Product image of Mallebrin (Aluminium Chloride Hexahydrate) supplied by GNH India

Mallebrin

Active Ingredient:
Aluminium Chloride Hexahydrate
Origin:
EU

Mallebrin (Aluminium Chloride Hexahydrate)

Aluminium Chloride Hexahydrate, the active ingredient in Mallebrin, is an aluminium salt (astringent) presented as a topical preparation for oromucosal use. It is employed to reduce excessive secretions and to provide a protective barrier on mucosal surfaces, aiding in conditions such as hyperhidrosis and oral ulcerations.

GNH India supplies Mallebrin as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to EU quality standards and offers reliable global distribution.

Manufacturer / TM Owner

Hermes Arzneimittel Gmbh

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Indications & Clinical Uses

Mallebrin, containing aluminium chloride hexahydrate, is used as a topical astringent for conditions involving excess secretions or mucosal irritation.

  • Hyperhidrosis: reduces excessive sweating on affected skin areas.
  • Oral aphthous ulcers: promotes healing by forming a protective protein barrier.
  • Minor mucosal bleeding: assists hemostasis through protein precipitation.
  • Dermatologic warts: facilitates lesion shrinkage by drying and astringent action.
  • Seborrheic dermatitis: helps control oil secretion and irritation.

How It Works

  • Aluminium chloride hexahydrate precipitates proteins on the surface of mucosal or skin tissues, creating a thin protective film that reduces glandular secretions and exudate. This astringent action also exerts mild antiseptic effects by limiting microbial growth, thereby supporting hemostasis and lesion healing.

Side Effects

Aluminium chloride hexahydrate may cause local and systemic reactions, which are categorized by frequency.

Common Side Effects

  • Local burning sensation.
  • Stinging or tingling at the application site.
  • Dryness of the treated area.
  • Transient taste alteration.
  • Mild irritation or erythema.
  • Temporary discoloration of skin or mucosa.

Serious or Rare Side Effects

  • Allergic contact dermatitis.
  • Severe skin ulceration.
  • Systemic aluminium toxicity (rare with extensive use).
  • Anaphylactic reaction.
  • Persistent mucosal ulceration.
  • Methemoglobinemia (very rare).

Precautions & Warnings

Before using Mallebrin, consider the following safety measures.

  • Avoid application on broken or inflamed mucosa: may increase irritation.
  • Limit frequency of use: excessive application can cause dryness.
  • Assess for aluminium allergy: discontinue if hypersensitivity occurs.
  • Use with caution in renal impairment: reduced aluminium clearance.
  • Consult a healthcare professional before use in pregnancy or breastfeeding.
  • Store at room temperature: keep in original container, protect from moisture and light.

Avoid Interactions

Aluminium chloride hexahydrate can interact with certain medicines; awareness helps prevent adverse outcomes.

Major Interactions (Avoid)

  • Oral aluminium‑containing antacids or supplements: risk of aluminium overload and toxicity.
  • Iron or calcium supplements taken simultaneously: may reduce aluminium absorption and alter efficacy.

Moderate Interactions (Monitor Closely)

  • Topical corticosteroids applied to the same area: may increase local irritation.
  • Other astringent agents (e.g., zinc chloride): additive drying effect.
  • Systemic antibiotics affecting oral flora: possible alteration of normal microbiome.

Frequently Asked Questions

Mallebrin contains aluminium chloride hexahydrate and is employed as a topical astringent to manage conditions such as excessive sweating (hyperhidrosis), oral aphthous ulcers, minor mucosal bleeding, and certain dermatologic lesions where reduction of secretions and formation of a protective barrier are desired.

The compound precipitates proteins on the surface of skin or mucous membranes, creating a thin film that contracts tissue, reduces glandular secretions, and provides a mild antiseptic environment. This astringent action helps control moisture, limit irritation, and promote hemostasis.

The appropriate dose and frequency of Mallebrin are determined by the prescribing healthcare professional based on the specific indication, severity of the condition, and patient factors. Patients should follow the prescriber’s instructions and not alter the regimen without medical advice.

Safety data for aluminium chloride hexahydrate in pregnancy and lactation are limited. Women who are pregnant, planning pregnancy, or breastfeeding should discuss potential risks and benefits with their healthcare provider before using Mallebrin.

To request Mallebrin, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements) and assistance with import documentation.

Mallebrin’s active ingredient, aluminium chloride hexahydrate, offers a strong protein‑precipitating effect that is comparable to other aluminium‑based astringents but may provide a longer duration of action on mucosal surfaces. Compared with zinc chloride or tannic acid preparations, it often produces a more pronounced reduction in secretions, though the choice depends on the clinical scenario and tolerance.

Mallebrin should be stored at room temperature, below 25 °C, in its original packaging to protect it from moisture and light. Keep the container tightly closed when not in use and avoid exposing the product to extreme temperatures or humidity.

Mallebrin is applied topically to the affected skin or mucosal area. The prescriber will advise the appropriate amount, method of application (e.g., swab, drop, or thin film), and frequency. The product is not intended for systemic ingestion.

Serious adverse reactions, although rare, include allergic contact dermatitis, severe skin ulceration, systemic aluminium toxicity, and anaphylaxis. Patients should seek immediate medical attention if they experience widespread rash, swelling, difficulty breathing, or persistent ulceration.

Mallebrin should be avoided in individuals with known hypersensitivity to aluminium salts, those with extensive broken mucosa at the intended site of application, and patients with severe renal impairment unless directed by a physician. Pregnant or breastfeeding women should only use it after consulting their healthcare provider.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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