Maltofer (Ferric Hydroxide Polymaltose Complex)

Maltofer is an oral iron supplement that addresses conditions caused by insufficient iron.

• Iron deficiency anemia: restores hemoglobin concentration and replenishes depleted iron stores.
• Iron deficiency without anemia: supports normal iron metabolism and prevents progression to anemia.
• Chronic blood loss (e.g., gastrointestinal bleeding): compensates for ongoing iron loss and aids recovery of iron balance.

• Ferric Hydroxide Polymaltose Complex provides elemental iron that is absorbed in the duodenum and proximal jejunum. The iron is then incorporated into protoporphyrin IX to form heme, a critical component of hemoglobin, myoglobin, and various iron‑dependent enzymes, thereby restoring normal erythropoiesis and cellular iron reserves.

Adverse reactions may occur with oral iron therapy.

Common Side Effects

• Nausea: mild to moderate discomfort in the stomach.
• Abdominal discomfort: cramping or pain in the abdomen.
• Constipation: reduced bowel movements or hard stools.
• Diarrhea: loose, watery stools.
• Darkened stools: harmless change in stool color.
• Metallic taste: transient metallic sensation in the mouth.

Serious or Rare Side Effects

• Hypersensitivity reactions: rash, itching, or swelling.
• Severe abdominal pain: persistent or worsening pain.
• Anaphylaxis (rare): sudden difficulty breathing, throat swelling.
• Iron overload: signs of excess iron accumulation.
• Significant hypotension: marked drop in blood pressure.

Before prescribing Maltofer, clinicians should evaluate patient-specific factors and monitor therapy.

• Assess iron status before initiating: confirm diagnosis of iron deficiency through laboratory tests.
• Monitor hemoglobin and ferritin levels: adjust therapy based on response.
• Use with caution in patients with inflammatory bowel disease: absorption may be impaired.
• Avoid in known hypersensitivity to ferric hydroxide polymaltose: discontinue if reaction occurs.
• Store at ambient temperature: keep in the original container, protect from moisture and direct sunlight.

Iron supplements can affect the absorption or efficacy of several medicines.

Major Interactions (Avoid)

• Tetracycline antibiotics: chelation reduces antibiotic absorption.
• Fluoroquinolone antibiotics: chelation decreases antibiotic bioavailability.
• Levothyroxine: iron interferes with thyroid hormone absorption.
• Bisphosphonates: concurrent intake diminishes both agents' effectiveness.
• Calcium‑containing antacids: form insoluble complexes, reducing iron uptake.

Moderate Interactions (Monitor Closely)

• Proton pump inhibitors: may lower gastric acidity, modestly reducing iron absorption.
• Food rich in phytates (e.g., whole grains): can modestly decrease iron uptake.
• Vitamin C supplements: may enhance iron absorption, requiring dose adjustment.