps preserve kidney function in patients with diabetes.

How It Works

  • Enalapril is converted in vivo to enalaprilat, which binds to and inhibits angiotensin‑converting enzyme (ACE). This blockade prevents the conversion of angiotensin I to the potent vasoconstrictor angiotensin II, leading to vasodilation, reduced aldosterone secretion, decreased sodium and water retention, and ultimately lower blood pressure and cardiac workload.

Side Effects

Adverse reactions may range from mild to severe and should be monitored during therapy.

Common Side Effects

  • Cough: persistent dry cough in some patients.
  • Dizziness: especially after the first dose or dose increase.
  • Headache: mild to moderate intensity.
  • Fatigue: general feeling of tiredness.
  • Hypotension: especially in volume‑depleted individuals.
  • Hyperkalemia: mild elevation of serum potassium.

Serious or Rare Side Effects

  • Angioedema: swelling of face, lips, tongue, or airway.
  • Neutropenia: significant reduction in white blood cells.
  • Severe hypotension: marked drop in blood pressure causing fainting.
  • Acute renal failure: sudden loss of kidney function.
  • Hepatic dysfunction: abnormal liver enzyme elevations.

Precautions & Warnings

Before initiating therapy, clinicians should evaluate several safety considerations.

  • Monitor blood pressure: adjust dose to avoid excessive hypotension.
  • Assess renal function: check serum creatinine and eGFR regularly.
  • Check serum potassium: avoid hyperkalemia, especially with potassium‑sparing agents.
  • Pregnancy safety: contraindicated in pregnancy (Category D) due to fetal risk.
  • Store at room temperature: keep in the original pack, protect from moisture and direct sunlight.

Avoid Interactions

Enalapril may interact with other medicines, requiring careful management.

Major Interactions (Avoid)

  • Aliskiren: combined use in diabetic patients can increase renal risk.
  • Lithium: may raise lithium levels, leading to toxicity.
  • Potassium‑sparing diuretics: increase risk of hyperkalemia.

Moderate Interactions (Monitor Closely)

  • NSAIDs: can reduce antihypertensive effect and impair renal function.
  • Rifampin: may lower enalapril plasma concentrations.
  • Loop or thiazide diuretics: may cause additive hypotensive effect.

Frequently Asked Questions

Maleato De Enalapril Mylan contains enalapril, an ACE inhibitor prescribed for hypertension, chronic heart failure, asymptomatic left ventricular dysfunction, and diabetic nephropathy. It works by lowering blood pressure and reducing the workload on the heart, helping to prevent disease progression in these cardiovascular and renal disorders.

Enalapril is converted to its active form, enalaprilat, which blocks the angiotensin‑converting enzyme. This inhibition prevents the formation of angiotensin II, a powerful vasoconstrictor, leading to relaxed blood vessels, reduced aldosterone release, lower sodium and water retention, and ultimately a decrease in blood pressure and cardiac strain.

The appropriate dose of enalapril is individualized by the prescribing healthcare professional based on the patient’s condition, response, and renal function. Dosage adjustments are made according to clinical guidelines and the prescriber’s judgment; patients should follow the exact regimen provided by their doctor.

Enalapril is classified as Pregnancy Category D, indicating evidence of fetal risk and it should be avoided in pregnancy. It is also not recommended while breastfeeding because it can pass into breast milk. Women who are pregnant, planning pregnancy, or nursing should discuss alternative therapies with their physician.

To place an order, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and any necessary import documentation.

Enalapril belongs to the ACE inhibitor class, which directly blocks the renin‑angiotensin system. Compared with calcium‑channel blockers or beta‑blockers, ACE inhibitors also provide renal protection in diabetic patients and reduce proteinuria. Choice of therapy depends on patient comorbidities, tolerability, and physician preference.

Store the tablets at room temperature, below 25 °C, in the original container. Keep them away from moisture, excessive heat, and direct sunlight. Do not refrigerate or freeze the product, and ensure the packaging remains tightly closed to maintain stability.

The medication is taken orally, usually once or twice daily as directed by the prescriber. Tablets should be swallowed whole with a full glass of water and can be taken with or without food. Patients should follow the dosing schedule provided by their healthcare professional.

Serious adverse events include angioedema, which can threaten the airway, severe hypotension leading to fainting, acute kidney injury, and significant hyperkalemia. Patients should seek immediate medical attention if they experience swelling of the face or throat, sudden dizziness, or marked changes in urine output.

Enalapril is contraindicated in patients with a known hypersensitivity to the drug or any ACE inhibitors, in those with a history of angioedema related to ACE inhibitor therapy, and in pregnant women. Caution is also advised for individuals with severe renal impairment or hyperkalemia.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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