Product image of Manidipina Aurobindo (Manidipine Dihydrochloride) supplied by GNH India

Manidipina Aurobindo

Active Ingredient:
Manidipine Dihydrochloride
Origin:
EU

Manidipina Aurobindo (Manidipine Dihydrochloride)

Manidipine Dihydrochloride, the active ingredient in Manidipina Aurobindo, is a calcium channel blocker presented as an oral tablet for oral use. It lowers elevated blood pressure in adult patients with hypertension by relaxing vascular smooth muscle.\n\nGNH India supplies Manidipina Aurobindo as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, with distribution across the European Union and other global markets. The product meets EU quality standards and is manufactured under strict GMP conditions.

Manufacturer / TM Owner

Aurobindo Pharma (Italia) S.R.L.

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Indications & Clinical Uses

  • Manidipine is a calcium channel blocker indicated for the management of hypertension.\n\nEssential hypertension: lowers systolic and diastolic pressure in patients with primary hypertension.\nIsolated systolic hypertension: provides arterial vasodilation to reduce elevated systolic pressure.\nHypertension in elderly patients: improves blood pressure control with once‑daily dosing.

How It Works

  • Manidipine selectively inhibits L‑type calcium channels in vascular smooth muscle, reducing calcium influx. This leads to relaxation of arterial smooth muscle, vasodilation, and a consequent decrease in peripheral vascular resistance, which lowers systemic blood pressure.

Side Effects

  • Manidipine may cause adverse reactions that vary in frequency and severity.\n\nCommon Side Effects:\n- Headache\n- Flushing\n- Peripheral edema\n- Dizziness\n\nSerious or Rare Side Effects:\n- Severe hypotension\n- Angioedema\n- Hepatic enzyme elevation

Precautions & Warnings

  • Before initiating therapy, several safety considerations should be observed.\n\nMonitor blood pressure: measure regularly after starting treatment.\nAssess renal function: adjust use in patients with severe renal impairment.\nCaution in hepatic disease: use with care in liver dysfunction.\nAvoid abrupt discontinuation: taper to prevent rebound hypertension.\nStore at ambient temperature below 25°C: keep in the original packaging, protect from moisture.

Avoid Interactions

  • Manidipine can interact with other medicines, requiring attention to avoid adverse outcomes.\n\nMajor Interactions (Avoid):\n- Concomitant use with strong CYP3A4 inhibitors (e.g., ketoconazole): may increase plasma levels.\n- Co‑administration with other antihypertensives (e.g., ACE inhibitors) can cause excessive hypotension.\n- Use with grapefruit juice: can elevate drug concentration.\n\nModerate Interactions (Monitor Closely):\n- Non‑dihydropyridine calcium channel blockers (e.g., verapamil): may enhance cardiac effects.\n- Diuretics: may increase risk of electrolyte imbalance and hypotension.

Frequently Asked Questions

Manidipina contains manidipine dihydrochloride, a calcium channel blocker that is prescribed to lower high blood pressure in adults diagnosed with hypertension.

Manidipine selectively blocks L‑type calcium channels in vascular smooth muscle, reducing calcium entry, causing arterial relaxation, vasodilation, and a subsequent drop in peripheral resistance and blood pressure.

The dose of Manidipina is determined by the prescribing healthcare professional based on the patient’s condition, response, and any concomitant therapies. Patients should follow the prescriber’s instructions.

The safety of manidipine in pregnancy and lactation has not been established. It should only be used if the potential benefit justifies the potential risk to the fetus or infant, and under medical supervision.

To request Manidipina, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Manidipina belongs to the dihydropyridine calcium‑channel blocker class, which primarily causes arterial vasodilation. Compared with ACE inhibitors or beta‑blockers, it has a different side‑effect profile and may be preferred when a strong vasodilatory effect is needed, but choice depends on individual patient factors.

Manidipina should be stored at ambient temperature below 25 °C, in its original packaging, protected from moisture and direct sunlight to maintain stability.

Manidipina is taken orally, usually once daily, with or without food, as directed by the prescribing clinician. Swallow the tablet whole with a glass of water.

Serious risks include severe hypotension, angioedema, and significant liver enzyme elevations. Patients should seek immediate medical attention if they experience symptoms such as sudden dizziness, swelling of the face or throat, or jaundice.

Manidipina is contraindicated in patients with known hypersensitivity to manidipine or any component of the formulation, and should be used with caution in individuals with severe hepatic impairment or uncontrolled heart failure.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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