Product image of Manitol Viaflo Baxter (Mannitol) supplied by GNH India

Manitol Viaflo Baxter

Active Ingredient:
Mannitol
Origin:
EU

Manitol Viaflo Baxter (Mannitol)

Mannitol, the active ingredient in Manitol Viaflo Baxter, is an osmotic diuretic presented as a solution for injection for intravenous use. It is employed to promote diuresis and to reduce elevated intracranial or intraocular pressure in appropriate clinical settings.

GNH India supplies Manitol Viaflo Baxter as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, transplant centres and pharmacies worldwide.

Manufacturer / TM Owner

Baxter Czech Spol. S R.O.

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Indications & Clinical Uses

Manitol Viaflo Baxter is used in clinical situations where rapid osmotic diuresis or pressure reduction is required.

  • Cerebral edema: helps lower intracranial pressure and limit brain swelling.
  • Acute glaucoma: reduces intraocular pressure to preserve vision.
  • Oliguric renal failure: increases urine output to support renal clearance.

How It Works

  • Mannitol creates an osmotic gradient in the renal tubules by remaining largely unmetabolized in the filtrate. This gradient draws water into the tubular lumen, increasing urinary flow and promoting diuresis. In the central nervous system and eye, the osmotic shift pulls fluid from tissues into the vasculature, thereby lowering intracranial and intraocular pressures.

Side Effects

Mannitol injection may be associated with several adverse reactions.

Common Side Effects

  • Headache: mild to moderate discomfort often related to fluid shifts.
  • Nausea or vomiting: gastrointestinal upset following rapid infusion.
  • Thirst or dry mouth: due to osmotic draw of water.
  • Electrolyte imbalance: mild hyponatremia or hypokalemia.
  • Hypotension: transient drop in blood pressure during administration.

Serious or Rare Side Effects

  • Acute renal failure: especially in patients with pre‑existing kidney disease.
  • Pulmonary edema: volume overload in susceptible individuals.
  • Severe electrolyte disturbances: marked hypernatremia or severe hyponatremia.
  • Anaphylactic reaction: rare but potentially life‑threatening hypersensitivity.

Precautions & Warnings

When considering Mannitol injection, clinicians should observe several safety measures.

  • Renal function: assess baseline kidney status before initiating therapy.
  • Electrolytes: monitor serum sodium, potassium and osmolality during treatment.
  • Cardiac status: watch for signs of volume overload in patients with heart failure.
  • Intracranial dynamics: avoid rapid bolus in traumatic brain injury where abrupt shifts may worsen injury.
  • Pregnancy: use only if the anticipated benefit justifies potential risk to the fetus.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze.

Avoid Interactions

Mannitol may interact with other medicines, requiring careful management.

Major Interactions (Avoid)

  • Loop diuretics: additive diuretic effect can cause severe electrolyte loss.
  • ACE inhibitors or ARBs: increased risk of hypotension and renal impairment.
  • Insulin: osmotic shifts may potentiate hypoglycaemia.
  • Nephrotoxic agents: concurrent use may exacerbate renal injury.

Moderate Interactions (Monitor Closely)

  • Thyroid hormone preparations: altered serum concentrations may occur.
  • Antihypertensive drugs: dose adjustments may be needed due to additive blood‑pressure lowering effects.

Frequently Asked Questions

Manitol Viaflo Baxter is an intravenous mannitol solution used to promote osmotic diuresis and to lower elevated intracranial or intraocular pressure. It is commonly employed in the management of cerebral edema, acute glaucoma, and oliguria associated with renal failure.

Mannitol acts as an osmotic agent that remains largely unmetabolized in the renal tubules. By creating an osmotic gradient, it draws water into the tubular lumen, increasing urine output, and pulls fluid from brain or eye tissues into the bloodstream, thereby reducing pressure in those compartments.

The specific dose of Manitol Viaflo Baxter is determined by the prescribing clinician based on the patient’s condition, weight, renal function and therapeutic goals. Healthcare professionals calculate the appropriate infusion rate and total volume for each individual case.

Safety data for mannitol in pregnancy and lactation are limited. It should only be used when the potential benefit to the mother outweighs any possible risk to the fetus or infant, and the decision must be made by a qualified healthcare provider.

To place an order, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain if needed) and import documentation.

Mannitol is a widely used osmotic diuretic with a rapid onset of action and predictable renal excretion. Compared with hypertonic saline, mannitol provides both diuretic and pressure‑reducing effects, but may carry a higher risk of electrolyte disturbances. Choice of agent depends on the clinical scenario and physician preference.

Manitol Viaflo Baxter should be stored at 2‑8 °C in a refrigerator. Keep the vial in its original packaging, protect it from light, and avoid freezing or shaking the solution. Inspect for particulate matter before use.

The product is supplied as a sterile solution for injection and is administered intravenously. It can be given as a slow infusion or bolus, depending on the indication and the prescribing clinician’s protocol. Administration should be performed by qualified healthcare personnel in a controlled setting.

Serious risks include acute renal failure, severe electrolyte imbalances (especially hypernatremia or hyponatremia), pulmonary edema from fluid overload, and rare anaphylactic reactions. Patients should be closely monitored for changes in renal function, fluid status and vital signs during treatment.

Mannitol is contraindicated in patients with known hypersensitivity to mannitol, severe renal impairment, active pulmonary edema, uncontrolled heart failure, or severe electrolyte disturbances. It should also be used with caution in individuals with intracranial hemorrhage where rapid osmotic shifts could worsen the condition.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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