Mandaprin (Acetylsalicylic Acid)

Acetylsalicylic Acid (aspirin) is used to manage conditions involving pain, fever, inflammation, and thrombotic cardiovascular risk.

• Pain relief: reduces mild to moderate pain such as headache, musculoskeletal discomfort, and dental pain.
• Fever reduction: lowers elevated body temperature associated with infections or inflammatory states.
• Inflammation reduction: diminishes swelling and redness in conditions like arthritis.
• Cardiovascular event prevention: lowers risk of myocardial infarction and ischemic stroke in at‑risk adults.

• Acetylsalicylic Acid irreversibly inhibits cyclooxygenase‑1 (COX‑1) and cyclooxygenase‑2 (COX‑2) enzymes, preventing the conversion of arachidonic acid to prostaglandins and thromboxanes. The reduction of prostaglandins mediates analgesic, antipyretic and anti‑inflammatory effects, while decreased thromboxane A2 synthesis impairs platelet aggregation, providing antiplatelet activity. Additionally, the acetylation of serine residues in the COX enzymes leads to a prolonged suppression of enzyme activity, which contributes to the sustained therapeutic actions observed with single doses.

Acetylsalicylic Acid may cause a range of adverse reactions, varying from mild to severe.

Common Side Effects

• Gastrointestinal discomfort: nausea, dyspepsia or heartburn.
• Minor bleeding: easy bruising or prolonged bleeding from cuts.
• Tinnitus: ringing in the ears, especially at higher doses.
• Headache: mild to moderate headache episodes.

Serious or Rare Side Effects

• Gastrointestinal ulcer or bleeding: severe stomach or intestinal ulceration.
• Hemorrhagic stroke: bleeding within the brain.
• Severe allergic reaction: rash, swelling, or anaphylaxis.
• Reye’s syndrome: rare but serious condition in children with viral illness.

Before using Acetylsalicylic Acid, consider the following precautions to minimize risk.

• Assess bleeding risk: evaluate patient history for ulcers or coagulopathy.
• Use lowest effective dose: limit exposure while achieving therapeutic goal.
• Avoid in children with viral infections: risk of Reye’s syndrome.
• Monitor renal function: NSAIDs may affect kidney performance in susceptible individuals.
• Caution with concurrent anticoagulants: increased bleeding potential.
• Store at room temperature: keep in the original container, protect from moisture.

Acetylsalicylic Acid can interact with several medicines; some combinations should be avoided while others require monitoring.

Major Interactions (Avoid)

• Warfarin or other oral anticoagulants: heightened bleeding risk.
• Other NSAIDs or aspirin-containing products: additive gastrointestinal toxicity.
• Systemic corticosteroids: increased risk of ulceration and bleeding.

Moderate Interactions (Monitor Closely)

• Selective serotonin reuptake inhibitors (SSRIs): may enhance bleeding tendency.
• ACE inhibitors or diuretics: potential reduction in renal function.
• Lithium: aspirin may increase lithium serum levels.