Mannitol En Flacon Verre B. Braun (Mannitol)

Mannitol raises plasma osmolality, creating an osmotic gradient that pulls water from cells and interstitial spaces into the bloodstream. This expands intravascular volume, enhances renal filtration, and reduces pressure in the brain and eyes by decreasing tissue water content.

The dose of Mannitol is individualized by the prescribing clinician based on the patient’s condition, weight, renal function and response. Dosage regimens are determined in a hospital setting and are not standardized in public literature.

Mannitol’s safety in pregnancy and lactation has not been definitively established. It should be used only when the potential benefit to the mother outweighs any possible risk to the fetus or infant, and under close medical supervision.

To place an order, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain if needed) and import documentation.

Mannitol is a non‑metabolizable sugar alcohol, whereas alternatives like hypertonic saline provide sodium‑based osmotic effects. Mannitol’s rapid renal clearance makes it useful for short‑term pressure reduction, while hypertonic saline may be preferred when sustained plasma sodium elevation is desired.

Mannitol solution for injection should be stored at 2‑8 °C, protected from light, and kept in its original container. It must not be frozen or shaken, and any vial that appears cloudy or contains particles should be discarded.

Mannitol is given intravenously, typically as a sterile solution diluted in compatible IV fluids. Administration rate and concentration are determined by the treating physician, and infusion should be monitored for hemodynamic changes and urine output.

Serious risks include severe allergic reactions, pulmonary edema from fluid overload, worsening renal failure, marked electrolyte disturbances, and cardiac arrhythmias. Prompt recognition and supportive care are essential if any of these events occur.

Mannitol is contraindicated in patients with known hypersensitivity to mannitol, severe dehydration, active intracranial bleeding, uncontrolled heart failure, or severe renal impairment where fluid removal could be harmful.