Product image of Mannitol Βιοσερ (Mannitol) supplied by GNH India

Mannitol Βιοσερ

Active Ingredient:
Mannitol
Origin:
EU

Mannitol Βιοσερ (Mannitol)

Mannitol, the active ingredient in Mannitol Βιοσερ, is an osmotic diuretic presented as an intravenous solution for IV use. It is employed to lower intracranial and intraocular pressure, treat cerebral edema, and promote diuresis in acute renal failure.

GNH India supplies Mannitol Βιοσερ as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals worldwide.

Manufacturer / TM Owner

Vioser S.A.

1
Pack/s
This product is added to your enquiry list

Request a Quote

Please fill out the form below and our team will get back to you shortly with pricing and further information.

A minimum order value applies. Our team will confirm the exact amount or quantity after reviewing your requirements.

Indications & Clinical Uses

Mannitol is an osmotic diuretic used in conditions that require rapid reduction of fluid pressure within the central nervous system or the eye.

  • Intracranial pressure: lowers pressure to prevent brain herniation.
  • Cerebral edema: reduces swelling and improves neurological outcomes.
  • Acute renal failure: promotes diuresis to aid renal clearance.
  • Intraocular pressure: decreases pressure to manage acute glaucoma attacks.

How It Works

  • Mannitol increases extracellular osmotic pressure by remaining largely confined to the vascular compartment after intravenous administration. This osmotic gradient draws water from intracellular and interstitial spaces into the bloodstream, expanding plasma volume, enhancing renal filtration, and lowering pressure in the brain and eye.

Side Effects

Mannitol may cause a range of adverse reactions, from mild to severe. Monitoring patients for these effects is essential during therapy.

Common Side Effects

  • Headache: mild to moderate discomfort often reported during infusion.
  • Nausea: transient feeling of queasiness.
  • Electrolyte imbalance: changes such as hyponatremia or hypokalemia.
  • Thirst: increased desire for fluids.

Serious or Rare Side Effects

  • Pulmonary edema: fluid accumulation in the lungs requiring urgent care.
  • Severe dehydration: excessive fluid loss leading to hypotension.
  • Anaphylaxis: rare allergic reaction with rash, swelling, and breathing difficulty.
  • Cardiac arrhythmia: irregular heart rhythm potentially life‑threatening.

Precautions & Warnings

Before initiating Mannitol therapy, clinicians should consider several safety measures.

  • Assess renal function: avoid or adjust use in patients with impaired kidneys.
  • Monitor electrolytes: watch for hyponatremia, hypokalemia, and other disturbances.
  • Avoid rapid infusion: administer over the recommended period to reduce cardiovascular stress.
  • Use with caution in heart failure: risk of fluid overload.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze.

Avoid Interactions

Mannitol can interact with other medications, influencing efficacy and safety.

Major Interactions (Avoid)

  • Loop diuretics: additive diuretic effect may cause severe electrolyte loss.
  • Insulin: osmotic shifts can enhance hypoglycemia.
  • Nephrotoxic agents: increased risk of renal impairment.

Moderate Interactions (Monitor Closely)

  • ACE inhibitors: may potentiate hypotension.
  • Antihypertensives: additive blood‑pressure lowering effect.
  • Contrast media: heightened risk of renal dysfunction.

Frequently Asked Questions

Mannitol Βιοσερ is an intravenous osmotic diuretic indicated for rapid reduction of elevated intracranial pressure, treatment of cerebral edema, promotion of diuresis in acute renal failure, and lowering of intraocular pressure in acute glaucoma situations. It is administered under medical supervision in hospital or clinic settings.

Mannitol works by increasing the osmotic pressure of the extracellular fluid after intravenous infusion. This draws water from swollen brain tissue, the eye, and peripheral tissues into the vascular compartment, expanding plasma volume, enhancing renal filtration, and thereby reducing pressure in the affected compartments.

The dosage of Mannitol Βιοσερ is individualized and determined by the prescribing clinician based on the patient’s condition, weight, renal function, and therapeutic goals. Specific dosing regimens are not provided here and should follow the prescriber’s orders and local guidelines.

Safety data for Mannitol during pregnancy and lactation are limited, and the product is classified as having an unknown pregnancy category. It should be used only if the potential benefit justifies any potential risk to the fetus or infant, and decisions should be made by the treating physician.

To order Mannitol Βιοσερ, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements), and import documentation.

Mannitol is a non‑ionic sugar alcohol that creates an osmotic gradient without being metabolized, making it effective for rapid fluid shifts. Compared with hypertonic saline, Mannitol provides a greater diuretic effect and is less likely to cause hypernatremia, but both require careful monitoring of electrolytes and fluid balance.

Mannitol intravenous solution should be stored at 2‑8 °C, kept refrigerated, protected from light, and never frozen. Before use, inspect the vial for particulate matter or discoloration, and allow the solution to reach room temperature if required for infusion, following aseptic technique.

Mannitol is administered by slow intravenous infusion, typically through a peripheral or central line. The infusion rate and total volume are set by the prescriber to achieve the desired osmotic effect while minimizing cardiovascular stress. Continuous monitoring of vital signs and urine output is recommended during administration.

Serious risks include pulmonary edema, severe dehydration, anaphylactic reactions, and cardiac arrhythmias. Patients should be monitored for signs of fluid overload, sudden drops in blood pressure, respiratory distress, and any allergic manifestations. Prompt medical intervention is required if any of these events occur.

Mannitol is contraindicated in patients with known hypersensitivity to mannitol, severe dehydration, active intracranial bleeding, uncontrolled heart failure, or severe renal impairment where fluid removal could worsen the condition. Clinicians should assess each patient’s medical history before initiating therapy.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

Disclaimer

At GNH India, we aim to provide information that is expert-reviewed, accurate, and reliable. However, all content on this platform is intended for general informational purposes only and does not constitute professional medical advice, diagnosis, or treatment. While efforts are made to maintain accuracy and currency, the information may contain errors, omissions, or may not reflect the latest developments. Always consult a qualified healthcare professional regarding any medical concerns.

All product names, brand names, trademarks and registered trademarks displayed on this website are the property of their respective owners. This website and its operator are not affiliated with, endorsed by, or authorized by any such trade mark owners unless expressly stated. Any reference to product names or trademarks is made solely for descriptive and informational purposes. No commercial relationship, sponsorship, approval, or association with any trademark owner should be inferred. Information provided herein does not constitute promotion, advertising, or an offer for sale of any medicinal product and is intended solely for general informational purposes.

All trademarks and brand names displayed on this website are used strictly in accordance with the provisions of the Trade Marks Act, 1999, specifically Sections 30 and 30(1) governing fair use. Trademark ownership has been accurately attributed under the "Manufacturer/ TM Owner" section in compliance with statutory requirements.

Ordering Process

Simple, Secure, and Seamless

Learn how our streamlined ordering process guarantees fast, compliant, and reliable access to essential medicines worldwide.

Quote request form

01

Submit Quote Request Form

Tell us what medications you need by filling out our simple form and uploading a valid document.

Price estimate review

02

We Review & Send Estimate

Our licensed pharmacists will verify your details and provide you with a detailed cost estimate.

Secure payment

03

Confirm & Make Payment

Discuss any queries, approve the estimate, and complete your payment.

Worldwide delivery

04

Get Delivered

Your medicines, safely packed and delivered to your door or nearest airport — hassle-free.

Quality You Can Trust

Our internationally recognized certifications underscore our commitment to safety, quality, and excellence.