Product image of Mannitol Fresenius (Mannitol) supplied by GNH India

Mannitol Fresenius

Active Ingredient:
Mannitol
Origin:
EU

Mannitol Fresenius (Mannitol)

Mannitol, the active ingredient in Mannitol Fresenius, is an osmotic diuretic presented as an intravenous solution for intravenous use. It is employed to reduce cerebral edema, manage increased intracranial pressure, treat acute renal failure, and lower intra‑ocular pressure in glaucoma.

GNH India supplies Mannitol Fresenius as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, transplant centres, oncology centres, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Fresenius Kabi Polska Sp. Z O.O.

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Indications & Clinical Uses

Mannitol acts as an osmotic agent to manage fluid‑related conditions in the brain, eye and kidneys.

  • Cerebral edema: reduces brain swelling by drawing fluid into the vascular compartment.
  • Increased intracranial pressure: lowers pressure within the skull, helping to prevent herniation.
  • Acute renal failure: promotes diuresis to assist renal clearance of waste products.
  • Glaucoma: decreases intra‑ocular pressure by increasing aqueous humor outflow.

How It Works

  • Mannitol creates an extracellular osmotic gradient that draws water from intracellular and interstitial spaces into the vascular compartment, raising plasma osmolarity. The resulting increase in intravascular volume promotes renal filtration and urine output, while also reducing fluid volume in the brain and eye, thereby lowering intracranial and intra‑ocular pressures.

Side Effects

Mannitol may cause a range of adverse reactions, from mild to severe.

Common Side Effects

  • Headache: mild to moderate discomfort.
  • Nausea or vomiting: gastrointestinal upset.
  • Thirst or dry mouth: increased fluid demand.
  • Electrolyte disturbances: mild hyponatremia or hypokalemia.

Serious or Rare Side Effects

  • Pulmonary edema: fluid accumulation in the lungs.
  • Severe allergic reaction: rash, itching, or anaphylaxis.
  • Renal tubular necrosis: impaired kidney function.
  • Cardiac arrhythmia: abnormal heart rhythm.

Precautions & Warnings

Before administering Mannitol, consider the following safety measures.

  • Monitor fluid balance: track input and output to avoid overload.
  • Check serum electrolytes: correct imbalances prior to infusion.
  • Adjust dose in renal impairment: reduced clearance may require lower amounts.
  • Use cautiously in heart failure: risk of fluid shifts and worsening symptoms.
  • Avoid rapid infusion rates: administer over the recommended time to limit hypotension.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Mannitol can interact with other medications, affecting safety and efficacy.

Major Interactions (Avoid)

  • Loop diuretics: additive diuretic effect may cause severe electrolyte loss.
  • Lithium: increased lithium levels and risk of toxicity.
  • Insulin or oral hypoglycemics: may enhance hypoglycemia.

Moderate Interactions (Monitor Closely)

  • ACE inhibitors or ARBs: may potentiate renal effects and affect blood pressure.
  • Antihypertensives: additive blood‑pressure‑lowering effect requires monitoring.

Frequently Asked Questions

Mannitol Fresenius is an intravenous osmotic diuretic used to reduce cerebral edema, lower increased intracranial pressure, manage acute renal failure by promoting diuresis, and decrease intra‑ocular pressure in glaucoma patients.

Mannitol works by creating an osmotic gradient that pulls water from tissues into the bloodstream, increasing plasma osmolarity. This draws fluid out of the brain and eye, reduces swelling, and enhances urine production, helping to clear excess fluid and waste.

The dosage of Mannitol Fresenius is determined by the prescribing clinician based on the specific indication, patient weight, renal function and clinical response. Dosing regimens are individualized and should follow the prescriber’s instructions.

The safety of Mannitol in pregnancy and lactation has not been definitively established. It should only be used if the potential benefit justifies any potential risk to the fetus or infant, and the decision should be made by the treating physician.

To order Mannitol Fresenius, submit an enquiry on the product page at gnhindia.com with the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and required import documentation.

Mannitol is a widely used osmotic diuretic with rapid onset and predictable renal clearance. Compared with alternatives such as hypertonic saline, Mannitol provides both diuretic and intracranial pressure‑lowering effects, but may require closer monitoring of electrolytes and fluid balance.

Mannitol Fresenius should be stored at 2‑8 °C, kept refrigerated, protected from light, and must not be frozen or shaken. Ensure the vial remains in its original packaging until use to maintain sterility.

Mannitol Fresenius is administered intravenously. The solution is typically infused over a controlled period, as directed by the prescriber, to achieve the desired osmotic effect while monitoring vital signs and fluid status.

Serious risks include pulmonary edema, severe electrolyte disturbances, renal tubular necrosis, cardiac arrhythmias, and anaphylactic reactions. Prompt recognition and management of these events are essential, and patients should be closely monitored during therapy.

Mannitol is contraindicated in patients with known hypersensitivity to mannitol, severe dehydration, active intracranial bleeding, uncontrolled heart failure, or severe renal impairment where fluid removal could be harmful.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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