Product image of Manidipino Aurovitas (Manidipine Dihydrochloride) supplied by GNH India

Manidipino Aurovitas

Active Ingredient:
Manidipine Dihydrochloride
Origin:
EU

Manidipino Aurovitas (Manidipine Dihydrochloride)

Manidipine, the active ingredient in Manidipino Aurovitas, is a calcium channel blocker presented as an oral tablet for systemic use. It is indicated for the management of hypertension in adult patients, helping to lower elevated blood pressure.\n\nGNH India supplies Manidipino Aurovitas as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The product meets European Union standards for safety and efficacy.

Manufacturer / TM Owner

Aurovitas Spain,s.A.U.

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Indications & Clinical Uses

  • Manidipine is a dihydropyridine calcium channel blocker used in the treatment of hypertension.\n\nEssential hypertension: lowers elevated systolic and diastolic pressure.\nPrimary hypertension: helps achieve target blood‑pressure goals.\nHypertensive patients with cardiovascular risk: contributes to overall risk reduction.

How It Works

  • Manidipine blocks L‑type calcium channels in vascular smooth‑muscle cells, reducing calcium influx. This inhibition leads to relaxation of arterial smooth muscle, vasodilation, and a consequent decrease in peripheral vascular resistance, which lowers systemic blood pressure in hypertensive individuals.

Side Effects

  • Manidipine may cause a range of adverse reactions, most of which are mild and reversible.\n\nCommon Side Effects:\n- Headache: mild to moderate intensity.\n- Flushing: transient warmth and redness of the skin.\n- Peripheral edema: swelling of ankles or lower legs.\n- Dizziness: sensation of light‑headedness, especially on standing.\n- Nausea: mild gastrointestinal discomfort.\n\nSerious or Rare Side Effects:\n- Severe hypotension: marked drop in blood pressure requiring medical attention.\n- Myocardial infarction: rare occurrence of heart attack.\n- Hepatic dysfunction: abnormal liver enzyme elevations.\n- Allergic reactions: rash, pruritus, or urticaria.\n- Angioedema: swelling of face, lips, or throat.\n- Cardiac conduction abnormalities: bradyarrhythmias or heart block.

Precautions & Warnings

  • Before initiating therapy, clinicians should consider several safety measures.\n\nMonitor blood pressure: ensure adequate control without excessive drop.\nAssess hepatic function: adjust use in patients with liver impairment.\nCaution in elderly: start at lower dose due to increased sensitivity.\nAvoid abrupt discontinuation: taper to prevent rebound hypertension.\nUse with caution in heart‑failure patients: monitor for fluid retention.\nStore at room temperature: keep in original packaging, protect from moisture and direct sunlight.

Avoid Interactions

  • Manidipine can interact with several drug classes, influencing its efficacy or safety profile.\n\nMajor Interactions (Avoid):\n- Concomitant antihypertensives: risk of additive hypotension.\n- Strong CYP3A4 inhibitors (e.g., ketoconazole, clarithromycin): increase plasma concentrations.\n- Grapefruit juice: may elevate drug levels.\n\nModerate Interactions (Monitor Closely):\n- Diuretics: enhanced diuretic effect and electrolyte shifts.\n- Beta‑blockers: additive blood‑pressure lowering effect.\n- NSAIDs: may attenuate antihypertensive response.

Frequently Asked Questions

Manidipino Aurovitas contains manidipine, a calcium‑channel‑blocking agent indicated for the treatment of hypertension. It helps lower elevated systolic and diastolic blood pressure in adult patients, reducing the risk of cardiovascular complications associated with high blood pressure.

Manidipine selectively blocks L‑type calcium channels in vascular smooth‑muscle cells, decreasing calcium entry. This causes relaxation of arterial smooth muscle, leading to vasodilation, reduced peripheral resistance, and ultimately a fall in systemic blood pressure.

The appropriate dose of Manidipino Aurovitas is determined by the prescribing clinician based on the patient’s clinical condition, response to therapy, and any relevant comorbidities. Dosage adjustments are made according to individual therapeutic needs.

Safety data for manidipine in pregnancy and lactation are limited. It should only be used if the potential benefit justifies the potential risk to the fetus or infant, and the decision must be made by a qualified healthcare professional.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and any necessary import documentation.

Manidipine belongs to the dihydropyridine calcium‑channel‑blocker class, which primarily causes arterial vasodilation. Compared with ACE inhibitors or ARBs, it may have a more pronounced effect on peripheral resistance but a lower impact on renin‑angiotensin pathways. Choice of therapy depends on patient profile and comorbid conditions.

Manidipino Aurovitas tablets should be stored at room temperature, below 25 °C, in the original blister pack or container. Keep the product away from moisture, direct sunlight, and extreme temperatures to maintain potency.

The medication is taken orally, usually once daily, with or without food as directed by the prescribing physician. Swallow the tablet whole with a glass of water; do not crush or chew unless specifically instructed.

Serious adverse events, although rare, include severe hypotension, myocardial infarction, hepatic dysfunction, allergic reactions such as angioedema, and cardiac conduction abnormalities. Patients should seek immediate medical attention if they experience symptoms like fainting, chest pain, severe dizziness, or swelling of the face or throat.

Manidipino Aurovitas is contraindicated in patients with known hypersensitivity to manidipine or any component of the formulation, and in individuals with severe aortic stenosis or unstable angina. Caution is also advised for patients with significant hepatic impairment or those taking interacting medications.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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