Product image of Manidipina Zentiva (Manidipine Dihydrochloride) supplied by GNH India

Manidipina Zentiva

Active Ingredient:
Manidipine Dihydrochloride
Origin:
EU

Manidipina Zentiva (Manidipine Dihydrochloride)

Manidipine, the active ingredient in Manidipina Zentiva, is a calcium channel blocker (dihydropyridine) presented as a tablet for oral use. It is employed to treat essential hypertension in adult patients.

GNH India supplies Manidipina Zentiva as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Zentiva Italia S.R.L.

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Indications & Clinical Uses

Manidipina Zentiva is a calcium‑channel‑blocking antihypertensive used to manage elevated blood pressure.

  • Essential hypertension: lowers systolic and diastolic pressure to target levels.
  • Primary hypertension: assists in achieving recommended blood pressure control.
  • Elevated blood pressure: contributes to overall cardiovascular risk reduction.

How It Works

  • Manidipine blocks L‑type calcium channels in vascular smooth muscle, inhibiting calcium influx. This causes relaxation of arterial smooth muscle, leading to vasodilation and a reduction in peripheral vascular resistance, which lowers systemic blood pressure.

Side Effects

Manidipina Zentiva may cause a range of adverse reactions.

Common Side Effects

  • Headache: mild to moderate intensity.
  • Flushing: transient warmth and redness of the skin.
  • Peripheral edema: swelling of the lower limbs.
  • Dizziness or light‑headedness.
  • Nausea: occasional gastrointestinal upset.
  • Tachycardia: increased heart rate.

Serious or Rare Side Effects

  • Severe hypotension: marked drop in blood pressure requiring medical attention.
  • Allergic reaction: rash, itching, or swelling.
  • Angioedema: swelling of face, lips, or throat.
  • Hepatic injury: abnormal liver function tests.
  • Cardiac conduction abnormalities: heart block or arrhythmias.

Precautions & Warnings

Before initiating therapy, consider the following safety measures.

  • Blood pressure monitoring: ensure adequate control and avoid excessive drops.
  • Hepatic impairment: use with caution and adjust if necessary.
  • Concomitant antihypertensives: monitor for additive hypotensive effects.
  • Cardiovascular disease: assess risk of reflex tachycardia.
  • Abrupt discontinuation: taper to prevent rebound hypertension.
  • Store at below 25°C: keep in the original pack, protect from moisture.

Avoid Interactions

Manidipina Zentiva can interact with several drug classes.

Major Interactions (Avoid)

  • Strong CYP3A4 inhibitors (e.g., ketoconazole): may increase plasma levels.
  • Other calcium‑channel blockers: additive vasodilatory effect.
  • Grapefruit juice: can raise drug concentration.
  • Concurrent antihypertensives: risk of severe hypotension.
  • Rifampicin: may reduce efficacy by inducing metabolism.

Moderate Interactions (Monitor Closely):\n- Diuretics: may enhance blood pressure lowering.

  • Beta‑blockers: monitor heart rate and blood pressure.
  • NSAIDs: may blunt antihypertensive response.
  • ACE inhibitors or ARBs: watch for renal function changes.
  • Lipid‑lowering agents (e.g., statins): potential CYP3A4 competition.

Frequently Asked Questions

Manidipina Zentiva contains manidipine, a calcium‑channel blocker prescribed to lower high blood pressure in adults with essential hypertension, helping to reduce the risk of cardiovascular complications.

Manidipine blocks L‑type calcium channels in arterial smooth muscle, preventing calcium entry, which relaxes the vessels, decreases peripheral resistance, and consequently lowers systemic blood pressure.

The appropriate dose of Manidipina Zentiva is determined by the prescribing clinician based on the patient’s blood pressure, response to therapy, and any co‑existing medical conditions.

Safety of manidipine in pregnancy or lactation has not been established. It should only be used if the potential benefit justifies the potential risk to the fetus or infant, and under medical supervision.

Submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and import documentation.

Manidipine belongs to the dihydropyridine calcium‑channel blocker class, offering potent vasodilation with a relatively low incidence of reflex tachycardia compared with some older agents, and is often used when ACE inhibitors or beta‑blockers are insufficient or not tolerated.

Store tablets at temperatures below 25 °C in their original container, protected from moisture and direct sunlight. Keep out of reach of children and do not use after the expiry date.

Manidipina Zentiva is taken orally, usually once daily with or without food, as directed by a healthcare professional. Swallow the tablet whole with a glass of water.

Serious adverse events can include severe hypotension, allergic reactions such as angioedema, hepatic injury, and cardiac conduction disturbances. Patients should seek immediate medical attention if they experience these symptoms.

Manidipina Zentiva is contraindicated in patients with known hypersensitivity to manidipine or any component of the formulation, and should be used with caution in individuals with severe hepatic impairment or unstable cardiac conditions.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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