Product image of Manasa (Acetylsalicylic Acid, Rosuvastatin) supplied by GNH India

Manasa

Active Ingredient:
Acetylsalicylic Acid, Rosuvastatin
Origin:
EU

Manasa (Acetylsalicylic Acid, Rosuvastatin)

Acetylsalicylic Acid and Rosuvastatin, the active ingredients in Manasa, are an antiplatelet agent and an HMG‑CoA reductase inhibitor presented as oral tablets for cardiovascular disease prevention. They are used to lower cholesterol and reduce platelet aggregation, helping to prevent heart attacks, strokes, and related vascular events in adults at risk.

GNH India supplies Manasa as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Cipros S.R.L.

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Indications & Clinical Uses

  • Manasa combines an antiplatelet and a statin to address cardiovascular risk factors and lipid disorders.
  • Primary prevention of cardiovascular events: lowers the incidence of heart attack and stroke in patients without prior events.
  • Secondary prevention of cardiovascular events: reduces recurrence of myocardial infarction or ischemic stroke after an initial event.
  • Hyperlipidemia: decreases LDL‑cholesterol and total cholesterol levels.
  • Atherosclerotic cardiovascular disease: slows plaque progression and improves arterial health.

How It Works

  • Acetylsalicylic acid irreversibly inhibits cyclooxygenase‑1, decreasing thromboxane A2 production and platelet aggregation. Rosuvastatin competitively blocks HMG‑CoA reductase, reducing hepatic cholesterol synthesis and up‑regulating LDL receptors, which enhances clearance of circulating LDL‑cholesterol.

Side Effects

Manasa may cause a range of adverse reactions, from mild to serious.

Common Side Effects

  • Gastrointestinal discomfort or dyspepsia.
  • Mild headache.
  • Transient elevation of liver enzymes.
  • Muscle aches or weakness.
  • Minor bruising or bleeding at sites of injury.

Serious or Rare Side Effects

  • Severe gastrointestinal bleeding or ulceration.
  • Rhabdomyolysis with muscle breakdown and renal impairment.
  • Anaphylactic or severe hypersensitivity reactions.

Precautions & Warnings

Before prescribing Manasa, clinicians should assess patient history and monitor relevant parameters.

  • Renal or hepatic impairment: adjust monitoring and consider alternative therapy.
  • History of peptic ulcer disease or bleeding: evaluate risk versus benefit.
  • Concomitant use of other anticoagulants or antiplatelet agents: increase bleeding surveillance.
  • Pregnancy or breastfeeding: use only if clearly needed after risk assessment.
  • Store at ambient temperature: keep in original container, protect from moisture and direct sunlight.

Avoid Interactions

Manasa can interact with several drug classes, requiring careful management.

Major Interactions (Avoid)

  • Other antiplatelet or anticoagulant agents (e.g., clopidogrel, warfarin): heightened bleeding risk.
  • Strong CYP3A4 inhibitors (e.g., clarithromycin, itraconazole): may increase rosuvastatin exposure.

Moderate Interactions (Monitor Closely)

  • Non‑steroidal anti‑inflammatory drugs (NSAIDs): additive gastrointestinal irritation.
  • Fibrates (e.g., gemfibrozil): increased risk of myopathy.
  • ACE inhibitors or ARBs: potential for reduced antihypertensive effect.
  • Digoxin: possible increase in serum concentrations.

Frequently Asked Questions

Manasa is prescribed to lower cholesterol levels and reduce platelet aggregation, helping to prevent first‑time and recurrent cardiovascular events such as heart attacks and strokes, and to treat hyperlipidemia in adults at risk.

Acetylsalicylic acid irreversibly blocks cyclooxygenase‑1, lowering thromboxane A2 and platelet clumping. Rosuvastatin competitively inhibits HMG‑CoA reductase, decreasing hepatic cholesterol synthesis and increasing LDL‑receptor activity, which clears LDL‑cholesterol from the bloodstream.

The specific dose of Manasa is determined by the prescribing clinician based on the patient’s clinical condition, laboratory results, and risk profile. Dosage may be adjusted for renal or hepatic function and concomitant medications.

Manasa should only be used during pregnancy or lactation if the potential benefit justifies the potential risk to the fetus or infant. Clinicians must evaluate individual circumstances and discuss alternatives when possible.

To request Manasa, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and any necessary import documentation.

Manasa combines an antiplatelet agent with a high‑potency statin, offering dual risk‑reduction in a single tablet. Compared with separate prescriptions, it may improve adherence, but clinicians should consider individual drug tolerability, interaction profiles, and specific patient needs when selecting therapy.

Manasa tablets should be stored at ambient temperature, below 25 °C, in the original packaging to protect from moisture and light. Keep the container tightly closed and out of reach of children.

Manasa is taken orally, usually with a glass of water. It can be taken with or without food, but patients should follow the prescribing physician’s instructions regarding timing and any dietary considerations.

Serious risks include gastrointestinal bleeding, severe allergic reactions, and rare cases of rhabdomyolysis leading to renal failure. Patients should report any unusual bruising, muscle pain, dark urine, or signs of an allergic response promptly.

Manasa is contraindicated in patients with known hypersensitivity to aspirin, rosuvastatin, or any component of the formulation, as well as those with active bleeding disorders, severe liver disease, or a history of statin‑induced rhabdomyolysis.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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