Product image of Manidipine Teva (Manidipine Dihydrochloride) supplied by GNH India

Manidipine Teva

Active Ingredient:
Manidipine Dihydrochloride
Origin:
EU

Manidipine Teva (Manidipine Dihydrochloride)

Manidipine, the active ingredient in Manidipine Teva, is a calcium channel blocker presented as an oral tablet for systemic use. It selectively inhibits L‑type calcium channels in vascular smooth muscle, producing vasodilation that lowers elevated blood pressure in adults with hypertension, thereby contributing to the management of cardiovascular risk.

GNH India supplies Manidipine Teva as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, ensuring consistent quality and regulatory compliance across global markets.

Manufacturer / TM Owner

Teva Santé

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Indications & Clinical Uses

Manidipine is used to treat hypertension, a condition characterized by chronically elevated arterial pressure.

  • Essential hypertension: reduces both systolic and diastolic blood pressure in patients with primary hypertension.
  • Secondary hypertension: may be added to other agents to achieve target blood pressure when an underlying cause is identified.
  • Isolated systolic hypertension: helps control elevated systolic pressure, particularly in older adults.

How It Works

  • Manidipine blocks L‑type calcium channels on vascular smooth‑muscle cells, preventing calcium influx that is required for muscle contraction. This inhibition leads to relaxation of arterial smooth muscle, causing peripheral vasodilation and a consequent decrease in systemic vascular resistance. The resulting reduction in resistance lowers arterial pressure without significant negative inotropic effects on the heart, providing a sustained antihypertensive effect.

Side Effects

Manidipine may be associated with several adverse reactions, which are categorized by frequency and severity.

Common Side Effects

  • Headache: mild to moderate pain often occurring shortly after initiation.
  • Flushing: transient warmth and redness of the skin.
  • Peripheral edema: swelling of the lower limbs due to fluid accumulation.
  • Dizziness: sensation of light‑headedness, especially when standing quickly.

Serious or Rare Side Effects

  • Severe hypotension: marked drop in blood pressure that can cause fainting.
  • Allergic reaction: rash, itching, swelling, or anaphylaxis in rare cases.
  • Liver injury: abnormal liver function tests or hepatitis.

Precautions & Warnings

When prescribing Manidipine, clinicians should consider several precautionary measures to ensure safe use.

  • Blood pressure monitoring: regularly assess to avoid excessive hypotension.
  • Hepatic impairment: use with caution and consider dose adjustment.
  • Concurrent antihypertensives: monitor for additive blood pressure lowering.
  • Elderly patients: start at a lower dose and titrate slowly.
  • Store at room temperature below 25°C: keep in the original container, protect from moisture.

Avoid Interactions

Manidipine can interact with other medicines, influencing its efficacy or safety.

Major Interactions (Avoid)

  • Strong CYP3A4 inhibitors (e.g., ketoconazole): may increase plasma concentrations.
  • Other antihypertensives: additive hypotensive effect can lead to severe blood pressure drop.
  • Grapefruit juice: can raise drug levels and risk of adverse events.

Moderate Interactions (Monitor Closely)

  • CYP3A4 inducers (e.g., rifampin): may reduce effectiveness.
  • Non‑dihydropyridine calcium channel blockers: may alter cardiac conduction.
  • NSAIDs: can blunt antihypertensive response and affect renal function.

Frequently Asked Questions

Manidipine Teva is an oral antihypertensive medication indicated for the management of high blood pressure (hypertension). By lowering systemic arterial pressure, it helps reduce the risk of cardiovascular events such as stroke and heart attack in adult patients.

Manidipine blocks L‑type calcium channels on vascular smooth‑muscle cells, preventing calcium entry that drives muscle contraction. This causes relaxation of arterial walls, leading to vasodilation and a decrease in peripheral vascular resistance, which in turn lowers blood pressure.

The appropriate dose of Manidipine Teva is determined by the prescribing clinician based on the individual’s blood pressure, response to therapy, and any co‑existing medical conditions. The prescriber will select an initial dose and adjust it as needed to achieve target blood pressure.

Manidipine is generally not recommended for use during pregnancy or while breastfeeding because safety data are limited. Healthcare providers usually consider alternative antihypertensive agents with established safety profiles for pregnant or lactating patients.

To order Manidipine Teva, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Manidipine belongs to the dihydropyridine class of calcium channel blockers, offering potent vasodilation with a relatively low incidence of reflex tachycardia compared with some alternatives. Compared with agents such as amlodipine, it may provide a smoother blood‑pressure profile, but the choice of therapy depends on individual patient characteristics and physician judgment.

Manidipine tablets should be stored at room temperature below 25 °C, in the original packaging, and protected from moisture and direct sunlight. Keeping the product in a dry, cool environment helps maintain its stability and potency throughout its shelf life.

Manidipine is taken orally, usually once daily, with or without food as directed by the prescriber. Swallow the tablet whole with a glass of water and follow any specific timing instructions provided by the healthcare professional.

The most serious risks include severe hypotension, which can cause fainting or organ hypoperfusion, allergic reactions such as anaphylaxis, and rare cases of liver injury. Patients should seek immediate medical attention if they experience symptoms like sudden dizziness, rash, swelling, or jaundice.

Manidipine is contraindicated in patients with known hypersensitivity to the drug or any component of the formulation, in those with severe hypotension or cardiogenic shock, and in individuals with certain severe cardiac conditions where rapid blood‑pressure reduction could be harmful.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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