Product image of Mannitol Viaflo Baxter (Mannitol) supplied by GNH India

Mannitol Viaflo Baxter

Active Ingredient:
Mannitol
Origin:
EU

Mannitol Viaflo Baxter (Mannitol)

Mannitol, the active ingredient in Mannitol Viaflo Baxter, is an osmotic diuretic presented as a sterile solution for injection for intravenous use. It reduces intracranial pressure, promotes diuresis in acute renal failure, and lowers intraocular pressure in patients requiring rapid fluid shifts.

GNH India supplies Mannitol Viaflo Baxter as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals, transplant centres, oncology centres, pharmacies and clinics worldwide. The company adheres to EU GMP standards and provides temperature‑controlled logistics for injectable products. Its global network ensures timely delivery to critical care settings.

Manufacturer / TM Owner

Baxter Medical Ab

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Indications & Clinical Uses

Mannitol acts as an osmotic diuretic and is employed in conditions where rapid fluid shifts are needed.

  • Intracranial hypertension: reduces intracranial pressure by drawing water out of brain tissue.
  • Acute renal failure: promotes diuresis to aid renal clearance of waste products.
  • Elevated intraocular pressure: lowers eye pressure in glaucoma or ocular surgery settings.

How It Works

  • Mannitol increases plasma osmolality, creating an osmotic gradient that pulls water from intracellular and interstitial compartments into the vascular space. This expansion of intravascular volume enhances renal filtration, facilitates diuresis, and reduces pressure in confined compartments such as the cranial and ocular spaces, thereby alleviating edema and pressure-related complications.

Side Effects

Mannitol may cause a range of adverse reactions, from mild to severe.

Common Side Effects

  • Headache: mild to moderate pain often transient.
  • Nausea or vomiting: gastrointestinal upset after infusion.
  • Electrolyte imbalance: hypokalemia or hypernatremia.
  • Transient hypotension: drop in blood pressure during rapid infusion.
  • Fluid overload: signs of edema in susceptible patients.

Serious or Rare Side Effects

  • Acute renal failure exacerbation: worsening kidney function.
  • Pulmonary edema: fluid accumulation in lungs.
  • Severe electrolyte disturbances: dangerous shifts in sodium or potassium.
  • Anaphylactoid reaction: rash, bronchospasm, or shock.
  • Hemolysis: destruction of red blood cells.
  • Severe hypotension: profound drop in blood pressure requiring intervention.

Precautions & Warnings

Mannitol should be used with careful clinical monitoring.

  • Monitor electrolytes: check serum sodium and potassium levels regularly.
  • Assess renal function: evaluate creatinine and urine output before and during therapy.
  • Caution in heart failure: avoid volume overload in patients with compromised cardiac function.
  • Avoid rapid infusion: administer over the recommended time to reduce hypotension risk.
  • Adjust for dehydration: correct fluid deficits before initiating therapy.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Mannitol can interact with several medications, requiring vigilance.

Major Interactions (Avoid)

  • Loop diuretics: may cause severe electrolyte imbalance.
  • ACE inhibitors: can enhance hypotensive effects.
  • Lithium: increased lithium serum concentrations.
  • Anticoagulants: heightened risk of bleeding due to volume shifts.

Moderate Interactions (Monitor Closely)

  • NSAIDs: may diminish diuretic efficacy.
  • Corticosteroids: can promote fluid retention.
  • Anticonvulsants: potential alteration of serum sodium affecting seizure control.

Frequently Asked Questions

Mannitol Viaflo Baxter is an intravenous osmotic diuretic used to lower intracranial pressure, promote diuresis in acute renal failure, and reduce intraocular pressure in patients who need rapid fluid redistribution.

Mannitol works by increasing the osmolality of plasma, which draws water from cells and interstitial spaces into the bloodstream. This osmotic shift expands intravascular volume, enhances kidney filtration, and reduces pressure in confined compartments such as the brain and eye.

The dosage of Mannitol Viaflo Baxter is determined by the prescribing clinician based on the specific indication, patient weight, renal function, and clinical response. Healthcare professionals calculate the appropriate infusion rate and total amount for each individual case.

Mannitol’s safety in pregnancy and lactation is not well established, and the pregnancy category is listed as unknown. It should only be used if the potential benefit justifies any potential risk to the fetus or infant, and decisions should be made by a qualified healthcare provider.

To order, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain if needed), and necessary import documentation.

Mannitol is a widely used osmotic diuretic that provides rapid plasma expansion and pressure reduction. Compared with hypertonic saline, Mannitol has a lower sodium load and is less likely to cause hypernatremia, while offering similar efficacy in decreasing intracranial and intraocular pressures.

Mannitol Viaflo Baxter should be stored at 2‑8 °C in a refrigerator, protected from light, and must not be frozen or shaken. Before use, inspect the solution for particulate matter or discoloration and allow it to reach room temperature if required for administration.

Mannitol Viaflo Baxter is administered intravenously by slow infusion through a sterile IV line. The infusion rate and total volume are set by the treating physician, who monitors the patient’s vital signs, urine output, and electrolyte status throughout the procedure.

Serious risks include acute renal failure worsening, pulmonary edema, severe electrolyte disturbances (especially hypernatremia or hypokalemia), anaphylactoid reactions, hemolysis, and profound hypotension. Prompt recognition and supportive management are essential if any of these events occur.

Mannitol is contraindicated in patients with known hypersensitivity to mannitol, severe dehydration, active intracranial bleeding, uncontrolled heart failure, or severe renal impairment where fluid removal could be harmful. Clinicians must evaluate each patient’s condition before initiating therapy.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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